Is sex a critical factor for treating #AtrialFibrillation?❤️🩹
New #CardiovascularResearch study examines #SexDifferences in calcium handling & therapies in patients with #AFib
academic.oup.com/cardiovascres/…
Our tweetorial explains the findings⬇️👩🏫
@ESC_Journals @escardio #EPeeps (1/9)
New #CardiovascularResearch study examines #SexDifferences in calcium handling & therapies in patients with #AFib
academic.oup.com/cardiovascres/…
Our tweetorial explains the findings⬇️👩🏫
@ESC_Journals @escardio #EPeeps (1/9)
#Atrial #myocytes were isolated from patients with & without #AtrialFibrillation
Sex differences in #risk factors & therapies were considered in the analysis (2/9)
Sex differences in #risk factors & therapies were considered in the analysis (2/9)
To explore #SexDifferences in the mechanisms of #Afib, calcium handling was examined & calcium handling proteins investigated (3/9)
Stumbling out of the gate
Males with #Afib had reduced #calcium current density & a delayed decay, but not females (4/9)
Males with #Afib had reduced #calcium current density & a delayed decay, but not females (4/9)
Sparking the fire 🔥
#Calcium spark frequency & density were higher in females compared to males with #AFib
Sparks were not the result of increased SR loading
(5/9)
#Calcium spark frequency & density were higher in females compared to males with #AFib
Sparks were not the result of increased SR loading
(5/9)
Increased calcium sparks may be driven by higher ryanodine receptor phosphorylation at S2808 in females with #Afib (6/9)
Inward NaCa exchanger currents were higher & more frequent in females with #AFib, compared to males
These disturbances were not due to differences in NaCa exchanger expression (7/9)
These disturbances were not due to differences in NaCa exchanger expression (7/9)
Does #Afib require a tailored fix? 🪡
A2A receptor antagonism & #betablockers had more pronounced effects on females with #AFib (8/9)
A2A receptor antagonism & #betablockers had more pronounced effects on females with #AFib (8/9)
Key #SexDifferences identified in #AFib:
❤️⬇️ L-type calcium current density in males
❤️⬆️ ryanodine receptor phosphorylation, calcium sparks, & inward NaCa exchanger currents in females
The results support #SexSpecific therapies to manage #Afib (9/9)
❤️⬇️ L-type calcium current density in males
❤️⬆️ ryanodine receptor phosphorylation, calcium sparks, & inward NaCa exchanger currents in females
The results support #SexSpecific therapies to manage #Afib (9/9)
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