Symptoms of #SARSCoV2 infections, caused the #Covid19#pandemic are not limited to the respiratory tract only and virus also affects other organs and tissues of body including the BRAIN. SARSCoV2 has been found in neurons in different brain regions. pubs.acs.org/doi/10.1021/ac…
Post SARSCoV2 infection, acute and subacute #neurologicalcomplications have been reported. One of these complications, the Loss of smell, is a common premotor symptom in Parkinson’s disease (PD).
This symptom and the recent reports of cases of Parkinsonism in relatively young patients after a SARS-CoV-2 infection suggests that there may be a link between SARS-CoV-2 infections and the development of PD.
The observed molecular interactions thus suggest that SARS-CoV-2 infections may have long-term implications and that caution is required in considering N-protein as an alternative target in vaccination strategies.
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Neuropathological changes with pronounced neuroinflammation have been described in individuals after lethal #COVID19, as well as in the CSF of hospitalized patients with neurological complications. mdpi.com/1579664#mdpiviruses via @VirusesMDPI
To assess changes can occur POST #SARSCoV2 infection, leading to mild-to-moderate disease, we investigated the brains of four rhesus and four cynomolgus macaques after pulmonary disease and without overt clinical symptoms.
Postmortem - Infiltration of T-cells and activated microglia in the parenchyma of all infected animals, even in the absence of viral antigen or RNA. Moreover, intracellular α-synuclein aggregates were found in the brains of both macaque species.