So, lots of vilification and even gloating (by some insufferable 💩s) at various countries now suffering dreadful omicron waves after having previously suppressed the virus and adopting a so-called #ZeroCovid strategy. One or two thoughts/observations.
1. "Told you so" really
isn't an appealing trait, whether you're actually right, or not...especially when you're discussing human suffering. Grow up, and grow a conscience.

2. The only people that use the zero term nowadays generally "were not fans" in the first place.

3. Being in favour of
suppressing virus spread ≠ lockdowns and ≠ zero C. We all recognise the game changing role that vaccines play, but they shouldn't be the only act in town.

4. Most hitherto "zero" countries had varying approaches, but almost all waves are coincident with relaxing protections.
5. This is understandable given the incredible transmissibility of Omicron which, remember, is ONLY less severe (in adults) cf delta for highly vaccinated populations. If you haven't got high 90s% in vulnerable populations then this is bad news...expect this is an issue in HK 😥
6. Even in our own highly vaxd country, we r seeing 1000s hospitalised and 100s of deaths every day. 3rd and 4th jabs were necessary to achieve this, we need to remember what a privileged position that is in relation to many other countries. How sustainable is it?

7. Most "zero"
countries won't have achieved the UK level of boosting, so given Omicron's ability to bypass antibodies unless recently boosted, is it any wonder there are problems?

8. Some context, please...clinical impact of a pandemic is proportionate to cases x severity x morbidity x time..
so, yes, HK is having a dreadful wave, and cases are high elsewhere. But, compare and contrast...NZ had ~10k cases, 6 deaths yesterday...UK had 950 deaths in the past week (yes, with many incidentals), and ongoing sky high prevalence (🙏 @ONS ) and currently over 16k hospitalised
...our toll over the pandemic is unbearable, never mind morbidity #LongCovidKids #LongCovid , but we seem very good at ignoring this at the moment, talking about COVID in the past tense...🤦‍♂️

9. SE Asian countries, NZ, etc may not have got the opening up quite right in terms of
Vax being high enough etc, but in contrast to Hancock's opinion, they have clearly fared better in terms of pandemic impact by whatever measures: health, economic, HCWs and health systems being intact, etc. Aside from border regs, NZ has actually spent less time in restrictions
than the UK.

10. Whether you achieve it by borders, TTIS, NPIs etc, suppression until vaccines were available is clearly the best course, I agree with @bealelab that some folks are rewriting history at present...this is confounded by the lagged, half-way house measures falling
short of effectiveness, leading to the need for all the harsher means to restore control. Those who influenced government in Autumn 2020 to ignore SAGE just bewilder me...

11. Sweden...just, don't. The reality of this is nothing like the rose tinted picture some minimisers
paint, and nothing like as good as some of it's close neighbours...

12. Things certainly are returning to "normal" in the UK, but I worry how sustainable this is. Behaviour is changing, as is the virus. How regularly will we need boosters? We still haven't protected most kids as
we have adults, and the dismantling of TTI and Genomic surveillance seems premature, at best...🤦‍♂️

13. Surely if we want normality, then making environments as safe and secure as possible is key? Technology combines with public health to improve air quality etc. @IndependentSage
14. Why were restrictions so damaging? We can't say they didn't have impact, and this was exacerbated by the vast gulf of health and socioeconomic inequality that has been polarising since 2010. The PPE scandals, parties and test & trace outsourcing are all the more shocking as a
result. Other countries were far more resilient in terms of social care, health and support structures. Deprivation maps onto COVID impact in the same way it does other measures of health inequity, foodbank use, working poverty...but its OK, "everyone can buy a test"...🤦‍♂️. See
our @IndependentSage briefing on this with @MichaelMarmot for more info...
15. Given their dreadful impact, you'd only ever want to do this once...but we've had three in the UK, albeit comprising different measures. The impact logically increases the later you leave it, just
maths really. Folks have made things out to be black and white, pro- or anti lockdown, when the reality is we r all against unless things get desperate. If we're concerned by the impact/benefit of lockdown, why act irresponsibly to make them more likely? #EOTHO, delays & inaction
in Autumn 2020, so-called data not dates in the road map despite the arrival of delta, late implementation of plan B, lack of mitigations in schools, public spaces and workplaces...
16. I've heard some say that we could have just moderated our behaviour, protected "the vulnerable
" and just got on with things...all very well through a massive retrospectoscope, but how did the UK population learn such behaviour, the scale of which at Xmas and last summer no doubt countered spread? I'll give you 3 guesses.
The tier system could have been a way to deal with
things along these lines, but these again suffered from poor messaging, inconsistencies, and a reluctance to act quickly and decisively, instead imposing half measures upon areas such as Manchester with seemingly no resolution. Remember, we had no vaccines back then...
17. Our
vaccines ARE the answer, but not alone, and not facing the exposure caused by unmitigated virus circulation. Each new layer of vaccination with the exception of boosting seems more reluctantly introduced, yet its patently clear that the demographic of the pandemic has changed. At
least this is thankfully not the case in many zero countries, but uptake can vary for different reasons.
18. COVID is still the highest cause of death by infection in the UK, but the risk for many is obviously diminished. Nevertheless, this situation is in flux, and many remain
at risk. Let us not repeat the mistakes of the past by pretending that health and socioeconomic inequality doesn't exist. I don't imagine that "the vulnerable" expect the rest of society to put lives on hold endlessly, or to live entirely risk free. But, we have an opportunity to
THIS time ensure that these people are not forgotten as society moves on. If something on the scale of a pandemic can't force change, then what can? We have the tools, knowledge and technology to make positive changes in this regard, but i imagine it's an easier ask if 1000s of
vulnerable people aren't already dead, morbid, or isolated.
19. Maybe living thru restrictions might remind us that simple things hold great value, and many vulnerable people do without. ZC might now just be a #, but rising cases now ≠ failure over 2 years. #areaunderthecurve

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More from @SGriffin_Lab

Mar 25
@EvolveDotZoo @wanderer_jasnah This is really interesting Oliver, I'd missed this...I'll email about some of our unpublished HCV stuff...

I personally don't believe that SARS2 will be oncogenic, but if persistent infection remains it can't be ruled out 100%.

However, sorry to be nit-picky, but latency isn't
@EvolveDotZoo @wanderer_jasnah the story here...
1. Yes, EBV undergoes latency, in different patterns, but latency associated gene expression is oncogenic in nature and can cooperate with BCR activation to induce malignancy, the nature of which can depend upon immune status (incl EBV) and the stage of B cell
@EvolveDotZoo @wanderer_jasnah diffn we're in. KSHV alternates between latency and lytic bursts to promote tumour growth and maintain persistence.
3. HBV and HPV don't become latent at all, they integrate (not always immediately for HPV), so abortive infection, but express dominant oncogenes (E6/7), or for
Read 7 tweets
Mar 19
Seeing a lot about how NPIs and policies haven't influenced recent waves of SARS2 infections and it's all down to the new uncontrollable variant that we're powerless to stop...
Sound familiar? It rhymes with malfa...
Promise not to mention endemicity 🤪, but this needs a 🧵
First, a couple of caveats...
1. I'm not in any way a card carrying epidemiologist.
2. See 1.

BUT, whilst I may have slight mathematical issues, I do understand the basics...

So, why can't we control cases of BA2 whilst BA1 is on the way down? Taking the second point, some
have said that BA1 going down means that we were completely justified relaxing all restrictions, that we're probably all immune, and that the fact that even on the way down prevalence eclipses 2021 doesn't matter...
Yes, it's tempting to say this, but association≠causation
Read 26 tweets
Mar 13
I hope @jburnmurdoch doesn't mind a QT, but re his article on SARS vs 'flu IFR - imo, a good thread as per, but some folks insist on just reading headlines...

My take? Well, the comparison has issues, many that John covers, but my main thought is:

Just look at what vaccines might achieve if they were part of a supported, multi-layered approach, rather than being left to tackle COVID alone...
First, let's deal with the comparisons. John rightly mentions multiple caveats such as the fact that seasonal flu waves last just a few months, and that, critically, at present SARS2 prevalence is VERY high (and going up), yet flu is
Read 35 tweets
Feb 21
Well...this is nice. Apparently, it's just been deaths as usual this winter, obv this whole pandemic thing actually only affects other countries...

BBC News - Covid isolation laws set to end in England
bbc.co.uk/news/uk-604469…
Now, obviously our vaccines mean that many of us are no longer in anywhere near the danger from SARS2 that we once were, but when I see people dismiss it as a cold I really worry for some people's grip on reality...
For starters, the delta/omicron waves with all these cases that
apparently don't matter, have led to over 23k deaths just since the farcical short sighted "freedom day" in July.
That's about 20-25% of the D614G/alpha wave in 2020/21, which was effectively pre-vaccine.
It may not be such a scary "peak", but area under the curve HT @chrischirp
Read 25 tweets
Jan 17
I had one of my overly-long, verbose threads half-written on this, but the more I thought about it, I figured it was just worth emphasising a few things, all of which - weirdly - began with P...
1. Patience. We're all sick of this 4 waves in, same

bbc.co.uk/news/health-59…
chances missed, same late (in)action. It's clear that SARS-CoV2 WILL become endemic eventually, but not yet. It's too well adapted to humans to burn out, elimination is challenging. The best we can hope for is a VERY low endemic set point...but we're not there yet.
Endemicity is
a state that means things are predictable because the number of people susceptible to infection balances the inherent transmissibility of the virus. So, three things enter a sort of equilibrium - immunity, environment, and viral evolution.
We are still VERY much in a dynamic
Read 29 tweets
Jan 8
This is wrong in so many ways.
Disease is a function of virus, host, and environment. Yes, omicron has some differences to Delta etc., but it's our vaccines, with an unpredictable element of prior infection that's changing, but not breaking the relationship between incidence
and severity.
Nonetheless, to use flu as a platitude is also unwise. The reference here is seasonal strains to which we have an element of cross protection in the community, but against which we also vaccinate.
SARS-CoV2 remains a recent zoonotic event against which we are racing
to build immunity as a population, speeded along by vaccination. It may become endemic, ie predictable, in the future, but that does not mean benign, and could take many years. Pandemic flu is also devastating, we would have no prior immunity again, but SARS2 also has differences
Read 5 tweets

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