New paper published in @bmj_latest : “Association between covid-19 vaccination, SARS-CoV-2 infection, and risk of immune mediated neurological events: population based cohort and self-controlled case series analysis”. A 🧵 bmj.com/content/376/bm…
1) previous reports and research have suggested an association between some #CovidVaccines and immune neurological conditions including facial paralysis and Guillain-Barré syndrome. We had access to unique data to study this, and to research if #COVID19 itself can cause these
2) we studied data from Catalonia and the UK, including over 8 million vaccinated, 0.5m #covid19, & >14 million unvaccinated uninfected (historical data). We estimated rates of neuroimmune events post-vaccine and post-infection, and compared these to background (expected) rates
3) the rates of facial palsy, guillain-barre and encephalomyelitis post-vaccine were equivalent to expected, suggesting no association between any of the studied #CovidVaccines & these outcomes
4) however, rates post #COVID19 were 1/3, 3.5-fold and 6-fold higher than expected for facial palsy, GBS, and encephalomyelitis respectively
5) conclusion: we did not find an association between covid vaccines and neuroimmune conditions.. but it is likely that #COVID19 can cause some of these conditions
6) the study has limitations. Please read the whole paper. However, these data suggest, once more, that #COVID19 in the unvaccinated is far worse than #covidvaccines . Get vaccinated
Ps. Thanks to the awesome team that led this work ( @xtlxt @raventosb @TDuarte_Salles @CSMOxford @ndorms @UniofOxford @IDIAPJGol @HdsErasmusMC ) & to our funders @IMI_EHDEN @NIHRresearch @OxfordBRC
Let me end this thread by thanking the @ohdsi community, who mantain the OMOP common data model, and analytical pipelines that were at the core of our work. We stand on the shoulders of giants #jointhejourney
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