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Abraar Karan

@AbraarKaran

May 4

First human challenge studies of #SARSCoV2 of 34 subjects

academic.oup.com/cid/article/74…

“Viral shedding was first detected by qPCR of throat swab samples after a median of 40 hours (~1.67 days) and in throat samples after 58 hours (~2.4 days)”

“The viral load rapidly increased, reaching a peak as determined by qPCR in the throat at a median of 112 hours (~4.7 days) and in the nose at 148 hours (~6.2 days). The peak viral load was significantly greater in nasal than in throat specimens.”

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Abraar Karan

@AbraarKaran

Apr 15

@kprather88

1/ Just finished a grant proposal to bring N95 respirators & air filtration devices into high risk crowded homes to try & prevent transmission from index #covid19 cases during future waves. Thanks to many including @kprather88 for help in bringing aerosol experts onto the team.

2/ We hope to generate useful data through real world rollout of interventions for communities by bringing in resources that can prevent spread.

Hoping we secure the funding to be able to carry this work out!

3/ We will be providing the most comfortable N95 models out there such as the Vflex for this, not the old hardshell cup designs that people can hardly tolerate

Read 4 tweets

Abraar Karan

@AbraarKaran

Apr 7

1/ We are told to mask up, get vaccinated, get on with it

We are also told the government is funding #LongCovid research bc we don't know what we are dealing with or the long term costs to our health

2/ We are told to employ personal measures and be responsible

Yet we are dealing with an airborne virus for which personal responsibility is inadequate when we need engineering controls to better filter the air around us ASAP

3/ All over the world we blamed poor communities for perpetuating disease spread

Yet now polls are showing those communities are most likely to continue masking and taking precautions, despite having the least resources to do so

Read 6 tweets

Abraar Karan

@AbraarKaran

Apr 7

In the hospital, when we are dealing w/ airborne pathogens, not only do we wear N95 respirators—we also place patients in rooms with significantly higher air changes per hour/ negative pressure/ HEPA filters etc

If this is what is needed in hospitals, then what about the public?

2/ The irony is that many hospitalized #covid19 patients are less infectious than when they were in the community! They are suffering often from inflammatory effects of the virus & immune response. Peak infectiousness is often happening in places without enough air filtration

3/ Yet the response has essentially been “mask up & get vaccinated”

But vaccines are effective mostly for severe disease prevention. Not for infection prevention. So— we are essentially just being told to “mask up” (even that has stopped)

The ventilation/air quality question…

Read 4 tweets

Abraar Karan

@AbraarKaran

Apr 6

@gregggonsalves

1/ I have appreciated @gregggonsalves recent threads. One of the points to me is that there is a strange denial that is pervasive around #covid19. We have seen it come and go over the past 2 years; usually, it disappears when we are hit once again.

2/ The strange part of the most recent wave of denial is that a number of health experts joined in. I agree w/ them that vaccines are excellent; but there seems to be very little conversation or acknowledgment that wide-spread infections are a very bad thing when we know little

3/ abt long term costs of #covid19; &, because as immunity wanes & we deal with a more divergent variant in the future, we are no more prepared to deal with rapid airborne spread. Yet, many experts are in the business of reassurances to the public; ones that they can't guarantee

Read 6 tweets

Abraar Karan

@AbraarKaran

Apr 2

“Risk for cardiac complications was significantly higher after #SARSCoV2 infection than after mRNA COVID-19 vaccination for both males and females in all age groups.”

cdc.gov/mmwr/volumes/7…

2/ Remember this specific point came up many times — will those who brought special attention to questioning risk of vaccines but not questioning risk of infections w the same scrutiny now address this?

3/ “Even among males aged 12–17 years, the group with the highest incidence of cardiac complications after receipt of a second mRNA COVID-19 vaccine dose, the risk was 1.8–5.6 times as high after SARS-CoV-2 infection than after vaccination.”

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