You guys are using old thinking and old intuition
A solitary loss of naive T cells would not cause immunocompromise
On the contrary, it would cause immune overexuberance
My published statement is that Naive T cells dampen effector responses
A solitary loss of naive T cells would not cause immunocompromise
On the contrary, it would cause immune overexuberance
My published statement is that Naive T cells dampen effector responses
You guys get another thing wrong. The T cell 'exhaustion'
In sars cov 2 infection, that is a way of preventing overshooting activation in the younger population.
These are, on the surface, paradoxes, until the mechanism is understood
In sars cov 2 infection, that is a way of preventing overshooting activation in the younger population.
These are, on the surface, paradoxes, until the mechanism is understood
SARS Cov 2 burns the T cells at both ends, killing terminally differentiated via FAS and precociously aging the Naive by bystander activation and the feed-forward controller, but this manifests in immune exuberance.
In order to get immune compromise you would need the collapse of the absolute lymphocyte count. This is different from the differentiation status of the T cells in the blood.
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