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Eric Topol Profile picture
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Jan 15,, 6 tweets, 5 min read
The remarkable story of how it took multiple decades of perseverance to make the mRNA Covid vaccines a reality
nytimes.com/2022/01/15/hea…
Pioneers @kkariko and @WeissmanLab led the way with their 2005 @ImmunityCP paper, rejected by @nature and @ScienceMagazine
My summary of the significance of that classic paper
cell.com/immunity/fullt…
Here's a great timeline for how the mRNA Covid vaccines ultimately got developed
@ElieDolgin @nature nature.com/articles/d4158…
And an excellent review article of mRNA vaccines for infectious diseases, by @namit__c and colleagues
It took the front page and 3 more pages to begin to tell the story of this "long buried science"
Another very good timeline (and review paper) showing the mRNA and lipid nanoparticle development over 5 decades to get to the Covid vaccines
nature.com/articles/s4157…

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More from @EricTopol

Eric Topol Profile picture
Jan 11,
First report of US outcomes for Omicron: ~53,000 cases in Southern California (vs Delta), consistent w/ S Africa and UK
medrxiv.org/content/10.110…
~50% less hospital admission from ER/out-patient
~75% less ICU admission
~70% reduction in hospital length of stay
Evidence for vaccine protection vs Omicron symptomatic hospital admission (For Covid) among cases tested in outpatient settings
This is all good news to confirm reports from South Africa, UK, Denmark, Israel, and other countries.
But please do not forget that when there's 5-10X cases, there's still an overload of ER visits/hospital/ICU admissions.
Especially among unvaccinated and vaccinated, waned.
Read 4 tweets
Eric Topol Profile picture
Jan 6,
The US vaccine booster rate is dreadfully low
@OurWorldinData
You will see that play out by many vaccinated, waned, hospitalized patients
(already happening, but it's a country without data)
Vaccine effectiveness vs hospitalization with Omicron infection
2-shot 52%
3-shot 88%
That the US has not made "fully vaccinated"= 3 shots ignores these data and will lead to a large number of preventable hospitalizations
erictopol.substack.com/p/humans-2-omi…
Illustrating this important issue, the current rise of hospitalizations in a large health system among vaccinated, waned vs vaccinated, boosted
Read 4 tweets
Eric Topol Profile picture
Jan 6,
I keep looking at New York State as the indicator for what's to come in the US. For new cases/capita, it's leading the US. If it were a country, it would now be the 2nd highest in the world after Ireland. In contrast to the CDC, the state has a lot of solid new data to review /1
Hospitalizations are rising, sharply
The level of patients requiring ICU beds is nearly as high as the monster 3rd wave (well below the 1st wave) /2
newsnodes.com/us_state/NY
coronavirus.health.ny.gov/daily-hospital…
NYS "fully vaxx" rate is 72% and also has better than US avg for older age groups.
There's some reduction of vaccine effectiveness vs hospitalization recently, but the overwhelming proportion of patients admitted are among the unvaccinated /3
Read 5 tweets
Eric Topol Profile picture
Dec 22, 2021
Paxlovid just cleared by FDA!
Will be available in days
Just not enough of it to go around and that needs to be fixed ASAP
This is big, folks 👋👍👍
For more than a year we've been talking about Global Vaccine equity.
Now it'll also be Global Pill Equity.
Unless something is done to get production revved up, as discussed here
theguardian.com/commentisfree/…
Read 4 tweets
Eric Topol Profile picture
Dec 22, 2021
Omicron resulting in less severe illness
The latest roundup of data from this preprint with South Africa data and from Denmark ft.com/content/19065f… by @mroliverbarnes @jburnmurdoch @rmilneNordic
1. Less hospital admission in South Africa
2. Also 3X less likely in Denmark, but with a skew towards younger people testing positive
Also of note is the higher vaccinated proportion with Omicron in Denmark than was the case with Delta and prior variants
Read 7 tweets
Eric Topol Profile picture
Dec 20, 2021
Last week @CDCgov reported Omicron was 2.9% (that has now been revised)
*Today it is 73%*
Dominant across the US (with heterogeneity)
This is a doubling growth rate of 2 days or less
Replicates what has been seen in South Africa, UK, Denmark
Last week's 2.9% of cases being Omicron has been revised upward to 12.6%
12.6% -->73% of new cases are now Omicron
That's what you call exponential growth, folks
Yes, you read it right, a whopping 73%
Read 5 tweets

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