Wow. guys in my publications (2020 and 2022) I say Tn depletion would cause some worse reinfections
NOT cause opportunistic disease
Don't put words in my mouth
The only person I saw who said opportunistic infections was Brian
NOT cause opportunistic disease
Don't put words in my mouth
The only person I saw who said opportunistic infections was Brian
https://twitter.com/fitterhappierAJ/status/1503746974876590087
from 2020. More severe reinfections from a contraction of the Naive T cell population. 
However, unpublished, I have suggested that harm to the CD8 repertoire could mean people were worse at fighting EBV, HPV, and some immunogenic cancers.
Those are NOT opportunistic infections
https://twitter.com/fitterhappierAJ/status/1292971658052018177
Those are NOT opportunistic infections
You've got to get out of the thought that t cell harm means opportunistic infections only
Immune dysfunction can come in many shapes and forms, autoimmunity, pathogenic priming, inflammation
Does not mean a hit would only manifest in opportunistic infections.
Immune dysfunction can come in many shapes and forms, autoimmunity, pathogenic priming, inflammation
Does not mean a hit would only manifest in opportunistic infections.
However, if Long Covid's stimulation and T cell aging is persistent, the sloughing could progress into the other subsets, not just Tn... but noone knows if that is the case
If that were the case it would be easily addressed bc it is not a retrovirus.
If that were the case it would be easily addressed bc it is not a retrovirus.
The Tn depletion could be self-limiting or progressive
Noone knows
They did find replicating virus in breast tissue
Could address reservoirs with antivirals
Noone knows
They did find replicating virus in breast tissue
Could address reservoirs with antivirals
In acute infection, EBV and CMV reactivate (reads go up) transiently in the immune dysregulated state in a recent publication
This is a transient reactivation of Latent viruses due to acute T cell count drops
The T cell counts go back up
sciencedirect.com/science/articl…
This is a transient reactivation of Latent viruses due to acute T cell count drops
The T cell counts go back up
sciencedirect.com/science/articl…
This is not a Primary infection with an opportunistic disease, like PCP pneumonia
This is a reactivation of latent virus in an acute state due to temporary hypoimmunity.
The trend reverses
This is a reactivation of latent virus in an acute state due to temporary hypoimmunity.
The trend reverses
So, do not go around saying "AJ can't be right bc we don't all have PCP pneumonia"
NO
All I was saying is that covid-19 reinfections can be worse due to loss of naive t cells and our future immunity can be harmed. Doesn't mean PCP pneumonia and Kaposi's!
NO
All I was saying is that covid-19 reinfections can be worse due to loss of naive t cells and our future immunity can be harmed. Doesn't mean PCP pneumonia and Kaposi's!
However, the persistent Tn depletion that may be ongoing...
That is worth watching to see if it is self-limiting or progressive
If progressive, treat with antivirals.
That is worth watching to see if it is self-limiting or progressive
If progressive, treat with antivirals.
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