Eric Topol Profile picture
Jan 31 5 tweets 3 min read
New @FT
"Almost half of the US Covid hospitalisations this winter could have been averted if the country had matched the vaccination coverage of leading European countries"
ft.com/content/03aa46… by @mroliverbarnes @jburnmurdoch @JamieSmythF
US lagging European peers by vaccine doses and boosters, especially notable in age 60+
"On December 20, 30% of people in the US over-65 had gone six months since receiving a second dose, compared with just 2% in Portugal; 5 per cent in England; and 7% in Denmark."
Graphic that shows differences in vaccination waning for US vs England, Denmark and Portugal, age 60+
Comments from @PeterHotez and me
A huge difference

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More from @EricTopol

Jan 28
Brief update on Omicron, and its BA.1 and BA.2 lineages (sisters)
1. Origin—the 3 theories for how this hyper-mutated version of the virus evolved
nature.com/articles/d4158… @nature
2. A great annotated graphic by @firefoxx66 of @nextstrain conveying the antigenic distance of Omicron's BA.1 and BA.2 from prior variants
nextstrain.org/ncov/gisaid/gl…
3. The BA.2 variant is spreading widely, throughout many countries in Europe and Asia, out-competing BA.1, indicating higher transmissibility. But the good news from yesterday's @UKHSA: vaccination + boost is holding up quite well; there's no indication of more immune evasion
Read 7 tweets
Jan 27
Important new @UKHSA report today sheds light on key Omicron concerns
assets.publishing.service.gov.uk/government/upl…
1. BA.2 Vaccine effectiveness holds up very well compared with BA.1 *with booster*
2. The vaccine effectiveness (VE) vs Omicron symptomatic infection vs Omicron falls off 15+ weeks, as was seen with the Israeli data, here more so with Pfizer compared to Moderna
3. But protection (VE) vs Omicron hospitalization remains quite high (Moderna > 90% thru 9 weeks)
Read 5 tweets
Jan 25
ICU admits may be the best proxy for lack of vaccinations. Israel and the US have low rates of vaccination (65, 63%) and have seen rising ICU rates in their Omicron waves (not seen in high vaxx % countries)
@OurWorldInData Image
Clarification: Colors are swapped on the vaccine right-sided panels. Israel has slightly more 2-shot vaccination and >2X boosters
Important graph from @StavKislev that supports my point Image
Read 4 tweets
Jan 24
How to reduce your chance of dying from Covid by 99%?
Get vaccinated and a booster.
One of the most impressive graphs I've seen for the impact of vaccination in the US pandemic
(thanks @redouad @OurWorldinData for re-plotting my makeshift graph from earlier today)
Highlighting the data above are for all ages
Graphs for vaccination vs deaths by age groups (w/o booster partitioned):
Now deaths by age groups: 65+, 50-49, 18-49
For each group, death is reduced by 99% for vaccination plus booster compared with unvaccinated (down to zero for youngest age group)
ourworldindata.org/grapher/united…
Read 5 tweets
Jan 23
What to make of Omicron's BA.1 and (sister) BA.2 lineages?
Both are hyper-mutated with over 50 mutations but many are different, particularly in the spike and ORF1a regions outbreak.info /1
There's not any functional or epidemiological data to show any meaningful differences....yet. But BA.2 has become dominant in Denmark, out-competing BA.1, and its prevalence is rising in India, Singapore, Sweden, the UK and other countries /2 Graph via @Mike_Honey_
The spread of BA.2 supports increased transmissibility (hard to imagine beyond BA.1, O's sister). On Jan 21st, UK designated it as a variant under investigation ft.com/content/34fef1… More to learn, keep 👀, no reason for distress at this point (we already have enough of that)
Read 4 tweets
Jan 22
Debunking the notion that boosters don't reduce Omicron symptomatic infections. Another new study from Qatar shows they are halved medrxiv.org/content/10.110… matched >400,000 people with mRNA vaccines 2 vs 3-dose Image
The booster reduction for Omicron symptomatic infections for 3-dose vs 2-dose was 66% in the @JAMA_current report yesterday
jamanetwork.com/journals/jama/… Image
Booster vaccine effectiveness vs Omicron infections 62% (2 dose 32%) @UKHSA in people without Prior Covid
assets.publishing.service.gov.uk/government/upl…
and higher with Prior Covid, hybrid immunity, as seen in all studies Image
Read 8 tweets

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