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David A. Sinclair Profile picture
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26 Sep, 4 tweets, 2 min read
Resveratrol prevents calcification of arteries in rats & lowers zombie (senescent) cell markers via the longevity enzyme SIRT1👇Big effect #Wellbeing 1/4…
2/ Postmenopausal women are at risk of heart disease. These rats were made ‘post-menopausal’ by removing their ovaries. Reference:
tinyurl.com/9cxjr4x9
3/ Sections through the aorta. Thinner is more useful. N = control, normal rat; O = removed the ovaries to simulate menopause; E = estradiol replacement therapy; R = resveratrol
4/ Model:

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More from @davidasinclair

David A. Sinclair Profile picture
22 Sep
Aging news: Abundance of a chemical called a DNA-methyl represents biological age🧬Using this clock, a 2-year study reports that switching to a low-sugar, Mediterranean-style diet with exclusive use of olive oil, slows aging 💪Details in thread tinyurl.com/4atd54s5
2/ The intervention diet included: (a) replacement of refined grains with whole grains; (b) at least one portion of raw vegetables & one of cooked vegetables each meal; (c) fish at least 2–3 times weekly...
3/ (d) reduction of fresh and processed red meat to less than once weekly; (e) consumption of >3–4 portions of legumes / pulses per week; (f) daily consumption of >2–3 portions fruit; (g) cakes & desserts consumed no more than once a week...
Read 5 tweets
David A. Sinclair Profile picture
19 Sep
In human clinical studies, pure Resveratrol 🍷 improves blood sugar levels, good cholesterol, blood pressure, kidney filtration & fatty liver, as we showed in mice. I’m gonna keep mixing it with yogurt/olive oil. Refs👇 lifespanbook.com, p.304
Resveratrol is a grey powder, not brown and it’s fat- not water-soluble. If it’s brown and you take it with water, not ideal
Resveratrol’s benefits 🍷 in humans:
Liver:
tinyurl.com/4xr9nnw6
CVD cancer, diabetes and AD
tinyurl.com/fs8h9w2p
Kidney
tinyurl.com/hsnujv9x
Blood pressure and vessel dilation
tinyurl.com/zz652kr3
Blood glucose, HDL and triglycerides
tinyurl.com/2y9ym4wk
Read 4 tweets
David A. Sinclair Profile picture
16 Aug
20 year study of 13,466 people finds meat-inclusive ‘western’ diet is associated with more chronic diseases & cancer, compared to a vegetable & fruit-based diet 🥩🌱 link.springer.com/article/10.100…
“Westernized diets are known to be deficient in Mg, zinc, folate, and vitamins C, E, & K. Deficiencies in the micronutrients above [are] related to metabolic syndrome, CVD, and coronary heart disease, which are principal causes of mortality in the U.S.”
Dietary patterns were categorized into ‘prudent’ (fruits and vegetables), ‘western’ (red meat, sweets, pastries, oils), ‘traditional’ (red meat, legumes, potatoes, bread), and ‘fish and alcohol’
Read 4 tweets
David A. Sinclair Profile picture
12 Aug
Syringaresinol from Japanese Plums, like Resveratrol, activates the longevity enzyme SIRT1. New study confirms its benefits are due to a mimicry of fasting 🥗 tinyurl.com/3vnh36wz
Thanks @agingdoc1 for the heads up
This molecule is interesting. It prevents cellular senescence (formation of zombie cells 🧟‍♀️), boosts antioxidant defenses, suppresses enzymes that promote skin aging, and in 🐁 with excess oxidative damage, reverses skin aging 8 weeks #beauty tinyurl.com/rwh4rf2z
Read 4 tweets
David A. Sinclair Profile picture
15 May 20
One third of homes have a cat. There are 600M globally. A study @NEJM confirms cats spread #coronavirus to each other & may spread it between family members. I’m concerned it could mix with a fatal cat coronavirus... 1/n
Some say “Well, the virus has not been proven to spread from cat to human.” As @StevenAustad has pointed out, this hasn’t been tested or disproven either. It is like saying in December 2019 that a virus in China hasn’t been proven to spread to the US. 2/n
Is no one but me concerned about viral genetic mixing & a new strain emerging from cats? Cats have their own #coronaviruses. They can cause one of the most fatal cat diseases known by destroying white blood cells (HIV-like). 3/n
Read 10 tweets
David A. Sinclair Profile picture
14 May 20
1/ Let me start by saying that this was a fantastic piece on vaccine development by @stuartathompson at @NYTimes.
2/ Having started a now public company that makes vaccines (thanks to my cofounder Darren Higgins and to @gatesfoundation), I can tell you many people don't appreciate just how long it takes to develop a drug.
3/ Vaccines often take longer. Of every drug that is picked to go into humans, less than 5% will ultimately be approved. Luckily, the outbreaks of SARS and MERS in 2004 and 2012 have given us a head start (SARS and SARS-CoV-2 are ~80 percent identical).
Read 7 tweets

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