Who created the PAXLOVID miracle #COVID19 drug? Pfizer makes you think they did alone. But it was created only with the critical help of advanced photon machines from taxpayer-funded US Dept of @Energy’s @argonne Lab. ➡️Make sure you remember that next time paying sky high drug $
2) Seriously— don’t give Pfizer all the glory for this Paxlovid drug. It was funded by you the taxpayer that made it all possible. Never let big pharma take advantage and claim they built it all. anl.gov/article/advanc…
3) “Work to determine the structure of the antiviral candidate was done at the (IMCA-CAT) beamline at the APS, operated by the Hauptman-Woodward Medical Research Institute (HWI) on behalf of a collaboration of pharmaceutical companies, of which Pfizer is a member.”
4) “As a member of IMCA-CAT, Pfizer routinely conducts drug development experiments at the APS, and the process of narrowing down and zeroing in on this drug candidate was performed over many months.
5) “IMCA-CAT, she said, delivers quality results in a timely manner, much faster than the home laboratories of the companies themselves can do.
Access like this to a DOE facility such as the APS, she said, is vitally important for a breakthrough like Paxlovid to happen.
6) ““This is an important illustration of how valuable the national laboratories are to advancing the work of U.S. industries, and that has a hugely beneficial impact on society. When the results have a global impact, as in the case of COVID-19, they motivate us and inspire us.”
7) “IMCA-CAT uses the X-rays to probe the atomic structures of proteins, like those that make up SARS-CoV-2. Scientists use this information to see how potential drug compounds may interact with virus. This lays the groundwork for the creation of new treatments, such as Paxlovid.
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JAMES WEBB!—the $10 billion James Webb Space Telescope has finally launched—100x more powerful than Hubble—is finally enroute to Lagrange Pointe 2 at ~1.5 million km from 🌍 & operate at -230 C. The #JamesWebb will change our understanding of the universe!
2) the James Webb is honestly one of the greatest crowning achievements of humanity. Seriously. It’s heat shield 🛡 helps achieve some the lowest temperatures ever—cooling it to much colder than deep space itself! bbc.co.uk/news/science-e…
3) the James Webb’s sun shield 🛡 is so badass that it can block all of the sun’s energy from reaching the telescope side except for 1 watt! You kid’s nightlight is 4 watts! And this sucker is in direct sunlight in LG2 of Earth!
Not “vague”—➡️We are staring at a thermonuclear-level bad pandemic 2.0 HMOG wave with #Omicron heading straight at us with BILLIONS infected in the next 3 months (@IHME_UW)—while some hand-wave it’s slightly milder—all while many choose to stay ignorant of exponential math.🔥
2) REMINDER— “milder” won’t save us, even if it’s 50% milder — because the exponentially fast doubling time of #Omicron can easily swamp out a 50% lower severity by doubling the case count! And doubling in 2 days!
3) Specifically @IHME_UW predicts 3 billion infections over the next 3 months… exponential math of #Omicron is really sobering. And besides the deaths and hospitalizations- don’t forget all the #LongCovid
📍ADJUSTED SEVERITY of Omicron vs Delta—Need to discuss *intrinsic severity* versus *observed severity* of #Omicron, which reinfects & evasive against 2-vaccine shots. New 🇬🇧study found that after adjusting for factors, Omicron is only slightly intrinsically milder—2%-12% (red)👇
2) Let’s look at this way… the raw crude rates of Omicron vs Delta doesn’t reflect that Delta isn’t as evasive against vaccines— Omicron **looks** milder because breakthrough (and reinfected) people have higher protection from severe disease. But raw numbers don’t adjust that!
3) from earlier study we see that #Omicron is highly evasive against past immunity from surviving Alpha, Beta, or Delta variant. Little to no neutralization of Omicron among convalescent blood of those people. But they are milder—but this hides the true severity in raw rates.
Jeeez— UK’s #Omicron wave is so stratospherically huge… that today’s per capita incidence would be equal to ~515,000 new cases if the size of US! ➡️ more than DOUBLE the all time record ever seen in the Us! #COVID19
2) How bad is UK’s Omicron load? US’s all time high was an daily average of 250k set last winter in early January. UK’s per capita rate today at 515k US-equivalent blows that out of the water! By 2x!
3) And yes, hospitalizations rising in England. 6 month high.
⚠️“MILDER” will not save us from overwhelmed hospitals. NYC #COVID19 🏥admissions up ⬆️4x in a month. ➡️Even if it’s 50% milder, but double cases infected—same hospitalization. 📍What’s then the problem? #Omicron doubles every 1.5-2 days! You wipe out a mild benefit in <2 days!🧵
2) same in London, the earliest #Omicron epicenter in UK… hospitalizations have tripled since a month ago! People who tout the mild while ignoring the total infections have no business in epidemiology.
3) Remember runaway infections is what will slam us hard in the end for causing surging hospitalizations and deaths… and 3 billion projected infections from @IHME_UW in 3 months is mind boggling.
UK 🇬🇧 hospitalizations spiking —now the highest in over 6 months. But mild you ask? ➡️Even if it’s 50% milder, but you double the cases infected… you’re at same hospitalization. ⚠️What’s then the problem? #Omicron doubles every 1.5 days! You wipe out a mild benefit in <2 days!
2) To be clear the 6 month high stat is for England 🏴
3) Global #omicron infections estimated to be 3 BILLION cases in next 3 months says @IHME_UW