Tom Whipple Profile picture
Feb 15 18 tweets 6 min read
Just some more thoughts on this, because I don't think people realise quite how big our testing infrastructure has become - or how wide. 1/x
First, testing itself. Currently, we are PCR testing about 300,000 people a day, and recording over a million including lateral flows. This is us on a quiet day
Other countries have done more when pushed, but none do so at this level this consistently. But this is just the front end of our testing infrastructure.
It is blindingly obvious to anyone with GCSE level stats that you can't rely on self selected samples. We needed an opinion poll of covid - random testing.

It is so blindingly obvious that we have two systems to do this - ONS and Imperial's React.

Yet....
No other country does this. These surveys don't just tell us what is going on with infections now. They are solid data on transmission, reinfections etc.

This was the head of the German pandemic response's reference to it, and other things.
What other things? The next biggest is genomics. In March 2020 a bunch of geneticists met in London to consider what they could do. They thought it would be a good idea to sequence as much as possible. A lot of people thought that was silly.

thetimes.co.uk/article/genomi…
People continued to think it was silly through the summer, when Britain produced more genome sequences than the rest of the world combined - of this slowly-mutating virus that clearly wouldn't have concerning variants. Then Alpha happened.

Still, now, Britain sequences A LOT
It doesn't stop here. There is Siren, a study run by @SMHopkins . By regularly testing healthcare workers, who we know get infected more, PHE, then UKHSA, collected the most rapid data on vaccine protection and reinfections, among other things.

snapsurvey.phe.org.uk/siren/
There is Comix - regularly asking people about daily contacts. Again a bunch of scientists got together and just thought, what will we need in a pandemic, then they did it. This is week 98. They didn't expect 98 weeks. But we have 98 weeks of continuous, consistent data.
There is the vivaldi care home study - because we need good data on antibodies in the most vulnerable groups, in a pandemic that affects the most vulnerable ucl.ac.uk/health-informa…
There is the Icnaric intensive care audit - to see what happens to those worst affected.
There is wastewater sampling because everyone, except the queen, poos
There is loads more. A lot of this happened because some great scientists just took the initiative and did it.

Now the question is, what next for the UK's covid industrial complex? Some will be scrapped. Some will be repurposed.
Genomics has proven itself, and will be a key tool of public health.
The ONS knows it will have to slim down eventually, but many think it has a lot of value yet. It may get smaller and broader, looking at other diseases. Almost certainly the households involved will be followed for years to come, to see covid legacy. thetimes.co.uk/article/dont-d…
Along with clinical trials and the vaccines, it strikes me that covid surveillance is something that has been done very well, and doesn't get enough recognition. Did it make a difference to our pandemic? No idea. But the world has been grateful.
Addendum - as a few have rightly pointed out, the UK standard self-selected testing is high, but not the highest. I shouldn't have put that in without checking properly (it's not in the piece itself).

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Tom Whipple

Tom Whipple Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @whippletom

Feb 3
I'm going through this paper by Johns Hopkins economists, that assesses the efficacy of lockdown in the US and Europe - and concludes it was essentially useless.

I'd love thoughts on something I've found, which may well be my misinterpretation 1/x sites.krieger.jhu.edu/iae/files/2022…
The study is a meta-analysis, combining other previous between-country comparisons. To produce the combined estimate, they take 18,000 studies, exclude all but a handful and then pool their findings. Image
Looking at the weighting, it actually seems to be based almost entirely on one study. So rather than being a meta-analysis it is really a recapitulation of that study, by Chisadza et al Image
Read 11 tweets
Dec 8, 2021
Briefing on Pfizer/biontech neutralisation studies has begun. 19 or 20 seras (why don't they know which?!)

1/x
Stark - v stark - difference between two and three doses. Three looks almost as good.
Is this analagous to delta? It escaped one dose, but was pinned down with two. Omicron escapes two, but cornered by three.
Read 11 tweets
Nov 26, 2021
For people who talk about boys crying wolf...actually the boy has been pretty restrained regarding variants. Remember iota or kappa?

This one is different

thetimes.co.uk/article/b30489…
Those other variants in full:

1. Alpha, the Kent variant. In November of 2020, amid a national lockdown, cases started rising in Sheppey. Everyone thought it was just people in Sheppey doing Sheppey things. Turned out it wasn't. It was a 50 per cent more transmissible variant
(here is the definitive report:reuters.com/investigates/s…)

Verdict: scariant
Read 11 tweets
Jul 26, 2021
And on this edifying note, I'm signing out of twitter. I'm off on much-delayed paternity leave. I was meant to do it last year, but decided to delay until the pandemic was over. Not tweeting until the autumn.

In the meantime, everyone is cross. Here is covid stuff that's great:
The covid dashboard, coronavurus.data.gov.uk, by @Pouriaaa and @statsgeekclare and doubtless loads of others. Clear, invaluable and does exactly what it should.
The variant technical group, with @meera_chand , @jcbarret, @PHE_uk and others. Absolutely stunning. Basically mathematical witchcraft, calculating all the crucial efficacy and transmissibility data on the fly, amid massive uncertainty google.com/url?sa=t&sourc…
Read 13 tweets
Feb 7, 2021
Demographics of the South African study into Oxford vaccine
Criteria for mild or moderate cases
Neutralization data - immune responses "similar if not better"
Read 14 tweets
Feb 5, 2021
Sage has released its reasonable worst case scenarios for winter resurgence, as envisaged in July. Looks like we are teetering towards the unreasonable worst case scenarios...
They were especially worried about: schools and universities, importation from holidays abroad
One key recommendation for mitigating it: better support for those isolating
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

:(