✳️ #TenTweetNephJC ✳️
Did you see in the news that they’ve transplanted a pig kidney into a human and it (sort of) worked?
That was the #NephJC chat last week - for a rapid summary check out the thread👇
Did you see in the news that they’ve transplanted a pig kidney into a human and it (sort of) worked?
That was the #NephJC chat last week - for a rapid summary check out the thread👇
What did I miss?
We need more kidneys to transplant, hence the University of Alabama is running xenotransplant research.
Porcine kidney transplantation into humans has been tried before, but this is the first study to report no hyperacute rejection.
pubmed.ncbi.nlm.nih.gov/35049121/
We need more kidneys to transplant, hence the University of Alabama is running xenotransplant research.
Porcine kidney transplantation into humans has been tried before, but this is the first study to report no hyperacute rejection.
pubmed.ncbi.nlm.nih.gov/35049121/
1 tweet methods
✅Family of a 57 y.o. man with brain death gave consent
✅Pig with 6 human genes knocked in & 4 pig genes knocked out
✅Negative crossmatch
✅Descendant underwent induction immunosuppression, bilateral native nephrectomy, & implantation of two porcine kidneys
✅Family of a 57 y.o. man with brain death gave consent
✅Pig with 6 human genes knocked in & 4 pig genes knocked out
✅Negative crossmatch
✅Descendant underwent induction immunosuppression, bilateral native nephrectomy, & implantation of two porcine kidneys
1 tweet results
🔹3 days of observation = one kidney made decent urine volumes, but serum creatinine didn’t fall
🔹There was no hyperacute rejection, no life-threatening complications, & no evidence of infection transmission
🔹TMA & tubular injury present on post-op biopsies
🔹3 days of observation = one kidney made decent urine volumes, but serum creatinine didn’t fall
🔹There was no hyperacute rejection, no life-threatening complications, & no evidence of infection transmission
🔹TMA & tubular injury present on post-op biopsies
A figure paints 1000 words
Give me something clever to say
“The key has been identifying major antigens like GAL in pigs, which we already have pre-formed natural antibodies against. Now with CRISPR deletion of GAL antigen is possible, extending the life of the xenograft”
“The key has been identifying major antigens like GAL in pigs, which we already have pre-formed natural antibodies against. Now with CRISPR deletion of GAL antigen is possible, extending the life of the xenograft”
Chat consensus?
1️⃣ Don’t under-estimate the importance of genetic engineering overcoming the species barrier
2️⃣ Making any urine in less than ideal circumstances is still impressive
3️⃣ There’s a long way to go but this is exciting, and is worthy of substantial investment
1️⃣ Don’t under-estimate the importance of genetic engineering overcoming the species barrier
2️⃣ Making any urine in less than ideal circumstances is still impressive
3️⃣ There’s a long way to go but this is exciting, and is worthy of substantial investment
Quote of the fortnight!
@anuja_java describing a common emotion among transplant teams worldwide, and you should read @hswapnil’s reply……
@anuja_java describing a common emotion among transplant teams worldwide, and you should read @hswapnil’s reply……
https://twitter.com/anuja_java/status/1496318590169014275?s=20&t=KaoC8uBw9b-yhOSBNaCG8g
I want more info
✅ Read this summary from @nephromythri @NamrataYParikh
nephjc.com/news/xenotrans…
✅ Check out the VA by @NamrataYParikh
✅ Read this summary from @nephromythri @NamrataYParikh
nephjc.com/news/xenotrans…
✅ Check out the VA by @NamrataYParikh
Up next:
Some bad news from the PATH-BP trial - does acetaminophen cause hypertension? See you on 8/9 March!
Link - pubmed.ncbi.nlm.nih.gov/35130054/
(before you ask, yes 4g/day is the standard dose in UK, & no we don’t see liver failure from it!)
Tweetorial from @jamiekwillows
Some bad news from the PATH-BP trial - does acetaminophen cause hypertension? See you on 8/9 March!
Link - pubmed.ncbi.nlm.nih.gov/35130054/
(before you ask, yes 4g/day is the standard dose in UK, & no we don’t see liver failure from it!)
Tweetorial from @jamiekwillows
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