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Eric Topol Profile picture
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Jan 25 • 4 tweets • 2 min read
ICU admits may be the best proxy for lack of vaccinations. Israel and the US have low rates of vaccination (65, 63%) and have seen rising ICU rates in their Omicron waves (not seen in high vaxx % countries)
@OurWorldInData Image
Clarification: Colors are swapped on the vaccine right-sided panels. Israel has slightly more 2-shot vaccination and >2X boosters
Important graph from @StavKislev that supports my point Image
And correction of the Israel ICU data, filling in of hospital admissions data by @OurWorldInData, via @KelleyKga Image

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More from @EricTopol

Eric Topol Profile picture
Jan 27
Important new @UKHSA report today sheds light on key Omicron concerns
assets.publishing.service.gov.uk/government/upl…
1. BA.2 Vaccine effectiveness holds up very well compared with BA.1 *with booster* Image
2. The vaccine effectiveness (VE) vs Omicron symptomatic infection vs Omicron falls off 15+ weeks, as was seen with the Israeli data, here more so with Pfizer compared to Moderna Image
3. But protection (VE) vs Omicron hospitalization remains quite high (Moderna > 90% thru 9 weeks) Image
Read 4 tweets
Eric Topol Profile picture
Jan 24
How to reduce your chance of dying from Covid by 99%?
Get vaccinated and a booster.
One of the most impressive graphs I've seen for the impact of vaccination in the US pandemic
(thanks @redouad @OurWorldinData for re-plotting my makeshift graph from earlier today)
Highlighting the data above are for all ages
Graphs for vaccination vs deaths by age groups (w/o booster partitioned):
Now deaths by age groups: 65+, 50-49, 18-49
For each group, death is reduced by 99% for vaccination plus booster compared with unvaccinated (down to zero for youngest age group)
ourworldindata.org/grapher/united…
Read 5 tweets
Eric Topol Profile picture
Jan 23
What to make of Omicron's BA.1 and (sister) BA.2 lineages?
Both are hyper-mutated with over 50 mutations but many are different, particularly in the spike and ORF1a regions outbreak.info /1
There's not any functional or epidemiological data to show any meaningful differences....yet. But BA.2 has become dominant in Denmark, out-competing BA.1, and its prevalence is rising in India, Singapore, Sweden, the UK and other countries /2 Graph via @Mike_Honey_
The spread of BA.2 supports increased transmissibility (hard to imagine beyond BA.1, O's sister). On Jan 21st, UK designated it as a variant under investigation ft.com/content/34fef1… More to learn, keep 👀, no reason for distress at this point (we already have enough of that)
Read 4 tweets
Eric Topol Profile picture
Jan 22
Debunking the notion that boosters don't reduce Omicron symptomatic infections. Another new study from Qatar shows they are halved medrxiv.org/content/10.110… matched >400,000 people with mRNA vaccines 2 vs 3-dose Image
The booster reduction for Omicron symptomatic infections for 3-dose vs 2-dose was 66% in the @JAMA_current report yesterday
jamanetwork.com/journals/jama/… Image
Booster vaccine effectiveness vs Omicron infections 62% (2 dose 32%) @UKHSA in people without Prior Covid
assets.publishing.service.gov.uk/government/upl…
and higher with Prior Covid, hybrid immunity, as seen in all studies Image
Read 8 tweets
Eric Topol Profile picture
Jan 21
Now there are 3 reports for vaccine effectiveness vs Omicron hospitalization, @UKHSA, @KPSCalResearch and today's @CDCMMWR. They are quite consistent for marked protection of the 3rd shot (booster). My summary table here
Here is today's @CDCMMWR report through January 5th on Omicron, key data summarized in the Table
cdc.gov/mmwr/volumes/7…
Here are the data from the new CDC report for vaccine effectiveness for both Delta and Omicron, 2-dose or 3-dose and vs Emergency Room visits or Hospitalizations
Read 5 tweets
Eric Topol Profile picture
Jan 18
It seems the people who write the vaccines w/ a booster aren't working against Omicron are completely out of touch with the data
I'd consider ~90% effectiveness vs hospitalization pretty, pretty damn good
assets.publishing.service.gov.uk/government/upl…
Especially compared with 44% without a booster
Then there's data for age 65+:
94% effectiveness, going to 89% after 10+ weeks
khub.net/documents/1359…
Maybe people will realize that we're very fortunate, given Omicron's extensive immune escape, to have this level of protection from an extra dose of a vaccine directed against a virus from 2 years ago
erictopol.substack.com/p/were-very-lu…
Read 4 tweets

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