1/ We are all seeing the massive wave of Omicron sweep through our communities

Severity will make the difference between a bad winter and a horrific one

We keep saying "hospitalizations are still low, but it's early"

When is it time?

In NYC, it should be showing now.
2/ If you look at the counts of COVID cases and subsequent hospitalizations, they tend to track each other quite closely, but with a lag of 5-6 days

Deaths follow hospitalizations, by about 12 days. (it's too soon for that)

[Big props to my alma mater @nycHealthy for #opendata]
3/ So how many hospital admissions should we be seeing right now?

First, let's look at what's happened to the hospitalization rate in NYC since the awful days of March 2020.

It's gotten a LOT better (in part because we're better at testing and diagnosing COVID)
4/ In March/April 2020, looking at lagged hospital admissions vs cases reported, the ratio is 21%

You had to be pretty sick or lucky to get a COVID test

By the Alpha wave, it was down to 6.9% (less testing explains the super quiet summer bump)

Vaccines have two effects ...
5/ During this fall's Delta surge, vaccines protected a large part of the City's population from infection (reducing cases), but with an even bigger impact on severe illness, esp among the elderly

So the net is that hospitalization rate dropped to 4.9%

That's our baseline
6/ The Omicron surge in hospitalizations in NYC started its climb on December 13th.

(Only 11 days ago, but these have been long days)

From December 13-16th there were 42,624 cases by report date

(NYC provides different dataset with diagnosis date as well- 38,113 in that span)
7/ So we would a 5% hospitalization rate after a 5 day lag if Omicron follows the same impact as Delta on the NYC population.

That pencils out to between 1,870 and 2,090 expected hospital admissions.

we had 780.

That's about 58-63% less than expected

Confounders? a few
8/ We are probably undercounting cases

It's hard to get a PCR test in NYC right now, and so many more infections are going undiagnosed, or diagnosed only with rapid antigen kits, that aren't reported to public health

That would means an even lower hospitalization rate/ severity
9/ We may be over-counting COVID hospitalizations

A high attack rate for Omicron means a higher likelihood that patients will be incidentally found to be infected WITH omicron, not FROM it

Maybe 20% of COVID admits? That would mean a lower severity rate

samrc.ac.za/news/tshwane-d…
10/ Finally, some of the COVID infections may actually still be Delta rather than Omicron, which would also imply a lower hospitalization rate for omicron itself

So based on early returns, it does seem that 3% or fewer of Omicron cases will be hospitalized

That could be a lot
11/ The hospital mortality rate for COVID was 29% during the awful March-April 2020 period, and has come down to 18% since with better protocols and less overwhelmed staff

But if hospital capacity falls as cases rise, it could get bad

CDC action today helpful given omicron
12/ Back of envelope- If Omicron surge and fall takes place over the next 6 weeks, could see something like 1.2M NYers infected, maybe 400,000 diagnosed

Even a 3% hospitalization rate would mean 12,000 hospitalizations (more than all NYS empty bed capacity rn), over 2,000 deaths
13/ That's a far cry from Mar-Apr 2020 when over 25,000 perished, but is what you might expect from a bad influenza season (which we might have as well this year)

As always, we need to get boosters in arms (esp nursing homes), N95 masks for high risk, and try to ride it out 🙏
14/ [NB: I would have liked to add a comparison to Emergency Department Respiratory Syndrome visits, but the website is down??

After years of working reliably with mostly benign neglect this moment seems like terrible timing to be messing with it]
15/ Many thanks to friends on this website for adding great comments and links to other data analyses. I will add them to the thread for broader visibility

*Excellent analysis of "incidentals" from the UK (rising, ~30% of total) from @jburnmurdoch

16/ great point by @reichlab - preholiday testing may be catching infections sooner, could push out the usual relationship between cases and hospitalizations.

(Also read his thread using similar cross correlation analysis to find 3-5 day lag nationally)

17/ a caution

I'm talking specifically about NYC, a highly vaccinated community

Per @Bob_Wachter, SF has perhaps an even greater dissociation between cases and admissions.

But if the relatively lower severity is due to vaccines, then less vacc communities would be hit harder

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Farzad Mostashari

Farzad Mostashari Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Farzad_MD

21 Dec
1/ A big part of understanding the relationship between COVID cases and mortality is understanding the age structure of the waves

I've been looking at NYC "Respiratory" syndrome for ED visits (I was a member of the group that pioneered its use for public health 20 years ago)
2/ During prior influenza seasons, NYC would have up to 1,000 extra emergency department visits a day, much of the increase driven by babies and children (low prior immunity). Their share of ED visits would increase from ~20% to 40%

COVID19 was a completely different story
3/ Every day the number of ED visits rose higher. I remember seeing the first break in the relentless increase, and barely daring to believe that we had reached a peak. It was March 28. There were an extra 3,000 ED visits that day.

But even worse, they were almost adults.
Read 9 tweets
21 Dec
1/ The rate of Omicron infections in NYC is unprecedented.

I'd estimate 100,000 infections occurred ... yesterday. Maybe 300,000 over the past 10 days.

1% hospitalization rate would mean 3,000 admits to come over the next few days

I hope it's much less than that (86 so far).
2/ Complicating matters, after driving down influenza (and RSV) to undetectable levels last year, we let up on social distancing, masking, and they have come back

So at least part of the increase in ED visits and hospitalizations will be due to influenza/RSV (especially in kids)
3/ On the other hand, using COVID-specific hospitalizations may be overcounting "incidental" cases among those admitted (or dying) for other reasons, especially if very high attack rate for Omicron

(got to rerun excess mortality analysis, @WeinbergerDan)
jamanetwork.com/journals/jamai…
Read 6 tweets
18 Dec
1/ The wide range of predictions here is appropriate given how little we know about severity.

Many are pointing to the @imperialcollege @nfergus study as support for a belief that Omicron has similar severity than Delta.

I don't think it does.

Let's dig in
2/ the paper is here if you want to read it for yourself. imperial.ac.uk/media/imperial…

They looked at UK COVID cases with (n=208,947) and without (n=15,087) the dropout associated w Omicron, and perform regression analyses to see what factors could predict Omicron

Date, for one
3/ for example, to predict whether a case is Omicron, you could find a clue by whether they are a reinfection (breakthrough).

There were 4,100 reinfections, but 36% of them were in the dropout group, compared w only 7% of the total cases. (OR 6.55 after controlling for all else)
Read 9 tweets
17 Dec
1/ Omicron is ripping through America right now, to an extent we won't fully realize until later

At this point, I think most people can hope to delay infection, but not to avoid it.

I don't think herd immunity is a realistic goal anymore

Here's what I think it means for us
2/ Even as the Delta wave continues to kill over a thousand people a day, Omicron is already here, and there is no reason to believe that the explosive growth we have seen in other countries, and in local outbreak (like Cornell University) isn't happening across the US already.
3/ an Intrinsic infectiousness that is perhaps 2-3 times higher than Delta, with a short incubation time, and at least some measure of immune escape- means that we are unlikely to get Rt below 1 (and the outbreak quenched) before it rips through a large proportion of susceptibles
Read 17 tweets
23 Oct
1/ Let's do an exercise together:

We've often heard people say something like "this innovative new service/company is good for patients and saves money, but there's no business model for it/ current reimbursement doesn't support it"

Step 1: Let's generate examples:
2/ I'll start.

But this is a group exercise, I need your nominations. Please try to give suggestions with some evidence behind them

*Advanced Care Planning
*Hospital at home
*Diabetes prevention program
*"SDOH" care navigation

(Used to be, telehealth)
3/ great work, tweeple

Clearly no shortage of ideas (with varying level of evidence) for things that could save money and be good for patients

The view espoused by many (including yours truly) has been that these services will flourish under value-based care

But not that easy
Read 19 tweets
20 Oct
The @AledadeACO annual awards!

1) Service.

Team Award: The Pharmacy Team!!
2) Accountability.

Individual Award:
Stephanie Sydorko (Tech Lead, Engineering)

Team Award:
CA-ledade (which has rapidly become our largest MSSP market)
3) Inclusion

Individual Award
Supreme Ally Commander
Michael Jones

Team Award
Health Equity Team (led by @kishadavismd)
Read 6 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(