⚠️Listen up—Top 🇬🇧 scientists warns that “In the last week—there’s now evidence that T-cells…get damaged the same way that HIV and other RNA-virus damage T-cell immunity”. ➡️Prof Costello (@globalhlthtwit) raises serious concerns on #COVID19 & the 🧠—a🧵:
2) “My biggest worry all along has been the long term effects particularly on the brain. We know that people who get brain fog who get fatigue, cognitive problems, & smell and taste is very common—and that means the virus is affecting the brain 🧠”
3) “We know the virus can get intro the brain. We know the virus affects cells around blood vessels. I’m beginning to think—‘how long is this going to last’—because we have allowed millions of children to become infected with the virus.”
4) “And as @ArisKatzourakis said earlier, there’s **NO** real hard evidence [Omicron] is less virulent than delta in absence of vaccination! Now children have not (all) been vaccinated” 👀
5) What are some of the studies? Lots of basic science papers, but here is one study showing T cell death abnormality below… which contributes to #LongCovid
6) There is a surging mountain ⛰ of evidence on both #LongCovid - and particularly in kids. Notably, #LongCovidKids has tripled in kids in 6 months, and kids suffering longer than a year have DOUBLED! 👇 the Uk govt data doesn’t lie…
8) “We know Epstein-Barr Virus causes multiple sclerosis. We know chickenpox causes shingles. We know that measles in a few children causes very nasty neurodegeneration… Zika virus destroying the brains of babies. Viruses are risky. What worries me is the scale of this virus.”👀
9) What’s the latest evidence that EBV causes multiple sclerosis? This Harvard-led study published in Science that found a 32-fold higher risk of developing MS with EBV. For context, smoking a pack a day & lung cancer risk is only around 10-15-fold. 32 fold is off the charts!
10) “From previous waves we believe 7% to 10% developed long COVID, but with Omicron, the numbers being infected are so high that even if just 1% of infected children get long COVID, ➡️ it’ll cause more pediatric long COVID cases than Delta.” 👀 timesofisrael.com/1st-kids-omicr…
11) With Omicron spreading fast in schools and other places where kids mix, significant hospitalizations are inevitable, according to Dr. Moshe Ashkenazi. “the sheer numbers being infected will mean children being hospitalized”
12) Let’s rewind time — scientists warned in mid-2020 that the “Coronavirus Short-Circuits the Immune System—In a disturbing parallel to H.I.V., the coronavirus can cause a depletion of important immune cells, recent studies found.” ➡️yet we ignored. 🤦🏻♂️ nytimes.com/2020/06/26/hea…
13) Notably, “In May 2020, Dr. Wherry and his colleagues posted online a paper showing a range of immune system defects in severely ill patients, including a loss of virus-fighting T cells in parts of the body.” doi.org/10.1101/2020.0…
14) “In a separate study, the investigators identified three patterns of immune defects, and concluded that T cells and B cells, which help orchestrate the immune response, were inactive in roughly 30% of the 71 Covid-19 patients they examined”. (May 2020) biorxiv.org/content/10.110…
15) I remember when some doctors made parallels to “airborne HIV”— while we now know #SARSCoV2 isn’t exactly same as HIV, it seems it definitely is very airborne & very harmful to T-cell immunity. ➡️ DO NOT RISK COVID—we don’t know what its #LongCovid is capable of!
16) Moral lesson, always be wary when someone hand waving dismisses #COVID19 as “mild” whenever they couldn’t have possibly had enough data to really know for sure.
17) **with caption** - listen to Professor Costello explain why he is so worried about #COVID19 damaging T cells and #LongCovid concerns for the brain.
18) P.s. it’s not just T cell damage of COVID. It’s also vascular damage too. Case in point. 👇
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain.
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention.
2) RFK Jr told Trump today there’s now 2 measles deaths.
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏
2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)
2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)." nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.
"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts.
2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...
If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here. cdc.gov/fluvaxview/das…
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.