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Anthony J Leonardi, PhD, MS Profile picture
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Mar 18 • 7 tweets • 3 min read
wow sars cov 2 is killing T cells nature.com/articles/s4141…
wow sars cov 2 causes more acute apoptosis than HIV biorxiv.org/content/10.110…

(actually I'm not surprised, I expected this)
Holy Moly sars cov 2 is causing T cell mediated autoimmunity in an unprecedented mechanism! frontiersin.org/articles/10.33…
Holy moly cd8 t cells causing PASC/ long covid! science.org/doi/10.1126/sc…
Oh wow T cells go to your brain in sars cov 2 infection but not in flu!
Maybe steroids work in part by dampening T cell responses huh? but this is more clinical knowledge than path ;)
My word sars cov 2 is getting rid of naive t cells nature.com/articles/s4159…

(i am not surprised)

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
Mar 17
Looks like hybrid immunity did not confer additional protection from hospital admission than just the vaccine alone.

thelancet.com/journals/lance… Image
This is a point towards my hypothesis that breakthroughs do not confer an additive protection. It is capped
To spell it out, this implies you roll the dice for severe disease (hospitalization) each subsequent time at equal rates. I am wondering if there will be decompensation with further breakthroughs.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 16
Don't know what else you guys can ask of me, a single T cell immunologist, in accuracy and foreshadowing

Here are two major things I foreshadowed

I anticipate the loss of Naive T cells here
1/2
I anticipate the Fas-mediated apoptosis here

2/2
My next foreshadowing is granular; the increased rate of severe disease in those with previously more moderate courses due to the loss of naive T cells in those without early, sera-mediated control of SARS Cov 2.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 16
You guys are using old thinking and old intuition

A solitary loss of naive T cells would not cause immunocompromise

On the contrary, it would cause immune overexuberance

My published statement is that Naive T cells dampen effector responses
You guys get another thing wrong. The T cell 'exhaustion'

In sars cov 2 infection, that is a way of preventing overshooting activation in the younger population.

These are, on the surface, paradoxes, until the mechanism is understood
SARS Cov 2 burns the T cells at both ends, killing terminally differentiated via FAS and precociously aging the Naive by bystander activation and the feed-forward controller, but this manifests in immune exuberance.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 15
Wow. guys in my publications (2020 and 2022) I say Tn depletion would cause some worse reinfections

NOT cause opportunistic disease

Don't put words in my mouth

The only person I saw who said opportunistic infections was Brian
from 2020. More severe reinfections from a contraction of the Naive T cell population. Image
However, unpublished, I have suggested that harm to the CD8 repertoire could mean people were worse at fighting EBV, HPV, and some immunogenic cancers.

Those are NOT opportunistic infections
Read 10 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 15
People seem to (intentionally) not understand my theory.

If naive T cells soak exuberance like cytokine sinks
AND
Naive T cells are depleted by Covid
THEN
SOME reinfections can be more severe
You are either Naive or Brian Hjele if you think that a naive T cell depletion would manifest in opportunistic infections.
Opportunistic infections manifest when T cell counts are low NOT when subsets are missing

However, missing subsets can portend T cell dysfunction and loss in the future

It depends on whether the T cell aging is progressive or not.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 9
Omicron reverted to reacquire the pathogenic features and now that pathogenic Omicron is kicking off a wave in a country with 97% immunity

Crazy

Did you all expect this?

If you listened to me you may have ;)
That's the good news. The bad news is that we won't have an updated vaccine in time. We update vaccines for flu every season, but not sars cov 2.
Been busy lately but I'm not a fairweather friend, friends :)

When the storm comes, you'll find me.

I'm a badweather friend ;)
Read 4 tweets

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