This study evaluated the association between nutrient patterns with body fat and regional adiposity in middle-aged black South African men and women.
- "the plant-driven nutrient pattern is the most commonly consumed in South Africa. It is characterised by high factor loadings of magnesium, phosphorus, plant protein, carbohydrates, iron, B-vitamins and fibre...
"...Although the plant driven nutrient pattern was not significantly associated with total or regional fatness in the combined sample of men and women, we show for the first time that this nutrient pattern was associated with higher abdominal SAT in women but not men."
- "The animal protein and fat-driven nutrient pattern, characterised by animal protein, saturated fat, monounsaturated fat, polyunsaturated fat, and cholesterol, was associated with total and central adiposity...
"...This was the second most consumed nutrient pattern and suggested a shift towards a Westernised diet characterised by increased consumption of energy-dense foods, meat, butter, eggs and oils, which have been associated with obesity...
"...Notably, we also showed sexual dimorphism in the relationship between animal protein and fat driven nutrient pattern and BMI, showing a stronger relationship in men than women."
- "The 'vitamin C, sugar and potassium' driven nutrient pattern, which explained 11.7% of the variance in nutrient intake in our sample, suggests a diet high in the consumption of sugar sugar-sweetened beverages, such as carbonated soft drinks fruit juices and tea with milk...
"...we showed that this nutrient pattern was associated with higher total body fatness in the combined sample and higher abdominal SAT in women"
- "The retinol and vitamin B12 driven nutrient pattern, suggestive of fish- and animal-based food sources were associated with greater centralisation of body fat (android % FM and VAT) only."
Sex Differences in the Associations of Nutrient Patterns with Total and Regional Adiposity: A Study of Middle-Aged Black South African Men and Women (open access)
This one suggests that the antithrombotic effect of weight loss is preserved in the postprandial state, irrespective of the weight loss intervention.
- "This is the first study exploring postprandial changes in FVII activation and thrombin formation as a potential harmful mechanism in individuals with obesity during weight loss."
- "The present study demonstrates a postprandial increase in FVIIa after high-fat meals during diet-induced weight loss and surgery-induced weight loss...
Here's one more that shows that HOMA-IR is associated with albuminuria and renal function impairment, this time in individuals living in Southeast China.
"Our study has three main findings...
"...First, an increase in the prevalence of albuminuria and renal function impairment was associated with an increase in the HOMA-IR quartile in all men and women age >45 years...
This one found higher leisure-time physical activity levels to be associated with a lower risk of cardiovascular disease in Chinese retired adults, with the benefit threshold for CVD prevention equivalent to 3 to 5 times the world health organization (WHO) recommended minimum.
- The WHO recommends every adult to maintain a minimum of 150 min of moderate-intensity or 75 min of vigorous-intensity activity per week, which is equivalent to 7.5 weekly metabolic equivalent of task-hours ([MET]-hours/week) of physical activity.
- Compared with participants reporting LTPA less than the recommended minimum of 7.5 MET-hours/week, a lower risk was seen for those with 3 to 5 times the recommended minimum (22.5–37.5 MET-hours/week) with no additional benefit when exceeding 5 times the recommended minimum.
This one found that prolonged physiological and supraphysiological hyperinsulinemia can induce blunted acute insulin signaling, reduced insulin-stimulated glucose uptake, transcriptomic changes, and affect genes in insulin signaling pathways.
- "We demonstrated that prolonged physiological and supraphysiological hyperinsulinemia induced a reduction of AKT and ERK signaling and insulin-stimulated glucose uptake..."
- "Remarkably, while serum starvation partially reversed the effects of overnight hyperinsulinemia, much of the impaired acute insulin signaling and transcriptomic remodeling was sustained after 6 h of insulin withdrawal and serum starvation...
This one suggests that performing around 1800 MET-min/week (i.e. 64 min/day of moderate PA) is an effective method to prevent some major degenerative diseases that affect quality of life in a large part of the population over 50 years.
"American adults who perform at least 150 MET-min/week of PA presented reduced odds for sarcopenia, those who perform 150–1800 MET-min/week had reduced odds for osteoarthritis, and those who perform more than 1800 MET-min/week had reduced odds for osteoporosis...
"...It seems to be indicating that performing around 1800 MET-min/week (i.e. 64 min/day of moderate PA) is an effective method to prevent some diseases that affect quality of life in a large part of the population over 50 years."
This one suggests that low-grade systemic inflammation promotes proteasome activity through activation of the NF-κB signaling and reduces the insulin-dependent anabolic potential in the aged human skeletal muscle.
Main findings:
Older adults with plasma hsCRP > 1 mg/L (defined as elevated systemic inflammation; ESI), but otherwise healthy demonstrate:
i) increased proteasome activity, accompanied by increased protein carbonylation and IKKα/β phosphorylation.