This is a biphasic disease - a viral phase & an immunopathological one.
There may be 𝑠𝑜𝑚𝑒 virus in the 2nd phase & there is 𝑠𝑜𝑚𝑒 immunopathology in the 1st, & there can be rapid deterioration/cascading of 1st into 2nd, but many only experience one phase.
Biphasic.
There may be 𝑠𝑜𝑚𝑒 virus in the 2nd phase & there is 𝑠𝑜𝑚𝑒 immunopathology in the 1st, & there can be rapid deterioration/cascading of 1st into 2nd, but many only experience one phase.
Biphasic.
The ancestral strain of SARS-CoV-2 had a relatively mild viral phase and a possibly terrible 2nd phase. People felt mild flu-like symptoms in before rapidly deteriorating.
Subsequent variants have resulted in increased virulence, with the 1st phase being more severe, esp. Delta.
Subsequent variants have resulted in increased virulence, with the 1st phase being more severe, esp. Delta.
Animal challenge trials, even in macaques, show only the first phase. Even unvaccinated animals only experience 7 days of a typical respiratory illness and that's it.
COVID-19 in humans is different.
COVID-19 in humans is different.
The only animal challenge trial that shows something close to what we experience is the accidental, overlooked finding buried in the supplement.
While looking for mechanisms of Long COVID, the authors saw what resembles the 2nd phase of COVID in humans.
biorxiv.org/content/10.110…
While looking for mechanisms of Long COVID, the authors saw what resembles the 2nd phase of COVID in humans.
biorxiv.org/content/10.110…
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