This is a biphasic disease - a viral phase & an immunopathological one.

There may be 𝑠𝑜𝑚𝑒 virus in the 2nd phase & there is 𝑠𝑜𝑚𝑒 immunopathology in the 1st, & there can be rapid deterioration/cascading of 1st into 2nd, but many only experience one phase.

Biphasic.
The ancestral strain of SARS-CoV-2 had a relatively mild viral phase and a possibly terrible 2nd phase. People felt mild flu-like symptoms in before rapidly deteriorating.

Subsequent variants have resulted in increased virulence, with the 1st phase being more severe, esp. Delta.
Animal challenge trials, even in macaques, show only the first phase. Even unvaccinated animals only experience 7 days of a typical respiratory illness and that's it.

COVID-19 in humans is different.
The only animal challenge trial that shows something close to what we experience is the accidental, overlooked finding buried in the supplement.

While looking for mechanisms of Long COVID, the authors saw what resembles the 2nd phase of COVID in humans.

biorxiv.org/content/10.110…

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More from @NickytaLeb

3 Dec
In the 1968 flu pandemic, the first batch of vaccines came out on day 66, and 5 million doses were released by day 87.

But please tell me that the mRNA vaccines are the fastest thing possible & that we should build all our future pandemic plans on the "tweeked in 2 days" mRNA.
A lot of doses were produced...
But even though it was really fast, the vaccines didn't come soon enough.

We didn't learn this lesson in 1968.
We repeated the mistakes for H1N1 and now once more for COVID variants.
Read 8 tweets
1 Dec
The questions of transmissibility, severity, symptomology, etc. are academic and for the most part irrelevant.

This is a simple question of vaccine strain update. We do this all the time.

Boosting helps in short term, new shot next. New mAbs now.
The only reason we update vaccines is because of a new strain.

We don't wait for data on the severity of influenza B Yamagata or the transmissibility of this year's H3N2 to make an update, nor do we take 2+ shots of last year's flu vaccine to make up for strain mismatch.
We didn't wait for hospitalization & intubation data for the recent H3N2 outbreak in the news.
We just update the vaccine quietly.

We don't dismiss any influenzas as "friendly" or "too nice to attack with a vaccine." We target the top 4 indiscriminately, regardless of severity. Image
Read 11 tweets
1 Dec
"Unhelpful" to whom? Whom is he supposed to help? He was asked a question, he gave his answer. Was the media shopping for good news?

"Stock markets fell on the news" - Who gives a shit? How is this important? Image
Point to me on this chart where the pain and suffering of shareholders is.

Two years of money raining on them crying over 2 days of the gravy train stopping at a station to refill. Image
"But muh stock market missed out on two days of 🔼. The SEC should arrest Bancel for his words." Image
Read 7 tweets
29 Nov
Good news for everyone this morning - COVID is over.

You literally never have to think about COVID ever again.
More good news: Scientists on Twitter are saying that the vaccines are 99.9% effective and will remain effective for life.
If you are vaccinated and everyone around you will not spread any COVID to anyone. Period.
Read 9 tweets
14 Nov
The morons are at it again.

"What makes more sense"?

There are only two options. 3rd dose or no 3rd dose.

In what reality does not taking a vaccine make more sense than taking one?

None. Makes no immunological sense.
What difference does it make?
"Exhaust your immune system" has entered the chat.
Read 8 tweets
13 Nov
The fragility, limited shelf-life and wastage of Moderna and Pfizer vaccines is a feature, not a bug.

$MRNA $PFE
The West's (one sided) loyalty to the mRNA vaccines, despite a non-negligible resistance to the platform from some patients & parents, some rising contraindications & undeniably increasing prices, loyalty to the point of cancelling orders from other companies, is almost comical.
Countries basically create a vaccine duopoly themselves, with their own research ( $MRNA) or gov funding (OWS), then with their own orders, then making it the only recognized vaccine for foreigners' vax-pass, then complain of duopoly tactics & higher prices.
#SelfInflicted
Read 8 tweets

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