The only reason we update vaccines is because of a new strain.
We don't wait for data on the severity of influenza B Yamagata or the transmissibility of this year's H3N2 to make an update, nor do we take 2+ shots of last year's flu vaccine to make up for strain mismatch.
We didn't wait for hospitalization & intubation data for the recent H3N2 outbreak in the news.
We just update the vaccine quietly.
We don't dismiss any influenzas as "friendly" or "too nice to attack with a vaccine." We target the top 4 indiscriminately, regardless of severity.
I'm sorry you believed in Wuhan-Hu-1 or USA-WA1/2020 being the "one ring to rule them all" but whoever told you that lied to you.
We don't just vaccinate against the HPV serotypes that cause cancer, just as we don't just vaccinate against the influenza strains that cause severe disease in the young.
The fact that we were not prepared for antigenic drift, neither psychologically nor logistically, despite getting hint after hint that a change will one day be needed (Alpha, Beta, Gamma, Delta) says more about us than about Omicron.
We had one year of WT in a naive world population & we saw a whole range of disease, from non-seroconverting asymptomatic all the way to death.
You want to debate Omicron's severity in multiple demographics with 0-3x vaccine + 0-3x infections baseline immunity, be my guest.
Comparing transmissibility of this vs Delta? This, in winter, during a month of holidays, family gatherings, travel, vacations, the lowest mask compliance since the start of the pandemic?
Is this not an apples to mulberries comparison?
This is a solved (scientific) problem. We just need to roll out the doses, roll up the sleeves and our B cells to roll out the globulins.
Strain update for the vaccines, phase out the dated mAbs, and bring new ones for the vulnerable.
Not trying to be condescending or tell people to "calm down" like a blue checkmark having a panic attack in private, but this is just a manufacturing issue now.
I won't "tout" T cells to you, but will say that many of our antibodies still work. But we still want better.
It's fine to be concerned and to take precautions (as one normally would), but don't panic. God forbid we have another Black Tuesday market crash like the one we had yesterday, because THAT would be truly scary.
This is a biphasic disease - a viral phase & an immunopathological one.
There may be 𝑠𝑜𝑚𝑒 virus in the 2nd phase & there is 𝑠𝑜𝑚𝑒 immunopathology in the 1st, & there can be rapid deterioration/cascading of 1st into 2nd, but many only experience one phase.
Biphasic.
The ancestral strain of SARS-CoV-2 had a relatively mild viral phase and a possibly terrible 2nd phase. People felt mild flu-like symptoms in before rapidly deteriorating.
Subsequent variants have resulted in increased virulence, with the 1st phase being more severe, esp. Delta.
Animal challenge trials, even in macaques, show only the first phase. Even unvaccinated animals only experience 7 days of a typical respiratory illness and that's it.
In the 1968 flu pandemic, the first batch of vaccines came out on day 66, and 5 million doses were released by day 87.
But please tell me that the mRNA vaccines are the fastest thing possible & that we should build all our future pandemic plans on the "tweeked in 2 days" mRNA.
A lot of doses were produced...
But even though it was really fast, the vaccines didn't come soon enough.
We didn't learn this lesson in 1968.
We repeated the mistakes for H1N1 and now once more for COVID variants.
The fragility, limited shelf-life and wastage of Moderna and Pfizer vaccines is a feature, not a bug.
$MRNA $PFE
The West's (one sided) loyalty to the mRNA vaccines, despite a non-negligible resistance to the platform from some patients & parents, some rising contraindications & undeniably increasing prices, loyalty to the point of cancelling orders from other companies, is almost comical.
Countries basically create a vaccine duopoly themselves, with their own research ( $MRNA) or gov funding (OWS), then with their own orders, then making it the only recognized vaccine for foreigners' vax-pass, then complain of duopoly tactics & higher prices. #SelfInflicted