Thread by @trikomes

🧵"Psychoplastogens" = drugs that rapidly induce physical changes in the brain (neuroplasticity).

Examples: ketamine, psilocybin, LSD, DMT, MDMA.

Neuroscientists can literally watch new connections sprout overnight, as in the example below.

Movie:

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There are other plasticity-promoting psychoactive drugs, such as SSRIs, that are not psychoplastogens because they induce plasticity on a slower time scale (weeks).

Psychoplastogens can stimulate plasticity when exposed to neurons for <1 hour.

pubs.acs.org/doi/abs/10.102…

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I first learned about this term from the work of @DEOlsonLab.

I discussed his research with him in a recent podcast conversation, including his work on #psychedelics like ibogaine.

Listen here:

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I have discussed other psychoplastogens, like #psilocybin, with neuroscientists like @kwanalexc.

In that conversation, Dr. Kwan shared some fascinating microscopy videos of neurons in mice.

Watch here:

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I also learned about ketamine, and how it compares to traditional depression medications like SSRIs, in a conversation with @LisaMonteggia:

Listen here:

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To stay up-to-date on this general area of research, you can sign up for my free weekly newsletter, where I share some of the latest research and provide tools so you can freely access this information:

mindandmatter.substack.com

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