Looking at $RXRX.

This is a company I recently got into. I really think what they are doing is very cool. I have been taking my time and going through everything I could about them. Now I am here to share it all with you.
1/ This company is all about using robots to do millions of experiments and record the data. They feed all that data into a super computer and turn it into a platform that can develop drugs.
2/ The statistics show that it takes well over $1 billion per drug for development and 90% of those drugs fail to ever reach commercial. That cost of drug development is way too high. Using AI and machine learning, they can reduce those costs and increase the success.
3/ This is the kind of platform that can yield a huge output of development candidates that can be developed wholly or with partners. They have a ton of potential for collaborations. They have 1 so far with Bayer.
4/ They have 4 assets going into phase 2 in 2022 and multiple other program in early discovery. For a company with 4 phase 2 assets, they seem fairly cheap at around $3 billion market cap. There are phase 1 companies trading at 2x that price.
5/ Their first drug is a MEK inhibitor. The first thing I thought was "Oh God, not another MEK inhibitor". This does work differently as its designed to stay in the intestine where its needed for APC instead of being absorbed into the body.
6/ I went over their phase 1 safety data, and I did find it a bit concerning. I will wait to see the phase 2 data.
7/ Their second drug is a HDAC inhibitor. This is another one that might seem to be very competitive at this point, but again, this one has CNS penetration to target Neurofibromitosis. I went through the phase 1 safety data and it looked good so far.
8/ Their second asset targets GSK3Beta which I think is another part of the Insulin pathway if I recall correctly. The early safety data looked good.
9/ The last drug they have in the clinic is for CCM. Its a superoxide scavenger molecule. The safety data that I saw looked good.
10/ The last part about the company that I still haven't really gotten to know that well is the management. That part will take time. Overall, I think its a fantastic company, with really cool science and at a very reasonable valuation.

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More from @Biotech2k1

30 Nov
Looking at $SDGR:

This company was one I use to bash a lot for its valuation when it was up over $70. Now, I am recommending it. It has strong fundamentals and a cheap valuation. Let us take a look.
1/ This company is made of of 2 parts. The first is the software business which they developed. Its about physics based chemistry to predict how proteins will move and targeting them with therapies.
2/ They license their software to over 1,500 global companies and have over 25 partnerships for the use of their software in drug development.
Read 14 tweets
27 Nov
Looking at $SANA:

This company gets no recognition as its not owned by some of the funds that lead to cult like status for some companies. They are probably one of the most disruptive companies in biotech.
1/ I think $SANA could be taking on all the things the CRISPR companies are doing ex-vivo and doing it in-vivo. They are combining 3 of the most powerful technologies in the market today with Fusogen, CRISPR and iPSC.
2/ The fact that this company is only at $3 billion market cap when they are at $5 to $10 billion is a gift for the retail investors. They could be bigger then all the CRISPR companies combined.
Read 18 tweets
27 Nov
Parking some pictures for my $SANA thread later.
Fusogen Image
Hypoimmune Image
Read 6 tweets
26 Nov
Don't ever ignore what the market is telling you.

This is a concept I have seen investors ignore for my 25 years in the market. The market isn't always right, but usually it is. I learned that over the many years. I never discount what the market is trying to tell me.
1/ I made a lot of money over the years picking a few great companies long before anyone else ever knew who they were. That doesn't mean the market was wrong. Many times I see people load up on all these "cheap" companies.
2/ Those companies that are trading at $800 million or so when the rest of their peers are $3 to $10 billion. These companies aren't this cheap because the entirety of millions of investors around the world are clueless.
Read 10 tweets
21 Nov
Looking at my Genomics Companies:

This has probably been the most bubbly space in biotech the past year. I dumped all these companies back in late January and only recently started buying any of them back.
I love the genomics space, but the cart is way ahead of the horse at this point. I think many of them are now down 50% or more from their highs as human behavior always goes from bubble to bust and back again. I still don't think any of these scream cheap yet.
I have:

$BEAM 2.02%
$CRSP .69%
$PACB 1.38%
$NVTA 1.38%

This theme makes up 5.47% of my portfolio.
Read 9 tweets
20 Nov
Looking at my Synthetic Biology Companies:

The synthetic biology space is all about creating new biology. This is mostly around engineering yeast or bacteria to become tiny factories. This offers a sustainable resource for rare products.
I have:

$DNA 1.38%
$TWST 1.38%
$ARMS 2.06%
$CDXS .69%

This theme makes up 5.51% of my portfolio.
$DNA is the fan favorite for this space, but it also prices in a huge amount of success already. They focus on engineering microbes to be tiny factories to product products. They also engineer microbes for commercial products like probiotics.
Read 9 tweets

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