Eric Topol Profile picture
Feb 18 5 tweets 3 min read
New @CDCgov
Proof of benefit of vaccine booster for protection from Covid hospitalization in young, age 18-49, as previously documented in other countries
covid.cdc.gov/covid-data-tra…
77% reduction with 2-shots
94% reduction with booster Image
All ages, 18+
2-shot reduction of hospitalization 76%
3-shot reduction of hospitalization 93% Image
Remarkable consistency across age groups for reduction of hospitalization for 2-shot and booster vaccination vs unvaccinated
2-shot 3-shot
Age 18-49 77% 94%
Age 50-64 79% 92%
Age 65+ 74% 94% Image
The never ending bias of reporting that people age 18-49 lack benefit of booster shots vs Covid hospitalization: the relative benefit the same in all age groups; absolute benefit per 100,000 people is substantial
nytimes.com/2022/02/20/hea…
+ @CDCgov had the data, didn't publish it Image
That the protective benefit would be proportionately the same in young people as old was fully anticipated (and previously documented in other countries). Here's the fallacious reasoning explained
erictopol.substack.com/p/how-to-misin…

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More from @EricTopol

Feb 20
My new essay @guardian
"Why one-shot after a Covid-19 infection should suffice to be considered fully-vaxxed"
theguardian.com/commentisfree/…
Summarizes extensive new evidence that confirmed Prior Covid ("Natural Immunity" or NI) + 1-shot is as protective as 3-shots /1
These 6 new reports (5 in the last week) all demonstrate that NI + 1-shot provides a consistent high level of added protection from reinfection, across multiple variants, which is not ameliorated by additional shots /2
I've reviewed considerable other new data here, such as the J&J vaccine randomized, placebo-controlled trial report last wk @NEJM which showed NI had superior protection vs moderate-to-severe Covid than 1-shot of the vaccine (90% vs 56%, respectively)
erictopol.substack.com/p/ground-truth… /3
Read 5 tweets
Feb 13
We've learned a lot about Prior Covid ("Natural Immunity") over the past year, but the US/CDC continues to negate the abundant evidence for it providing any protection
erictopol.substack.com/p/ground-truth… w/links
And there's substantial new data, I'll review🧵here /1
Last week, the large J&J 1- shot, placebo-controlled trial w/ >2,000 participants who had Prior Covid published @NEJM
Vaccine effectiveness vs moderate/severe disease
Prior Covid 90%
J&J Vaccine 56%
Yet 1-shot J&J vaccine = "fully vaccinated" @CDCgov
Nothing for Prior Covid /2
Neutralizing antibodies after Prior Covid are present out to 16 months in 214 people (graph)
And another study showing persistence of memory B cells at 15 months /3
Read 13 tweets
Feb 9
Today >3,400 Covid deaths reported in the United States, a 7-day average exceeding 2,600 lost lives.
This likely represents the current wave peak; 80% of the US pandemic peak when there were no vaccines. Compared to 20% in countries with high % vaccination and booster rates Image
OTOH at least we're seeing a rapid descent of hospitalizations to the 100,000 level Image
Read 4 tweets
Feb 7
🆕 Omicron [O] and Delta [D] outcomes for hospitalizations, deaths and by vaccines in > 1 million O and ~450,000 D cases in England
papers.ssrn.com/sol3/papers.cf…
—75% reduced hospitalization risk for O vs D
—For O, Booster >70% protection vs hospitalizations and deaths across all ages
2 and 3 dose vaccine effects vs hospitalization (both AZ and mRNA)
and
Prior Covid, without vaccination, had moderate protection (HR 0.53) vs hospitalization for Omicron, and high protection vs death.
Children age < 10 had infrequent hospital admissions and the incidence did not differ significantly between Delta and Omicron
Read 4 tweets
Feb 4
New: Assessment of an Omicron-specific booster vs Moderna original (vs ancestral) booster in macaques: no difference
"An Omicron boost may not provide greater immunity or protection compared to a boost with the current mRNA-1273 vaccine"
biorxiv.org/content/10.110… Image
Interesting to note that the same was seen for the Beta variant with the Pfizer vaccine, original vaccine booster vs Beta-specific booster, which led to abandoning that strategy.
3rd shots of the original vaccines are performing far better than expected 👍
A very good thread on the new Omicron-specific booster study and the overarching issue by @erlichya
Read 4 tweets
Feb 4
New @CDCgov
Reduction of death by vaccination and booster by age, per 100,00 people, vs unvaccinated, relative, with absolute data below
covid.cdc.gov/covid-data-tra…
Age 65+
2 shot 92% reduced
3 shot 99% reduced
Age 50-64
2 shot 95% reduced
3 shot 99% reduced
By age: cases and vaccination/booster status
As cases were rising steeply in December with emergence of Omicron, booster vs 2-shot was associated with 50% or more reduction of cases across the 3 age groups
And much higher % drop for vaccination vs unvaccinated
Which goes along with this new data posted showing booster had vaccine effectiveness of >60% vs Omicron infections
covid.cdc.gov/covid-data-tra…
Read 5 tweets

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