💥 Two pre-prints just dropped that clarify the origin & emergence of SARS-CoV-2. The first makes the case that lineages A & B represent independent spillovers from animals.. work by @jepekar @MichaelWorobey @K_G_Andersen @edwardcholmes & more 🧵 zenodo.org/record/6291628
The second one further substantiates that the Huanan “seafood market” in central Wuhan was where these spillover events occurred. It’s by @MichaelWorobey @stgoldst @angie_rasmussen @arambaut @K_G_Andersen @robertson_lab @acritschristoph @MarionKoopmans zenodo.org/record/6299116
Adding to the case that the Huanan Seafood Market was initial site of spillover, another preprint just dropped— this one led by George Gao of the China CDC. Their work independently reached the same conclusion. researchsquare.com/article/rs-137…
Weird, it’s almost as if people have been investigating the origin of #SARSCoV2! Overall, not good day for the so-called “lab leak” hypothesis.
Frankly, apart from (1) “but, but, …they had a virology lab in Wuhan that studied these viruses” & (2) “China won’t cooperate, it must be cover up” …there hasn’t been a shred of solid evidence to support the case for a laboratory origin in the first place.
Probably the most compelling #tweetorial I’ve ever read.. Dr. Worobey breaks this all down in stunningly lucid detail #Scitwitter cc: @EricTopol @carlzimmer 👇

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More from @macroliter

Feb 3
USA & Western Europe’s insistence on Public Domain sharing of pathogen genome 🧬 data harms our ability to track viral evolution in real time & to suss out origins of SARS-CoV-2. Incentives matter! #EquitableGenomicSurveillance 🧵
I believe that NCBI /INSDC are critically important resources. But they aren’t built for equitable data sharing. The little people are asked to rapidly share their data via public domain while for profit corporations get to mine these data & sell insights to others in market.
Our failure to build an equitable marketplace for these 🦠 🧬 data threatens us all during epidemics & between them.. it makes us all poorer. It’s a business problem that’s inextricable from lots of inequities in realms of health, big data & international benefit sharing.
Read 6 tweets
Jan 28
Yes.. BA.2 is increasing in USA.. but total is still only 180 entries in GISAID from all of USA, while BA.1 is at 132,497..
If we filter to only samples collected since Jan 10, it's: 127 BA.2 in USA versus 16,407 BA.1
If BA.2 takes over as % of new U.S. cases, as seems plausible, this will happen much more slowly than Omicron displacing Delta... Not maybe as slow as AY4.2 (LOL!) but I'd guess it'll take at least another month.. & will coincide w/ overall waning of the Omicron (BA.1+BA.2) wave
Keep in mind that although BA.1 and BA.2 might compete with each other, BA.2 didn’t evolve / emerge to escape anti-BA.1 antibodies..
Read 11 tweets
Jan 28
Sad to learn that Dr. Mia Brytting has died. She contributed hugely to surveillance of RNA viruses: IAV, RSV, echovirus, norovirus, SARSCoV2, etc, studying their epidemiology & evolution & evaluating real-world vaccine efficacy. An incalculable loss! 😢scholar.google.com/scholar?hl=en&…
So much important work ... eurosurveillance.org/content/10.280…
Read 4 tweets
Jan 27
"Learning immunology without the pathogen is like watching a football match without seeing the ball-- you're just seeing players run around and have no idea what's going on.. you'd probably think they are just going mad.." - @askia_tm... 1/5 🧵
.. @askia_tm is a phenomenally intelligent young viral immunologist from Liberia.. He's now studying virology in West Java, Indonesia. The guy is not only smart at science, but is also a blossoming advocate for global public health & for decentralizing competence.. 2/5
He worked with the "Ebola awareness team" during the response to 2014-15 outbreak in Liberia. He understands the importance being able to reach communities in their own language, and was surprised how few Liberian scientists were publishing on Ebola from that outbreak and.. 3/5
Read 5 tweets
Jan 27
SARSCoV2 trajectory toward #Omicron is AFAIK 1st 🥇 example of science watching trajectory of viral evolution to fulfill #CanyonHypothesis (more closed entry protein that hides receptor binding domain from antibodies). Beginning of pandemic was opposite: S became more “open” 👇👇
The #CanyonHypothesis was first put forth by the late Michael G Rossmann, a prominent viral structural biologist who died in May 2019. Anyone interested in SARS-CoV-2 Spike evolution should read the paper. Nothing short of prophetic pubmed.ncbi.nlm.nih.gov/2670920/
Read 5 tweets
Jan 22
“Mr. Moreau caught the coronavirus during its second wave in 2020 & suffered a stroke while working at his desk. A friend of his died just last weekend. But vaccination has plateaued at 39%, ~24 percentage points lower than the U.S. over all” #VaccinesWork theglobeandmail.com/world/us-polit…
“It is places such as East Feliciana that are increasingly suffering the consequences. The parish has seen 154 deaths in a population of 19,500, a per-capita rate more than double those of Los Angeles & Chicago, and triple that of New Orleans.”
“Out of the 100 U.S. counties with the highest death rates, 95 have populations of fewer than 100,000 people. None contain major cities.”
Read 4 tweets

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