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Eric Topol Profile picture
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Mar 10 • 4 tweets • 2 min read
US Covid hospitalizations descend to their lowest level in over 8 months, and below all but 1 of its pandemic waves👍
It doesn't mean we're out of the woods.
Keep in mind that in England hospital admissions have started to rise again
ft.com/content/e26c93…
Possible explanations and implication, @chrischirp
New data, favorable insight

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More from @EricTopol

Eric Topol Profile picture
Mar 7
Just published @nature
The impact of #Covid on the brain: the 1st longitudinal imaging study before and after infection, with controls
nature.com/articles/s4158…
Reduction of grey matter, brain size, cognitive decline
Demographics of Covid cases and controls. Only 15 of cases were hospitalized and results did not change when they were deleted from analysis
One of the most important studies of the pandemic; further work to determine reversibility needed. Credit @OxfordWIN @uk_biobank Gwenaelle Douaud and colleagues for this contribution
Read 4 tweets
Eric Topol Profile picture
Mar 5
4 Asian-Pacific countries have experienced severe Omicron waves, but only 1 has an extremely high death toll. Why? /1
@OurWorldInData
There's a marked difference in vaccination and boosters /2
This is especially the case for the elderly /3
ft.com/content/2fc339… by @ThomasHHChan @primroseriordan @imandylin2 @FT
Read 7 tweets
Eric Topol Profile picture
Feb 20
My new essay @guardian
"Why one-shot after a Covid-19 infection should suffice to be considered fully-vaxxed"
theguardian.com/commentisfree/…
Summarizes extensive new evidence that confirmed Prior Covid ("Natural Immunity" or NI) + 1-shot is as protective as 3-shots /1
These 6 new reports (5 in the last week) all demonstrate that NI + 1-shot provides a consistent high level of added protection from reinfection, across multiple variants, which is not ameliorated by additional shots /2
I've reviewed considerable other new data here, such as the J&J vaccine randomized, placebo-controlled trial report last wk @NEJM which showed NI had superior protection vs moderate-to-severe Covid than 1-shot of the vaccine (90% vs 56%, respectively)
erictopol.substack.com/p/ground-truth… /3
Read 5 tweets
Eric Topol Profile picture
Feb 18
New @CDCgov
Proof of benefit of vaccine booster for protection from Covid hospitalization in young, age 18-49, as previously documented in other countries
covid.cdc.gov/covid-data-tra…
77% reduction with 2-shots
94% reduction with booster Image
All ages, 18+
2-shot reduction of hospitalization 76%
3-shot reduction of hospitalization 93% Image
Remarkable consistency across age groups for reduction of hospitalization for 2-shot and booster vaccination vs unvaccinated
2-shot 3-shot
Age 18-49 77% 94%
Age 50-64 79% 92%
Age 65+ 74% 94% Image
Read 5 tweets
Eric Topol Profile picture
Feb 13
We've learned a lot about Prior Covid ("Natural Immunity") over the past year, but the US/CDC continues to negate the abundant evidence for it providing any protection
erictopol.substack.com/p/ground-truth… w/links
And there's substantial new data, I'll review🧵here /1
Last week, the large J&J 1- shot, placebo-controlled trial w/ >2,000 participants who had Prior Covid published @NEJM
Vaccine effectiveness vs moderate/severe disease
Prior Covid 90%
J&J Vaccine 56%
Yet 1-shot J&J vaccine = "fully vaccinated" @CDCgov
Nothing for Prior Covid /2
Neutralizing antibodies after Prior Covid are present out to 16 months in 214 people (graph)
And another study showing persistence of memory B cells at 15 months /3
Read 13 tweets
Eric Topol Profile picture
Feb 9
Today >3,400 Covid deaths reported in the United States, a 7-day average exceeding 2,600 lost lives.
This likely represents the current wave peak; 80% of the US pandemic peak when there were no vaccines. Compared to 20% in countries with high % vaccination and booster rates Image
OTOH at least we're seeing a rapid descent of hospitalizations to the 100,000 level Image
washingtonpost.com/health/2022/02… by @FenitN @dtkeating
Read 4 tweets

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