3/ So how many hospital admissions should we be seeing right now?
First, let's look at what's happened to the hospitalization rate in NYC since the awful days of March 2020.
It's gotten a LOT better (in part because we're better at testing and diagnosing COVID)
4/ In March/April 2020, looking at lagged hospital admissions vs cases reported, the ratio is 21%
You had to be pretty sick or lucky to get a COVID test
By the Alpha wave, it was down to 6.9% (less testing explains the super quiet summer bump)
Vaccines have two effects ...
5/ During this fall's Delta surge, vaccines protected a large part of the City's population from infection (reducing cases), but with an even bigger impact on severe illness, esp among the elderly
So the net is that hospitalization rate dropped to 4.9%
That's our baseline
6/ The Omicron surge in hospitalizations in NYC started its climb on December 13th.
(Only 11 days ago, but these have been long days)
From December 13-16th there were 42,624 cases by report date
(NYC provides different dataset with diagnosis date as well- 38,113 in that span)
7/ So we would a 5% hospitalization rate after a 5 day lag if Omicron follows the same impact as Delta on the NYC population.
That pencils out to between 1,870 and 2,090 expected hospital admissions.
we had 780.
That's about 58-63% less than expected
Confounders? a few
8/ We are probably undercounting cases
It's hard to get a PCR test in NYC right now, and so many more infections are going undiagnosed, or diagnosed only with rapid antigen kits, that aren't reported to public health
That would means an even lower hospitalization rate/ severity
9/ We may be over-counting COVID hospitalizations
A high attack rate for Omicron means a higher likelihood that patients will be incidentally found to be infected WITH omicron, not FROM it
Maybe 20% of COVID admits? That would mean a lower severity rate
10/ Finally, some of the COVID infections may actually still be Delta rather than Omicron, which would also imply a lower hospitalization rate for omicron itself
So based on early returns, it does seem that 3% or fewer of Omicron cases will be hospitalized
That could be a lot
11/ The hospital mortality rate for COVID was 29% during the awful March-April 2020 period, and has come down to 18% since with better protocols and less overwhelmed staff
But if hospital capacity falls as cases rise, it could get bad
CDC action today helpful given omicron
12/ Back of envelope- If Omicron surge and fall takes place over the next 6 weeks, could see something like 1.2M NYers infected, maybe 400,000 diagnosed
Even a 3% hospitalization rate would mean 12,000 hospitalizations (more than all NYS empty bed capacity rn), over 2,000 deaths
13/ That's a far cry from Mar-Apr 2020 when over 25,000 perished, but is what you might expect from a bad influenza season (which we might have as well this year)
As always, we need to get boosters in arms (esp nursing homes), N95 masks for high risk, and try to ride it out 🙏
14/ [NB: I would have liked to add a comparison to Emergency Department Respiratory Syndrome visits, but the website is down??
After years of working reliably with mostly benign neglect this moment seems like terrible timing to be messing with it]
15/ Many thanks to friends on this website for adding great comments and links to other data analyses. I will add them to the thread for broader visibility
*Excellent analysis of "incidentals" from the UK (rising, ~30% of total) from @jburnmurdoch
16/ great point by @reichlab - preholiday testing may be catching infections sooner, could push out the usual relationship between cases and hospitalizations.
(Also read his thread using similar cross correlation analysis to find 3-5 day lag nationally)
1/ A big part of understanding the relationship between COVID cases and mortality is understanding the age structure of the waves
I've been looking at NYC "Respiratory" syndrome for ED visits (I was a member of the group that pioneered its use for public health 20 years ago)
2/ During prior influenza seasons, NYC would have up to 1,000 extra emergency department visits a day, much of the increase driven by babies and children (low prior immunity). Their share of ED visits would increase from ~20% to 40%
COVID19 was a completely different story
3/ Every day the number of ED visits rose higher. I remember seeing the first break in the relentless increase, and barely daring to believe that we had reached a peak. It was March 28. There were an extra 3,000 ED visits that day.
1/ The rate of Omicron infections in NYC is unprecedented.
I'd estimate 100,000 infections occurred ... yesterday. Maybe 300,000 over the past 10 days.
1% hospitalization rate would mean 3,000 admits to come over the next few days
I hope it's much less than that (86 so far).
2/ Complicating matters, after driving down influenza (and RSV) to undetectable levels last year, we let up on social distancing, masking, and they have come back
So at least part of the increase in ED visits and hospitalizations will be due to influenza/RSV (especially in kids)
3/ On the other hand, using COVID-specific hospitalizations may be overcounting "incidental" cases among those admitted (or dying) for other reasons, especially if very high attack rate for Omicron
They looked at UK COVID cases with (n=208,947) and without (n=15,087) the dropout associated w Omicron, and perform regression analyses to see what factors could predict Omicron
Date, for one
3/ for example, to predict whether a case is Omicron, you could find a clue by whether they are a reinfection (breakthrough).
There were 4,100 reinfections, but 36% of them were in the dropout group, compared w only 7% of the total cases. (OR 6.55 after controlling for all else)
1/ Omicron is ripping through America right now, to an extent we won't fully realize until later
At this point, I think most people can hope to delay infection, but not to avoid it.
I don't think herd immunity is a realistic goal anymore
Here's what I think it means for us
2/ Even as the Delta wave continues to kill over a thousand people a day, Omicron is already here, and there is no reason to believe that the explosive growth we have seen in other countries, and in local outbreak (like Cornell University) isn't happening across the US already.
3/ an Intrinsic infectiousness that is perhaps 2-3 times higher than Delta, with a short incubation time, and at least some measure of immune escape- means that we are unlikely to get Rt below 1 (and the outbreak quenched) before it rips through a large proportion of susceptibles
We've often heard people say something like "this innovative new service/company is good for patients and saves money, but there's no business model for it/ current reimbursement doesn't support it"
Step 1: Let's generate examples:
2/ I'll start.
But this is a group exercise, I need your nominations. Please try to give suggestions with some evidence behind them
*Advanced Care Planning
*Hospital at home
*Diabetes prevention program
*"SDOH" care navigation
(Used to be, telehealth)
3/ great work, tweeple
Clearly no shortage of ideas (with varying level of evidence) for things that could save money and be good for patients
The view espoused by many (including yours truly) has been that these services will flourish under value-based care