Point to me on this chart where the pain and suffering of shareholders is.
Two years of money raining on them crying over 2 days of the gravy train stopping at a station to refill.
"But muh stock market missed out on two days of 🔼. The SEC should arrest Bancel for his words."
"Implying none of the vaccines will work against the VIRUS" - whaat? Where did he imply that?
He said "this is not going to be good." How is this controversial? Should he have said "the more spike + RBD AA substitutions the better. Bring 'em on." ???
How is this "speculation"?? Antigenic drift is now "speculation"?
Basic immunology is speculation?
Speculation in what sense?
Some epitopes are gone. Some mAbs won't bind or neutralize. What part of this is controversial?
Let's not reinvent immunology for COVID-19 please.
If you are taking three shots of one of the most immunogenic vaccines in the history of vaccinology just to regain high protection against this variant, then that is an admission that there is loss of efficacy of 1 or 2 shot vaccines against this variant.
This is a biphasic disease - a viral phase & an immunopathological one.
There may be 𝑠𝑜𝑚𝑒 virus in the 2nd phase & there is 𝑠𝑜𝑚𝑒 immunopathology in the 1st, & there can be rapid deterioration/cascading of 1st into 2nd, but many only experience one phase.
Biphasic.
The ancestral strain of SARS-CoV-2 had a relatively mild viral phase and a possibly terrible 2nd phase. People felt mild flu-like symptoms in before rapidly deteriorating.
Subsequent variants have resulted in increased virulence, with the 1st phase being more severe, esp. Delta.
Animal challenge trials, even in macaques, show only the first phase. Even unvaccinated animals only experience 7 days of a typical respiratory illness and that's it.
In the 1968 flu pandemic, the first batch of vaccines came out on day 66, and 5 million doses were released by day 87.
But please tell me that the mRNA vaccines are the fastest thing possible & that we should build all our future pandemic plans on the "tweeked in 2 days" mRNA.
A lot of doses were produced...
But even though it was really fast, the vaccines didn't come soon enough.
We didn't learn this lesson in 1968.
We repeated the mistakes for H1N1 and now once more for COVID variants.
The only reason we update vaccines is because of a new strain.
We don't wait for data on the severity of influenza B Yamagata or the transmissibility of this year's H3N2 to make an update, nor do we take 2+ shots of last year's flu vaccine to make up for strain mismatch.
We didn't wait for hospitalization & intubation data for the recent H3N2 outbreak in the news.
We just update the vaccine quietly.
We don't dismiss any influenzas as "friendly" or "too nice to attack with a vaccine." We target the top 4 indiscriminately, regardless of severity.
The fragility, limited shelf-life and wastage of Moderna and Pfizer vaccines is a feature, not a bug.
$MRNA $PFE
The West's (one sided) loyalty to the mRNA vaccines, despite a non-negligible resistance to the platform from some patients & parents, some rising contraindications & undeniably increasing prices, loyalty to the point of cancelling orders from other companies, is almost comical.
Countries basically create a vaccine duopoly themselves, with their own research ( $MRNA) or gov funding (OWS), then with their own orders, then making it the only recognized vaccine for foreigners' vax-pass, then complain of duopoly tactics & higher prices. #SelfInflicted