Biotech2k Profile picture
Mar 17 6 tweets 1 min read
Taking a Look at $PACB:

An updated look at Pacific Biosciences.
1/ I prefix this as sequencing companies is not in my space of expertise so my numbers or expectations may be off. I do like the company as my play on sequencing in the Genomics space.
2/ Management

I have been in Pacific Biosciences for only a short time, but I think Christian Henry is doing good so far. It will take a while to really know how good he really is at running this company.
3/ Science

They make the machines and consumables for sequencing DNA. They are commercial with their long read sequencing. They bought Omniome which is developing short read sequencing. I think together they will offer a good balance of both technologies.
4/ Potential

I am not an expert in the sequencing space, but I think they could grow their market share to around $1 billion in long term revenues as they continue to grow in long read and expand into short read.
5/ Value

I think they offer a good value down here at $2.27 billion market cap. They have $1 billion in cash and burned about $181 million in 2021. They have plenty of cash for 2 years. They have $130 million in 2021 revenues growing 65% year over year.

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More from @Biotech2k1

Mar 19
Looking at a little strategy:

Sharing some strategy while the sector is still down.
1/ I pick science themes like the use of #AI or #ML in drug discovery. Then I go out and find every company I can in that space. I make myself a list and start doing my research. I slowly whittle down the crowd to 5 names that stand out.
2/ Then I go further into the companies with listening to webcasts so I get to know if the management knows their stuff. I dig into the science and data. I even read the 10K or S-1 and understand the balance sheet. Then I look at the indications and the potential.
Read 17 tweets
Mar 19
Taking a Look at $IPSC:

An update look at Century Therapeutics.
1/ Management

I have only been in Century Therapeutics for a short time. I got a chance to listen to Lalo Flores present a few times. He does not come across as a great speaker.
2/ I don't think that is a deal breaker, but it does make me more cautious. It will take time to know how well he is doing with the business and clinical development.
Read 9 tweets
Mar 18
$IPSC is building alloevasion NK an gamma/delta T cells. They will be moving their NK for CD19 into clinic this year. This will be one of the first alloevasion NK cells in the clinic with $SANA. They knock out the HLA-I, HLA-II and insert the HLA-E to block NK cells.
1/ This will give us the first look at the CD47 vs HLA-E in preventing NK cells and/or Macrophage from cell killing. Image
2/ Their CNTY-101 is their CAR-NK for CD19. This has the alloevasion and will be in the clinic later this year. The one this its missing is the enhanced CD16 so it can work powerfully with antibodies. That is the one disadvantage I think they have compared to $FATE.
Read 5 tweets
Mar 18
Taking a Look at $NTLA:

An updated look at Intellia.
1/ Management

I have only been in Intellia for a very short time. I think the new CEO, John Leonard, is doing a fantastic job. They have really expanding their pipeline and jumped into developing their own base editing program.
2/ They seem to be very ambitious now toward advancing the pipeline. They are staying on the innovation side of the science and not falling behind.
Read 12 tweets
Mar 17
Taking a Look at $SANA:

An updated look at Sana Biotechnology.
1/ Management

I have been in Sana since not long after the IPO. I think Steve Harr has done an outstanding job so far developing the science and business. He picked up a key license from Beam for CRISPR CAS12b for editing of the iPSC cells.
2/ Science

They have 2 very incredible platforms that complement each other with delivery using Fusogen and Cell engineering using iPSC and CRISPR technology.
Read 11 tweets
Mar 17
Taking a Look at $NVTA:

An update look at Invitae.
1/ Management

I have only been in Invitae for a few months, but I think Sean George is doing a great job. He has spent a lot of money over the past few years to build up a world class company. It is very important to build a company that is competitive.
2/ They will focus on profitability going forward. They said they will continue 40% + growth for many years while focusing on margins and cash burn. They will only do acquisitions if they add strong value.
Read 8 tweets

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