Alina Chan Profile picture
Jan 18 16 tweets 5 min read
What are the chances of someone catching COVID from international mail?

I'd say it's near impossible unless they were aerosolizing + inhaling their letters.

"contact with a contaminated surface has less than a 1 in 10,000 chance of causing an infection"
cdc.gov/coronavirus/20…
If scientists are too fixated on mythical SARS-CoV-2 transmission via international mail, they might miss the actual community transmission of the virus.

This is unless there is somehow a new trend where people are mailing sputum to each other internationally.
There's also no study outside of China, afaik, that cites any evidence of cold chain transmission of Covid #PopsicleOrigins

The one non-China preprint was conveniently withdrawn in March 2021 right after being cited by the China-WHO joint study. biorxiv.org/content/10.110…
If your local scientists/investigators are telling you that sporadic covid cases in your city are from cold chain or international mail, you might be rightly concerned that they're covering up or not doing due diligence to find the real source of infection threatening the city.
Even if you invaded a covid patient's house and found it stacked from floor to ceiling with Maine lobster, Faroe Salmon and letters from Hogwarts, it is still thousands of times more likely that they caught the virus the regular way through the air/close contact with an infected.
Selling the narrative to your people (and youth) that a sporadic Covid case came from frozen food / international mail, as opposed to the highly plausible transmission of the virus via millions of travelers (by land, sea, air) might compromise their critical thinking abilities.
These kinds of misinformation can stick in the minds of children and hurt their ability to think logically in the future. Imagine an entire generation of children being raised to think that they can catch SARS from frozen seafood or international mail.
Flight attendants broke quarantine in Hong Kong, tested + for Omicron after being in community.

Totally plausible + expected way for SARS-CoV-2 to breach zero covid. Probably other travelers breaching restrictions.

No need to blame sporadic cases on ✉️
cnn.com/2022/01/18/bus…
Some have said the 1/10,000 risk of fomite transmission cited by the US CDC was too high, so I went to check their citations.

1st paper
"Infection risks ranged from 2 in 10,000,000 to 4 in 10,000"
pubs.acs.org/doi/10.1021/ac…
"We did not attempt to culture live virus from any of our surface samples and therefore cannot determine the viability or infectivity of the SARS-CoV-2 detected in our samples."

Then how did you estimate the infection risks?
2nd paper also did not check whether their surfaces were actually contaminated by live virus.
ajicjournal.org/article/S0196-…
Last paper does check for infectious virus after exposure to humidity/heat, and rightly states "the infectious dose of SARS-CoV-2 is currently unknown and thus it is difficult to evaluate the risk of infection following contact with a contaminated fomite."
journals.asm.org/doi/10.1128/mS…
None of these 3 citations in the US CDC website can really tell us what the risk of catching COVID from a contaminated surface is because there is no evidence pointing to fomite transmission.

But I would say it's accurate that it is certainly "LESS THAN a 1 in 10,000 chance".
Still it would be more accurate if the US CDC and other health organizations would inform the public that they have zero evidence of anyone having caught Covid from a contaminated surface.
We are 2 years into the pandemic. How is it that scientists/public health organizations are still having such a hard time communicating to the public how to effectively protect themselves against Covid transmission?
If people are misinformed and spend their efforts disinfecting their frozen seafood or international mail, as opposed to protecting themselves against actual sources of the virus, this is a major public health failure.

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More from @Ayjchan

Jan 19
Proximal Origin failed to acknowledge experts who convened its authors, made natural #OriginOfCovid arguments on Feb 1 call, and/or provided input on the work.

@Akselfrids asked @NatureMedicine if they were considering an addendum to Proximal Origin...
minervanett.no/politikk-begra…
"We do not at this time intend to come up with an addendum to the article... The journal is still open to assess a diversity of views on any issue... the publication of new solid research which, according to expert assessment, can help us understand the origin of the virus."
How many manuscripts arguing that a lab #OriginOfCovid is plausible has @NatureMedicine received and sent for peer review? May we at least have numbers of submissions, peer reviews, and rejections if the peer reviews themselves cannot be made public?
Read 10 tweets
Jan 19
"The entire clause that suggested that the WHO should have speedy access to disease outbreak sites has been removed – at the insistence of China"

In other words, let's repeat the devastating mistakes made this time round when the next pandemic occurs.
healthpolicy-watch.news/report-on-pand…
Countries that refuse to admit independent international investigators when an outbreak has been detected are putting the entire world at risk for another pandemic.

This is dangerously irresponsible, anti-scientific, and not a sign of technological or moral leadership.
We should not have a repeat of this:
Read 5 tweets
Jan 16
It appears that the people who convened the Proximal Origin authors who staunchly dismissed a lab #OriginOfCovid may have also shaped the membership of the @WHO team that went to China and ruled a lab origin as extremely unlikely. h/t @CDommasch
s3.documentcloud.org/documents/2079…
@WHO @CDommasch On Feb 5, 2020, Farrar writes to NIH/NIAID leaders, asking for "names to be put forward into the [WHO #OriginOfCovid] Group from us and pressure on this group from your and our teams next week."

One of the Feb 1 call participants ended up on the WHO team.
@WHO @CDommasch It looks like they might've put forward the names of more participants on the Feb 1 call, but no others were selected.
Read 17 tweets
Jan 13
One of the Proximal Origin authors told @theintercept that their letter has "held up extremely well".

Really? Aside from the messy reveal of the origin of Proximal Origin, has the scientific content held up at all?
theintercept.com/2022/01/12/cov…
We know Wuhan scientists were serial passaging novel viruses in a range of cell lines.

We know they were part of a collaboration with a roadmap for inserting novel cleavage sites into novel SARS-like viruses.

We know they had direct & exclusive access to SARS2-like viruses.
We know that we have barely any insight into the viruses discovered by the Wuhan Institute of Virology after 2016.

We know that they were culturing, genetically engineering SARS-like viruses, and performing infection experiments in cells and animals at low safety BSL2 or 3.
Read 5 tweets
Jan 12
The questions in this letter are not specific or productive if directed at the leaders of NIH/NIAID.

The priority should be to secure a commitment from NIH/NIAID to publicly release the Feb 4, 2020 draft of Proximal Origin and the fully unredacted emails.
republicans-oversight.house.gov/wp-content/upl…
None of the 7 questions ask specifically what the perceived competing interests in the Feb 1 group are, ie, what the impact of a lab #OriginOfCovid would be on the participants' careers and reputations; why several contributors went completely unacknowledged in Proximal Origin.
None of the 7 questions ask specifically what corrective actions should be taken while this issue is being resolved, eg, editor's note on Proximal Origin, recusal of Feb 1 participants from all academic/advisory activities relating to #OriginOfCovid
Read 15 tweets
Jan 12
I'm all ears to hear about the precise scientific process that occurred between Feb 2 and Feb 4, 2020 where top experts in virology and evolutionary biology completely changed their minds about the likelihood of SARS-CoV-2 emerging from a lab.
In Jeremy Farrar's book, he noted that Marion Koopmans had said furin cleavage site insertions happen in viruses all the time naturally.

Kristian Andersen, lead author of Proximal Origin, said just because it happened in nature did not rule out unnatural origins.
By the time Proximal Origin was published (i.e., the final paper), Koopmans argument had been absorbed into the manuscript without acknowledgement.

"insertions.. can occur.. the polybasic cleavage site can arise by a natural evolutionary process."
nature.com/articles/s4159…
Read 8 tweets

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