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Marion Holman

@holmanm

4 Jan

1/4 This is ME, I would never EVER entertain a vaccine or any other pharma drug (Statins included). I have lived my life without these drugs, and have, so far, led a very healthy life.

2/4 This is an example of how it goes horribly wrong. "Have a patient in his 50s who had an MI and CABG. The cardiologist started him on a statin. His recovery has dragged on for months. He developed malaise, memory loss, muscle pain, elevated LFTs and lowered blood counts.

3/4 He is not the man he used to be. I told him these were all recognized S/Es of statins. His cardiologist, aware of these problems, has denied they could be S/Es and cautioned him that "it would be suicide" to stop the statin. The poor guy doesn't know what to do.

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Marion Holman

@holmanm

31 Dec 21

1/7 The acuteness of critical thinking depends on the number of causalities in one’s vocabulary and the number of precedents in one’s library.

Statins have long been pushed by pharmaceuticals and their public health lapdogs. Their rhetorical syllogism for public consumption has

2/7 been that blood cholesterol causes cardiovascular disease and Statins lower blood cholesterol without side effects and THEREFORE statins are beneficial. Some public health statinators even called for addition of statins to municipal drinking water systems.

3/7 But where is the evidence that lowering blood cholesterol decreases cardiovascular disease risk? Cholesterol is an essential element of cellular building and repair. Of course cholesterol and, eventually calcium, will collect at the sites of vascular injury—these are natural

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Marion Holman

@holmanm

30 Dec 21

1/4 So sad for these poor souls who still believe that ⬇️ Cholesterol = good health. “I started taking Repatha last July. I had been previously taking Lipitor. I had side effects especially muscle pain and joint pain. I had been stopped for about 5 months.

2/4 My current Cardiologist said I should try Repatha due to the low number of reported side effects. During second months injections (every two weeks) I felt mild muscle pain and weakness. I took Tylenol to help with the pain. It has become progressively more insidious.

3/4 Yesterday, 5 days from last injection I could not get out a chair, running nose, trouble walking, can't go up and down stairs, severe pain in ankles, knees, hips and back. loss of upper body strength, itching.

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Marion Holman

@holmanm

30 Dec 21

1/9 Chronic inflammatory diseases, such as rheumatoid arthritis, lupus, psoriasis, and infections, such as periodontal disease p.gingivalis & HIV, are associated with an increased risk of CVD. Patients with these disorders also have an increase in coronary artery calcium

2/9 measured by CT & carotid intima media thickness measured by ultrasound. WHY ?? Because inflammation & infections induce a variety of alterations in lipid metabolism that may initially DAMPEN inflammation or fight infection, but if chronic could contribute to the increased
/3

3/9 risk of atherosclerosis. The changes in lipids and lipoproteins that occur during inflammation & infection are part of the innate immune response & therefore are likely to play an important role in PROTECTING the host.
/4

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Marion Holman

@holmanm

29 Dec 21

1/4 Ethan Weiss on Statins: Not sure if to laugh or cry. "And the statin trial comes with an important condition: the drug must not make people feel bad. I tell patients that statins are probably the best studied class of medicines in history" 😂😂😂

2/4 "My read of the data suggests that they are safe (they will not cause adverse events) except small effects on blood sugar which are real but small. I tell people that we will focus then on tolerability"

3/4 My thoughts: What planet does he inhabit ? He hasn't read the data, or he hasn't understood it, he has absolutely no idea about the mechanism of action of Statin drugs, and no clear idea about what actually causes heart disease. This guy lives in cloud cuckoo land.

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Marion Holman

@holmanm

29 Dec 21

1/7 Read this, read it again, and understand it.
To me it is mindblowing. It points to the fact that lipids are PROTECTIVE. Part of the innate immune response, and it makes the 'infective cause' of CVD far more plausible.

2/7 Lipoprotein particle levels and their constituents are extensively altered by acute inflammation and infection (Gabay and Kushner, 1999). In fact, hypocholesterolemia (low cholesterol) has been consistently correlated with WORSE outcomes in critically ill patients

3/7 (Windler et al., 1994; Gordon et al., 2001; Gui et al., 1996; Marik, 2006). The molecular mechanisms underlying this are poorly understood but measurements of various lipid parameters in patients with severe sepsis or septic shock indicate that apoB lipoprotein levels can

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