#LongCovidKids in Italy || Starting from the key clinical experience of a post covid clinic in Rome

@surf4children et al

"Long-term outcomes of pediatric infections: from traditional infectious diseases to #LongCovid" | Future Microbiology
futuremedicine.com/doi/10.2217/fm…
#LongCovidKids in New Zealand 🇳🇿
A blog review of prolonged disease and sequelae in children after SARS-CoV-2 infection || including Long Covid and MIS-C || literature review and risk assessment with omicron

@DrAnnaNZ et al

@LongCovidNZ

blogs.otago.ac.nz/pubhealthexper…
Persistent lung dysfunction in children after SARS-CoV-2 infection

Even children are at risk of pulmonary sequelae from covid, despite this risk being downplayed since the early pandemic

#LongCovidKids

[pre-print]

medrxiv.org/content/10.110…
We need to appropriately report on #LongCovid in children: the risk is certainly not negligible! Many symptom-based studies risk to under-count and underestimate the numbers

#LongCovidKids

@TheLancet

@dgurdasani1 @AthenaAkrami
et al.

thelancet.com/journals/lanch…
"Children with Long Covid" by H. Thomson

Severe evidence is emerging that pediatric patients are affected by prolonged disease after SARS-CoV-2 infection

#LongCovid #LongCovidKids

with mention of advocacy and patient-led resources by @LongCovidKids

ncbi.nlm.nih.gov/pmc/articles/P…
There is urgent need to address the risk and treatment of #LongCovid in children: growing research shows kids can develop prolonged symptoms and sequelae after SARS-CoV-2 infection

Editorial in the key scientific journal @Nature out in early 2022

nature.com/articles/d4158…
Children and young people can experience persistent symptoms after SARS-CoV-2 infection, as reported by the patient community

Why we need to keep using the patient-made term #LongCovid

Myself and co-authors in @bmj_latest on 1 October 2020

blogs.bmj.com/bmj/2020/10/01…
Children can experience persistent covid symptoms, although this remained poorly investigated as of late summer 2020. Yet, patient-led research and reports e.g. from @LongCovidKids clearly showed #LongCovidKids was a thing

Out on 2/09/2020

undark.org/2020/09/02/kid…
Reports and advocacy by parents and children with #LongCovid were crucial to draw attention to #LongCovidKids in 2020

Early patient reports are being confirmed by new, key scientific evidence

Myself and @felicitycallard pre-print out in early 2021

osf.io/preprints/soca…
New research into the immune profile of MIS-C, with evidence of severe dysregulation

MIS-C is the multi-system inflammatory sindrome seen in children a few weeks after SARS-CoV-2 infection. It can be fatal

#LongCovidKids

h/t @CovidSolidarit1

jacionline.org/article/S0091-…
A small case series from early 2020 || children with critical covid, who required ECMO = Extracorporeal Membrane Oxygenation

Thankfully rare

Note that at least 1 child suffered pulmonary embolism 30 days into care > prolonged coagulopathy

journals.lww.com/asaiojournal/F…
Large meta-analysis of existing studies suggests #LongCovidKids is not rare | multiple symptoms ~ clinical signs identified, many of which overlap with those in adults | pre-print | limitation: study based on review of previous research

h/t @BinitaKane

medrxiv.org/content/10.110…
Myocardial involvement in a small sample of children from Italy's early wave in 2020. Some little patients report multi-system symptoms, later known as #MISC

#LongCovidKids

ncbi.nlm.nih.gov/pmc/articles/P…
Clinical characteristics of a sample of children suffering from pediatric #LongCovid

@surf4children et al. (2022) incl. @LongCovidKids

#LongCovidKids

futuremedicine.com/doi/10.2217/fm…

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More from @elisaperego78

Apr 2
Great thread about the current wave. People are less likely to go into respiratory failure --either because of vaccination | prior immunity or omicron intrinsic features -- or both
But covid is not a respiratory disease only. It's multi-system, with huge cardiovascular potential
Covid can affect all organs and body systems. It can present with prolonged symptoms and sequelae #LongCovid
This is not uncommon. It can be potentially with lifelong consequences. Even in the vaccinated and in those with mild or asymptomatic disease at onset
We obviously all hope vaccination will hold strong. The reduction in mortality and severe disease is important. But significant long-term effects and symptomatic disease are well documented in post-vaccination infections, too
We need to cut transmission. Period.
Read 4 tweets
Apr 2
Ah this is an excellent point by @ErinSandersNP | clinical trials
We've been on an unrelanted SARS-CoV-2 spread for 2 years: a new, dangerous, highly contagious pathogen. Almost all world risk infection
We won't have "clean" dataset even for studying other diseases anymore

🧵
Biomedical research risks taking a huge hit from unleashed SARS-CoV-2 spread. "Historical" (i.e. pre pandemic) datasets will be useful to an extent. But as the time goes by, and new research is needed, SARS-CoV-2 infection | #LongCovid etc. risk to be huge confounding factors
I simplify a lot. Just a little example. Let's say you want to study autoimmune diseases like reumathoid arthritis or lupus (SLE). We know covid | SARS-CoV-2 infection have been linked to autoimmune phenomena. Many covid patients don't even have proven evidence of infection
Read 8 tweets
Apr 1
Congratulations to @LongCovidKids
and allies for being at Downing Street today and raise awareness of #LongCovid in children and young people 🔥
Proud and committed as usual to support recognition of, and research, into #LongCovidKids

express.co.uk/news/science/1…
There are an estimated ~119.000 children and young people to have experienced #LongCovid in the UK alone. Around 21.000 have been ill for over 1 year. The real numbers could be even higher: some children might be living with subclinical ("silent") pathology or undiagnosed disease
We don't even know about the longest-term effects of SARS-CoV-2 infection in the years/decades to come. Data from other viral infections are sobering: we know viruses are associated, or suspected to be associated, with a wide range of conditions emerging much later from infection
Read 10 tweets
Apr 1
It is critical to recognize covid | SARS-CoV-2 infection | #LongCovid do affect children and young people. We have known this since 2020. Advocacy and patient-led research has been crucial to the recognition of #LongCovidKids since the early pandemic days 💙
We have now a wealth of fresh, growing scientific evidence on #LongCovidKids. This is also from patient-led research and expertise.
It is critical policy makers and medical professionals are fully updated on, and open to address SARS-CoV-2 infection's sequelae
Wonderful to see @LongCovidKids new support guide freely available to families, patients, policy makers and medical professionals 🔥
Testimonials from young people with #LongCovid have been truly instrumental to shed a light on the disease. My gratitude

#LongCovidKids
Read 4 tweets
Mar 31
Covid | diabetes | #LongCovid

An easy-to-read, short report in top @Nature about Yan Xie and @zalaly recent @TheLancetEndo study.

The study found an increase in diabetes and antihyperglicaemic use within around 1 year post-covid, in survivors.
"Post-acute COVID-19 care should involve identification and management of diabetes"

#LongCovid

thelancet.com/journals/landi…
The @TheLancetEndo study makes use of a 181.280 people-strong cohort of covid patients. It compares their data with a massive pre-pandemic control group (no covid possible!) and a very large control group of contemporary people never diagnosed with covid
Read 4 tweets
Mar 31
Per gli amici e i pazienti italiani, da domani @LongCovidKids offre un'aggiornata guida scaricabile sul Long Covid pediatrico, pensata per essere accessibile anche alle famiglie e ai giovani malati.

#LongCovid #LongCovidKids
Troverete testimonianze di vita dei giovani pazienti, potenziali meccanismi del #LongCovid pediatrico, patologie connesse, come sindromi post-virali note, e informazioni su prospettive di cura, ricerca, management dei sintomi, e supporto
Troverete la storia di #LongCovid e #LongCovidKids come patologie alla cui identificazione e definizione, i pazienti stessi, con un enorme lavoro di documentazione e advocacy, hanno dato un contributo decisivo a partire dal 2020 Riconoscimento da OMS nello stesso anno
Read 6 tweets

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