Location matters for Covid Vaccine.
Booster Vaccination on the same side as the original Prime shot produces better quality antibodies than on the opposite side even though antibody titres were similar #CovidVaccine @VirusesImmunity #Immunity 1/n
science.org/doi/10.1126/sc…
Booster Vaccination on the same side as the original Prime shot produces better quality antibodies than on the opposite side even though antibody titres were similar #CovidVaccine @VirusesImmunity #Immunity 1/n
science.org/doi/10.1126/sc…
Booster Vaccination on the Ipsilateral (same) side produced higher avidity antibodies as opposed to booster on the contralateral (opposite side), #CovidVaccine 2/n
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
Affinity vs Avidity
Affinity is the strength of a single antibody binding its cognate epitope whereas avidity relates to the strength of polyclonal antibodies (like in real antibody responses) binding to antigens as different antibodies can bind to different epitopes 3/n
Affinity is the strength of a single antibody binding its cognate epitope whereas avidity relates to the strength of polyclonal antibodies (like in real antibody responses) binding to antigens as different antibodies can bind to different epitopes 3/n
What is the secret behind higher avidity (and likely higher affinity for individual antibodies)?
Study shows that antibodies produced by ipsilateral vaccine booster produced more somatic hypermutation, a key step in affinity maturation in germinal centers. 4/n
Study shows that antibodies produced by ipsilateral vaccine booster produced more somatic hypermutation, a key step in affinity maturation in germinal centers. 4/n
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