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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
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Feb 23 β€’ 4 tweets β€’ 6 min read
First clinical-grade porcine πŸ– kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

πŸ‘‰πŸΌ pubmed.ncbi.nlm.nih.gov/35049121/ Image
Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10… ImageImage
The 10-gene pig and other medical science advances enabled UAB’s transplant of a pig kidney into a brain-dead human recipient #NephJC #Nephpearls

πŸ‘‰ uab.edu/news/research/… ImageImageImage

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More from @edgarvlermamd

Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 30
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 26
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Read 5 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

πŸ‘‰ global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Nov 5, 2021
Mineralocorticoid receptor (MR) has a role in:
πŸ‘‰ BP regulation
πŸ‘‰ Electrolyte Homeostasis

Overactivation of MR leads to:
πŸ‘‰ Inflammation and Fibrosis
πŸ‘‰ Sodium retention

#KidneyWk #Nephpearls #Cardiorenal ImageImage
Finerenone: potent and selective non-steroidal MR antagonist (MRA) that is distinct from steroidal MRAs

#KidneyWk #Nephpearls #Cardiorenal ImageImage
FIDELITY pre-specified pooled analysis
πŸ‘‰ FIDELIO-DKD
πŸ‘‰ FIGARO-DKD
#KidneyWk #Nephpearls #Cardiorenal ImageImageImageImage
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Oct 13, 2021
New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race ca. 2021 from @NEJM #NephJC #Nephpearls
#VisualAbstract by @MdYoshinosuke

nejm.org/doi/full/10.10… ImageImage
A Unifying Approach for GFR Estimation: Recommendations of the @nkf @ASNKidney Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease ca. 2021 from @JASN_News #NephJC #Nephpearls

jasn.asnjournals.org/content/early/… ImageImage
Nice table comparing the different equations used to estimate kidney function #NephJC #Nephpearls
Credit: @michaelturk6 and @nefron1310 Image
Read 5 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Sep 12, 2021
On the road again

Chapter 5: Functions of the Distal Nephron #Nephpearls

πŸŽ™ rosebook.club
Gitelman syndrome: diagnostic criteria #Nephpearls
πŸ‘‰πŸΌ pubmed.ncbi.nlm.nih.gov/28003083/
Whenever I hear Gitelman and Gordon in one sentence, I remember this nice table from @RenalFellowNtwk @docpro89 #Nephpearls

πŸ‘‰πŸΌ renalfellow.org/2018/11/19/raa…
Read 6 tweets

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