1/ HOW COVID TRANSMISSION WORKS: the short version

I believe it is extremely important to communicate clearly how transmission really happens.

Then, one can understand easily real ways to limit transmission. And it reduces resistance to e.g. masks.
2/ SOME, NOT ALL infected people (those with high viral load during a certain period of the illness) exhale aerosols that float in the air. Many more if they talk / yell / sing / exercise.

More details in this paper in @ScienceMagazine:

3/ Those aerosols float like cigarette smoke, which is another aerosol

4/ It is very easy to get infected in close proximity, because we inhale a lot of the air that leaves the other person with little dilution

journalofhospitalinfection.com/article/S0195-…
5/ The dominance of short-range airborne infection in close proximity has been confused for 110 years with "sprayborne droplet transmission", since Charles Chapin made that error in his 1910 book, that became the #DropletDogma until now

papers.ssrn.com/sol3/papers.cf…
6/ The error confusing short-range airborne infection in close proximity with sprayborne droplet infection was foundational in the @CDCgov, and from there it has permeated the infection control book everywhere, as we discuss in our preprint:

papers.ssrn.com/sol3/papers.cf…
7/ One can get infected, not only in close proximity, but also when sharing room air, bc "exhaled smoke" accumulates in room

E.g. the Skagit choir we investigated, & 1000s of others. All superspreading investigated points to airborne, none to droplets

8/ @WHO and others tell us that airborne transmission is only an issue "when there is poor ventilation"

But if exhaled infectious aerosols can infect when they accumulate in a room, they MUST be much more infectious in close proximity. (What has traditionally called "droplets")
9/ CRITICALLY, ventilation is "not good" IN MOST INDOOR SPACES WORLDWIDE, including in advanced countries like US. Shouldn't be made to sound like an exception, but we should assume that ventilation is not good unless demonstrated otherwise (CO2 meters)

science.org/doi/10.1126/sc…
10/ If you want more details on how we know airborne transmission is dominant for COVID-19, see this @TheLancet paper, explained in this thread:

11/ If you want more details on how all (or almost all) respiratory diseases are actually airborne, see this @ScienceMagazine paper, explained in this thread:

(Not that surprising if you think about it! They are respiratory diseases after all)

12/ If you want more details on how to protect yourself from airborne transmission, see Tweets #40-80 and later on the thread explaining the @ScienceMagazine paper:

13/ If you want to understand the history of how the #DropletDogma became SOOO entrenched, so that @WHO and @CDCgov were unable to understand transmission, see this thread on the history:

14/ For more details on the history, see the Randall et al. paper that we recently published in J. Royal Society Interface:

15/ For even more details on the history (an article that explains similar material to the thread linked in tweet #13 here), see his preprint (under peer-review right now):

papers.ssrn.com/sol3/papers.cf…
16/ Although perhaps best way to understand history is to read this article in @wired by @meganmolteni

Explains the research led by @katierandall and @linseymarr (with yours truly supporting as I could) to find the origins of the errors in #DropletDogma

wired.com/story/the-teen…
17/ If you want more details about the implications of this paradigm shift in the understanding of respiratory disease transmission for indoor air quality and ventilation, see this @ScienceMagazine paper, explained in this thread:

18/ For a comic version explaining respiratory disease transmission and how to protect ourselves, see this thread, which explains the comics that @ChiaWang8 (lead author of @ScienceMagazine paper) made:

19/ For a summary of the huge error made by @WHO declaring "FACT: IT IS NOT AIRBORNE" and calling airborne "misinformation"(one of the worst errors in the history of public health) see this thread on the 1-year anniversary:

20/ Only hope that my colleagues and I can stop having to shout from the Twitter rooftops, because finally @WHO and @CDCgov etc. will say this themselves. Science is extremely clear.

But there are residual confusion w/ #DropletDogma, political obstacles

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More from @jljcolorado

29 Oct
1/ Algún no-científico repite que los aerosoles no pueden ser importantes para el contagio de COVID-19 porque si lo fueran "las tasas de ataque secundario domiciliario (TAS/SAR) oscilarían entre el 80 y el 100%"

Y confunde al personal, así que explico porque esto es erróneo.
2/ La tuberculosis pulmonar (TBP) y el sarampión las acepta todo el mundo como de transmisión aérea. La TBP SÓLO se transmite por el aire.

Sin embargo NO se infectan todos los que comparten el aire con un tuberculoso.
3/ Por ejemplo en este estudio sólo se infectó el 40% de los trabajadores que compartían el aire en la misma oficina tras una exposición de 4 semanas

(La TBP sin tratar puede ser infecciosa más de un año, y eso le ayuda a sobrevivir como enfermedad)

pubmed.ncbi.nlm.nih.gov/1907115/
Read 29 tweets
13 Oct
1/ Our article on historical droplet error (#DropletDogma) just published after peer-review

"How did we get here: what are droplets and aerosols and how far do they go? A historical perspective on the transmission of respiratory infectious diseases"

doi.org/10.1098/rsfs.2…
2/ An honor to have worked in an interdisciplinary team led by @linseymarr and Lydia Bourouiba of @MIT, together with the amazing @katierandall and @EThomasEwing

TL;DR: understanding of "droplets" in medicine is based on large errors that went mostly unnoticed until now
3/ We have written a review article on the wider arc of history, which is now under peer-review, preprint here:

papers.ssrn.com/sol3/papers.cf…

Already ranked #1 on their Infectious Diseases e-journal: papers.ssrn.com/sol3/topten/to…
Read 36 tweets
23 Sep
1/ TRANMISIÓN DE VIRUS RESPIRATORIOS POR EL AIRE: DIVULGACIÓN CON COMICS

Nuestro artículo reciente en @ScienceMagazine, presentado de forma comprensible a través de comics.

Artículo: science.org/doi/10.1126/sc…

Comics creados por @ChiaWang8, y traducidos al español por @nanoprofe
2/ El elenco de actores: las gotículas (grandes, caen rápidamente al suelo) y los aerosoles (pequeños, flotan en al aire como el humo)
3/ ¿Qué son los aerosoles?
Read 20 tweets
21 Sep
1/ Where Are the Tests?

"Other countries are awash in Covid tests. The U.S. is not."

By @DLeonhardt in @nytimes

nytimes.com/2021/09/21/bri…
2/ Thanks to the @nytimes for bringing the focus onto this US problem, that @michaelmina_lab has been advocating for solving since the start of the pandemic.
3/ "Rapid testing — i.e. antigen testing — allows pplto learn within minutes whether they are carrying enough Covid-19 virus to be contagious.

With this knowledge, infectious people can stay home and quarantine before they infect others. Everybody else can carry on w/ life"
Read 11 tweets
15 Sep
1/ Prof. Lidia Morawska, the leader of our "Group of 36 Scientists" that challenged @WHO from April 2020 on airborne transmission of SARS-COV-2, has been selected as one of the 100 Most Influential People of 2021 by @TIME

time.com/collection/100…
2/ "Lidia Morawska stands out among peers for her work in recognizing the importance of aerosol transmission and marshaling the data that would convince the World Health Organization and other authoritative bodies to do the same."
3/ This is a paper from our group and colleagues that Lidia led, and that was published in @ScienceMagazine earlier this year:

"A paradigm shift to combat indoor respiratory infection"

This paradigm shift has major implications for global health

science.org/doi/full/10.11…
Read 10 tweets
9 Sep
1/ AIRBORNE TRANSMISSION OF RESPIRATORY VIRUSES: THE COMIC VERSION

Supplementary multimedia prepared by lead author @ChiaWang8 to our recent @ScienceMagazine peer-reviewed paper

science.org/doi/10.1126/sc…

@kprather88 @linseymarr @zeynep @Lakdawala_Lab @zeynep
2/ The cast of characters: aerosols & droplets
3/ So what are aerosols?
Read 23 tweets

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