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Tracy Høeg, MD, PhD Profile picture
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Jan 25 • 5 tweets • 2 min read
“We need to make sure schools are safe” said @DrPanMD about mandating vax for all school kids in California
For a vax that doesn't prevent transmission & has yet-to-be-fully-defined side effects, requiring it for kids to get an education is non-sensical🧵
latimes.com/california/sto…
1. Vax does not prevent infection
2. Those already infected gain no clear additional protection against severe disease from vaccination
3.There is still ongoing international discussion about what is safest/best for children 5-11. See Norway
4. If you want to focus on child safety, then focus on normalcy and lack of interrupted education for mental, social and emotional health and allow children & families to decide on the doses and timing of vaccination w/their pediatricians based on individual risk factors.

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More from @TracyBethHoeg

Tracy Høeg, MD, PhD Profile picture
Jan 22
🇩🇰New important Danish data
-HIGHER rates of infection among vaccinated 5-11 yos, even when adjusting for testing rate
-Boosters not associated w/lower infection rates
🟠unvaccinated
🔵2 doses
🟢booster
Data on severe disease & thoughts on mandates 👇
covid19danmark.dk/#gennembrudsin…
Here are COVID ICU (left) & hosp (right) admissions by vax category & age. Boosters have no clear association w/severe disease <age 40-50. This is consistent w/ Israeli data published in NEJM which found no significant correlation w/severe disease <age 40 nejm.org/doi/full/10.10…
Given the above, it's hard to argue college booster mandates are based in science. And, given even small risk of severe adverse events, are unethical. So this explanation 👇 sadly makes more sense than anything based in good public health or compassion
Read 7 tweets
Tracy Høeg, MD, PhD Profile picture
Jan 14
So, is myocarditis after vax more common than after covid in 12-17 yo boys?
Let's look at the two studies they are discussing
I would tend to agree w/ @joerogan the better-designed study is the one from Oxford showing myo after vax more than after covid in males <40
Here's why🧵
The oxford study is a re-analysis of a paper published in @Nature (link in tweet below) where they had 38 million people from the UK over 8 months who they knew the vax/myo diagnosis/covid + status. Reanalysis found myo>after vax than covid in males 16-39
The 2nd study identified only *6* cases of post-covid myo over *a year* in males 12-17 in a hospital system w/a cachement of 60 million people. They provided an inappropriately low estimate of # infected giving inappropriately high rate of post-covid myo medrxiv.org/content/10.110…
Read 6 tweets
Tracy Høeg, MD, PhD Profile picture
Jan 11
Now, using new 0.48 hazard ratio for hosp w/omicron, we get
1/5000 risk of covid hosp requiring treatment for 12-17 yo w/o comorbidities pre vax
Hong Kong & Kaiser data 1/2700 risk of post dose 2 vax myo boys 12-17
If vax doesn't stop transmission, how is this ethical to mandate?
Considering the above, I wonder why we are not asking "should all teen boys get vaxed" with mRNA vaccines? For example, what about children who have already been infected? Agree w/@walidgellad "benefits vary patient by patient"
theatlantic.com/health/archive…
Here are the Kaiser data on omicon's decreased severity:
Read 6 tweets
Tracy Høeg, MD, PhD Profile picture
Jan 5
🇩🇰Updated data from Denmark showing highest rates of infection in those who have received *boosters* who are >40 yo
🟢booster
🔵2 doses
🔴previously infected
🟠unvaccinated
But see adjustment for test # s below
Denmark now w/around 85% omicron
@SSI_dk (covid19danmark.dk/#gennembrudsin…)
The appearance of negative vax efficacy against infection has been puzzling, especially when separating out prev infected, but @KT_Baek seems to be onto something⬇️ when he adjusts for # of tests taken; this gives v similar infection rates in all 4 groups

Though 2 & 3 doses of vax not effectively preventing infection, 2 doses evidently protecting against severe disease & death in adults & 3 doses seem to offer extra protection in those >70
👇 hospitalization & death rates/100,000 by vax status
🟢booster
🔵2 doses
🟠unvaccinated indlæggelser: hospitalizations
Read 5 tweets
Tracy Høeg, MD, PhD Profile picture
Dec 31, 2021
When considering boosters in children:
1 child/78 developed myo in the booster trial among 16-17 yos
& Pfizer's own analysis shows booster would
-prevent 29-69 hospitalizations/mill but would
-result in 23-69 vax myocarditis/mill in males 16-17
🤔Not a great ratio for most boys
Also remember myocarditis after Pfizer dose 2 & booster (and Moderna 1 &2) more common in males 16-39 than after Covid
And @MartyMakary makes an excellent point here about there not being a VRBPAC expert advisory committee meeting before the FDA authorizes boosters for 12-15 year olds
Read 4 tweets
Tracy Høeg, MD, PhD Profile picture
Dec 26, 2021
🇬🇧 The research group at Oxford who compared myocarditis rates after covid to after the vax (nature.com/articles/s4159…) have just released a new analysis:
In males 16-39,
Myocarditis more common after Pfizer dose 2 & 3
&
Moderna dose 2 than after infection medrxiv.org/content/10.110…
I'm already personally aware of 5 cases of post-booster myo in males 16-24; remember, this @NEJM study on boosters by age, the "rate of severe disease in the youngest age groups (16-39) was v low ...not enough cases to estimate the rate ratio reliably" nejm.org/doi/full/10.10…
Current college booster mandates do not seem to have the best interests of the students, especially the male students, at heart. We need better data on the risks and benefits of boosters in the <40 age group.
Read 4 tweets

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