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Edgar V. Lerma 🇵🇭 Profile picture
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Jan 26 • 5 tweets • 9 min read
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Nice slide by @ArchanaVajjala summarizing the studies on dosing regimen of steroids for relapses in Steroid-sensitive Nephrotic Syndrome #NephJC #IPNAJC #Nephpearls
Treatment of MCD in children:
📌 Glucocorticoid-sparing therapies in children with Steroid Sensitive Nephrotic Syndrome (SSNS)
📌 Treatment of Steroid Resistant Nephrotic Syndrome (SRNS) in children

ca. 2021 from @goKDIGO #NephJC #IPNAJC #Nephpearls

👉 kdigo.org/wp-content/upl…

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More from @edgarvlermamd

Edgar V. Lerma 🇵🇭 Profile picture
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

👉 global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Nov 5, 2021
Mineralocorticoid receptor (MR) has a role in:
👉 BP regulation
👉 Electrolyte Homeostasis

Overactivation of MR leads to:
👉 Inflammation and Fibrosis
👉 Sodium retention

#KidneyWk #Nephpearls #Cardiorenal ImageImage
Finerenone: potent and selective non-steroidal MR antagonist (MRA) that is distinct from steroidal MRAs

#KidneyWk #Nephpearls #Cardiorenal ImageImage
FIDELITY pre-specified pooled analysis
👉 FIDELIO-DKD
👉 FIGARO-DKD
#KidneyWk #Nephpearls #Cardiorenal ImageImageImageImage
Read 4 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Oct 13, 2021
New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race ca. 2021 from @NEJM #NephJC #Nephpearls
#VisualAbstract by @MdYoshinosuke

nejm.org/doi/full/10.10… ImageImage
A Unifying Approach for GFR Estimation: Recommendations of the @nkf @ASNKidney Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease ca. 2021 from @JASN_News #NephJC #Nephpearls

jasn.asnjournals.org/content/early/… ImageImage
Nice table comparing the different equations used to estimate kidney function #NephJC #Nephpearls
Credit: @michaelturk6 and @nefron1310 Image
Read 5 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Sep 12, 2021
On the road again

Chapter 5: Functions of the Distal Nephron #Nephpearls

🎙 rosebook.club
Gitelman syndrome: diagnostic criteria #Nephpearls
👉🏼 pubmed.ncbi.nlm.nih.gov/28003083/
Whenever I hear Gitelman and Gordon in one sentence, I remember this nice table from @RenalFellowNtwk @docpro89 #Nephpearls

👉🏼 renalfellow.org/2018/11/19/raa…
Read 6 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Jun 23, 2021
Efficacy and safety of voclosporin versus placebo for #lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial from @TheLancet @BradRovin #NephJC #Nephpearls
#VisualAbstract by @katierizzolo
👉🏼 thelancet.com/journals/lance…
Voclosporin: Hope on the Horizon for #Lupus Nephritis ⁉️ from @KidneyNews February 2021 issue #Nephpearls #NephJC
👉 asn-online.org/publications/k…
AURA-LV: A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis ca. 2018 from @Kidney_Int @BradRovin #Nephpearls #NephJC
👉🏼 kidney-international.org/article/S0085-…
Read 6 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Jun 17, 2021
Happening now‼️
@NKFIllinois Controversies in #Nephrology #Nephpearls Image
Balanced crystalloids vs saline in critically ill & non-critically ill adult patients from @NEJM #Nephpearls
#VisualAbstract by @aakashshingada
👉🏼 SALT-ED pubmed.ncbi.nlm.nih.gov/29485926/
👉🏼 SMART pubmed.ncbi.nlm.nih.gov/29485925/ ImageImageImage
Urgent-start PD is defined as initiation of PD in patients w/ newly diagnosed ESKD who are not yet on dialysis and who require dialysis initiation < 2 weeks (as little as 24-48 hours) after PD catheter placement but do not require emergent dialysis #Nephpearls Image
Read 5 tweets

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