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Prof. Jose-Luis Jimenez Profile picture
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Jan 23 • 5 tweets • 2 min read
Of course it is neurotropic, see e.g.: pubmed.ncbi.nlm.nih.gov/34189535/

70 years ago this fellow would have told us that polio was not neurotropic, because only 1% of the cases have serious complications of that type...
frontiersin.org/articles/10.33…
researchsquare.com/article/rs-113…
nature.com/articles/s4159…

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Prof. Jose-Luis Jimenez Profile picture
Jan 24
1/ A big COVID outbreak takes 2 ingredients:

- someone highly infective (most infected people don't seem to be infective or little; the highly infective are so during a short period)

- The right indoor conditions for accumulating and breathing in the virus.
2/ In this paper we showed that the outbreaks that have complete data for analysis are explained by airborne transmission in shared indoor air

[Detailed explanation on that thread]

3/ The level of virus in the air is analogous to the level of water in a sink, depends on:

- faucet: emission rate of virus

- size of sink: volume of room

- size of drains: ventilation, filtration etc.

[Analogy not perfect but good for illustration]

Read 7 tweets
Prof. Jose-Luis Jimenez Profile picture
Jan 24
1/ @Nature: "COVID-19: endemic doesn’t mean harmless"

"The word ‘endemic’ has become one of the most misused of the pandemic. And many of the errant assumptions made encourage a misplaced complacency."

By @ArisKatzourakis

nature.com/articles/d4158… Image
2/ "A disease can be endemic and both widespread & deadly. Malaria killed more than 600,000 ppl in 2020. 10M fell ill with tuberculosis that same year & 1.5M died. Endemic certainly does not mean that evolution has somehow tamed a pathogen so that life simply returns to ‘normal’" Image
3/ "There is a widespread, rosy misconception that viruses evolve to become more benign. This is not the case: there is no predestined evolutionary outcome for virus to become more benign, especially ones, such as SARS-CoV-2, in which most transmission happens bf severe disease" Image
Read 5 tweets
Prof. Jose-Luis Jimenez Profile picture
Jan 23
Of course children need masks. COVID is not a cold. It is a neurotropic virus, can go into the brain and lots of other organs. 1000 children dead in US, millions of kids w/ #LongCovidKids, millions have lost parents.

Wearing mask is not hard for kids, they forget about it.
And this person is a doctor? And @BBCNews gives a platform to an someone with this level of ignorance?
#COVIDisNOTaCold

Read 20 tweets
Prof. Jose-Luis Jimenez Profile picture
Jan 21
1/ Sobre la transmisión de virus a muy gran distancia, como decía este señor que podía explicar que hubiera e.g. más casos en Cataluña vs. otras comunidades.

He dicho que es una tontería, y lo mantengo. Explico algunos detalles aquí:
2/ Esta es una pandemia DE INTERIORES. El virus se transmite por el aire, pero sobre todo hablando cerca o al compartir una habitación (como todos los casos de superpropagación), como en la imagen.

Muchos más detalles aquí:
3/ Hay bastantes casos documentados de transmisión por el aire a más distancia en interiores (sin estar en la misma habitación al mismo tiempo), por ejemplo en hoteles de cuarentena en Nueva Zelanda, Hong Kong etc. Como este caso por flujos bajo puertas:

Read 13 tweets
Prof. Jose-Luis Jimenez Profile picture
Jan 20
1/ THE PENDULUM OF HISTORY OF AIRBORNE TRANSMISSION

As we revise our paper on this (papers.ssrn.com/sol3/papers.cf…), we've added draft diagram to summarize the history visually:

It'll be a few more days till we submit, so please reply with comments, clarifications, suggestions etc.
2/ If you haven't seen this, the short version:

- From Hippocrates and during most of human history, diseases were thought to transmit through the air (via a miasma)

3/ Miasma theory dominates till mid to late 1800s:

Cholera, Puerperal Fever, and Malaria (literally "Bad Air" in medieval Italian) were thought to transmit through the air. But demonstrated to transmit via water, hands, and mosquitos, respectively.

Read 19 tweets
Prof. Jose-Luis Jimenez Profile picture
Jan 19
@CIBSE_NatVent I have run the case on our estimator at docs.google.com/spreadsheets/d…

- Note ventilation rate is relatively high, most schools don't meet it

- Leads to CO2 = 1720 ppm, while some of your colleagues in the UK say it is fine if it is < 5000 ppm

Vent rate for 5000 ppm is 1 l/s/p, NOT 5
@CIBSE_NatVent With 5 l/s/p, adding the RELATIVELY SMALL cleaner with CADR = 100 l/s (ACH = 2.4 on cell B31) the risk goes down 30%

With an EXPONENTIALLY growing disease, that's a lot, because it is 30% off EACH GENERATION. I.e. compound interest
@CIBSE_NatVent With the "barely acceptable according to some UK experts" case with 4999 ppm CO2 (~1 l/s/p), then adding that smaller air cleaner reduces the risk 45%.

I would definitely prefer to have my son in a class with the cleaner than without the cleaner
Read 5 tweets

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