Thread by @pj_saez

Did you know that some proteins can increase or *decrease* #CellMigration, depending on the cell type?

Check our review on how ion channels (#Pannexins) & #calciumsignaling regulate immune, non-immune & #cancer migration.

Hot from the press: readcube.com/articles/10.33… #SciComm
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It all started when we wrote something with @palomi_rock
The intro was so good & had so much new data that we decided to make a 'short' review/update of pannexins in #immunecells, focus on cell migration.
But things got out of hand & we started to include more cell types 😅🤷🏽‍♂️
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Then, @LpzLpz_Tami joined to help with migration of immune cells, such as #DendriticCells, #Tcells, #Neutrophils, and to do the beautiful figures @BioRender 😍
Next, @APalacio_s joined to bring a broader vision of migration's impact during neuroinflammation, senescence, etc
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About to publish we noticed that there was were many interesting data on #cancer cells so we added a new section for them, & also discuss about #cellcomm.
Interestingly, #Pannexin expression can either increase or decrease the migration of these cells.
The question was why?
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There is no definitive answer but it's definitely worthy to study how #cytoskeleton & #CalciumSignaling are differentially regulated by these ion channels.
Moreover, the #mechanosignaling of these proteins has not yet been studied in depth but some data is starting to pop up.
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Finally, I want to thank @palomi_rock & @LpzLpz_Tami (& @APalacio_s) for doing those tables that contain all the info for Panxs & migration
To the guest editors that invited us @EmmanuelDonnad1 @heleneDmoreau @renkawitzteam
& to the reviewers @dr_swayne & Eliseo Cheo Eugenin
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