Chronic social isolation and loneliness drives hyper dynorphin and calcium-glutamate biochemistry
https://twitter.com/NeuroscienceNew/status/1479964369408638981
Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System. europepmc.org/article/MED/26…
Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers nature.com/articles/s4138… 
I experienced this firsthand after my brain injury and being in a toxic relationship, I was totally isolated from all family and friends.
Modulating the KOPr, GABAr, and glutamate receptor systems was crucial to my survival during this time.
Modulating the KOPr, GABAr, and glutamate receptor systems was crucial to my survival during this time.
I had to reverse engineer the underlying biochemistry involved until I got out of that relationship and reconnected with my family.
Especially being an addict at the time, I noticed modulating these receptor systems also reduced my cravings for drugs.
KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway. europepmc.org/article/PMC/PM…
That initial chronic social isolation thread is what I found to effective in my own case and now it’s helped hundreds of people since lockdowns began.
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