Biotech2k Profile picture
Mar 24 7 tweets 1 min read
Looking at $RXRX:

An updated look at Recursion.
1/ Management

I have only been in Recursion for only a few months. So far, I would say that Chris Gibson seems like a solid CEO. It will take more time to fully know how well he will navigate the clinical and commercial aspects of the busines, but so far he has done well.
2/ Science

This company uses robots to do millions of experiments per week and record all the data into their super computer. Combining that data with AI and Machine learning, they can discovery drugs.
3/ The first programs they are developing look at known chemical entities and possible new indications while their discovery programs take the data generated by the labs and use it to develop completely new drugs with new indications.
4/ Potential

I think there is a lot of potential in their 3 phase 2 programs. They have multiple early stage and discovery programs in progress. I could easily see their phase 2 programs earning well over $1 billion in potential revenues.
5/ They have 2 major partners with Genentec and Bayer. Both of these program have multiple potential indications with each having milestone and royalties. There could be upward of $14 billion in just milestones from these partners.
6/ Valuation

This company is very cheap at just $1.17 billion market cap. They have over $500 million in cash and burned $187 million in 2021. That gives them enough cash for about 2 years depending on the expenses of the phase 2 trials.

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More from @Biotech2k1

Mar 26
Taking a look at the #AI/#ML use in biotech:

This is all about using tech to lower the costs and improve the rates of success in drug development. We still see 90% of drugs that enter the clinic fail to reach commercial. They can cost over $1 billion do develop.
1/ The first company is $EVO. They have a suite of technology they use to help other companies develop drugs. They use both Transcriptomics and Proteomics along with AI and ML. They work with many partners and get a small royalty on the sales of products they help develop.
2/ I don't own them as I want companies with big potential. Getting just a small royalty isn't going to get a huge growth potential unless they have thousands of partners. This makes them lower risk, but also lower reward. That is good if you like that kind of company.
Read 19 tweets
Mar 19
Looking at a little strategy:

Sharing some strategy while the sector is still down.
1/ I pick science themes like the use of #AI or #ML in drug discovery. Then I go out and find every company I can in that space. I make myself a list and start doing my research. I slowly whittle down the crowd to 5 names that stand out.
2/ Then I go further into the companies with listening to webcasts so I get to know if the management knows their stuff. I dig into the science and data. I even read the 10K or S-1 and understand the balance sheet. Then I look at the indications and the potential.
Read 17 tweets
Mar 19
Taking a Look at $IPSC:

An update look at Century Therapeutics.
1/ Management

I have only been in Century Therapeutics for a short time. I got a chance to listen to Lalo Flores present a few times. He does not come across as a great speaker.
2/ I don't think that is a deal breaker, but it does make me more cautious. It will take time to know how well he is doing with the business and clinical development.
Read 9 tweets
Mar 18
$IPSC is building alloevasion NK an gamma/delta T cells. They will be moving their NK for CD19 into clinic this year. This will be one of the first alloevasion NK cells in the clinic with $SANA. They knock out the HLA-I, HLA-II and insert the HLA-E to block NK cells.
1/ This will give us the first look at the CD47 vs HLA-E in preventing NK cells and/or Macrophage from cell killing.
2/ Their CNTY-101 is their CAR-NK for CD19. This has the alloevasion and will be in the clinic later this year. The one this its missing is the enhanced CD16 so it can work powerfully with antibodies. That is the one disadvantage I think they have compared to $FATE.
Read 5 tweets
Mar 18
Taking a Look at $NTLA:

An updated look at Intellia.
1/ Management

I have only been in Intellia for a very short time. I think the new CEO, John Leonard, is doing a fantastic job. They have really expanding their pipeline and jumped into developing their own base editing program.
2/ They seem to be very ambitious now toward advancing the pipeline. They are staying on the innovation side of the science and not falling behind.
Read 12 tweets
Mar 17
Taking a Look at $PACB:

An updated look at Pacific Biosciences.
1/ I prefix this as sequencing companies is not in my space of expertise so my numbers or expectations may be off. I do like the company as my play on sequencing in the Genomics space.
2/ Management

I have been in Pacific Biosciences for only a short time, but I think Christian Henry is doing good so far. It will take a while to really know how good he really is at running this company.
Read 6 tweets

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