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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
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Feb 26 β€’ 9 tweets β€’ 9 min read
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

πŸ‘‰ kdigo.org/wp-content/upl…
Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Mitigation strategies vs side effects of SGLT2inhibitors and GLP-1 Receptor agonists
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
More on SGLT2 inhibitors:
πŸ“Œ Expanded indications
πŸ“Œ Initiation
πŸ“Œ Dosing recommendations
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
FIDELITY: Both CV and kidney benefits were consistent irrespective of SGLT-2i use at baseline

FIDELIO-DKD nejm.org/doi/full/10.10…
FIGARO-DKD nejm.org/doi/full/10.10…
FIDELITY academic.oup.com/eurheartj/arti…

#VisualAbstract by @whatsthegfr
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
DE BOER: New recommendation for non-steroidal MRA
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Potassium management with Finerenone
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
CHAN: Dietary management in patients with T2D and CKD - 10 Tips to cut salt πŸ§‚
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

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More from @edgarvlermamd

Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Feb 26
.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

πŸ‘‰ kdigo.org/wp-content/upl…
IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

πŸ“Œ A GFR of 30 is considered a threshold for treatment

#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Read 13 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Feb 23
First clinical-grade porcine πŸ– kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

πŸ‘‰πŸΌ pubmed.ncbi.nlm.nih.gov/35049121/ Image
Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10… ImageImage
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 30
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 26
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Read 5 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

πŸ‘‰ global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Nov 5, 2021
Mineralocorticoid receptor (MR) has a role in:
πŸ‘‰ BP regulation
πŸ‘‰ Electrolyte Homeostasis

Overactivation of MR leads to:
πŸ‘‰ Inflammation and Fibrosis
πŸ‘‰ Sodium retention

#KidneyWk #Nephpearls #Cardiorenal ImageImage
Finerenone: potent and selective non-steroidal MR antagonist (MRA) that is distinct from steroidal MRAs

#KidneyWk #Nephpearls #Cardiorenal ImageImage
FIDELITY pre-specified pooled analysis
πŸ‘‰ FIDELIO-DKD
πŸ‘‰ FIGARO-DKD
#KidneyWk #Nephpearls #Cardiorenal ImageImageImageImage
Read 4 tweets

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