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𒀭Dr Able Lawrence MD DM🦉周天堂🌻 Profile picture
𒀭Dr Able Lawrence MD DM🦉周天堂🌻
@abledoc
Prof Clinical Immunology & Rheumatology; Foodie Birder Photography Axiology Statistics Nerd Vajrasattva $TSLA #RenewableEnergy #EvoBio #Wine #FMS
2 subscribers
Nov 4, 2022 • 6 tweets • 4 min read
Ensitrelvir or S-217622, a potent inhibitor of SARCov2 main protease from Japan shows activity against COVID19 Variants of concern in animals studies and is poised to enter clinical trials.
#COVID19 #Ensiltrevir #Japan #ProteaseInhibitor #S217622
science.org/doi/10.1126/sc… Ensiltrevir blocks SARSCov2 Main protease after viral entry. #Ensiltrevir science.org/doi/10.1126/sc…
May 19, 2022 • 37 tweets • 24 min read
Monkeypox is an Orthopoxvirus like Small Pox or Vaccinia virus. They are brick shaped linear dsDNA viruses that replicate in cytoplasm. They bind to glycosaminoglycans to enter cells or are taken up by apoptotic mimicry #monkeypox #orthopoxvirus 1/n
viralzone.expasy.org/149?outline=al… Small Pox is the archetypal orthopoxvirus infection of humans which infected humans from prehistory until its eradication in the 20th century through Vaccination. First true success of Vaccines 2/n #Variola #SmallPox #orthopoxvirus
thelancet.com/journals/lance…
May 8, 2022 • 4 tweets • 3 min read
Location matters for Covid Vaccine.
Booster Vaccination on the same side as the original Prime shot produces better quality antibodies than on the opposite side even though antibody titres were similar #CovidVaccine @VirusesImmunity #Immunity 1/n
science.org/doi/10.1126/sc… Booster Vaccination on the Ipsilateral (same) side produced higher avidity antibodies as opposed to booster on the contralateral (opposite side), #CovidVaccine 2/n
science.org/doi/10.1126/sc…
Jan 8, 2022 • 6 tweets • 3 min read
Early use of high titer neutralisatiing Convalescent Plasma in outpatients reduce hospitalisation. 1/n
#COVID19 #PlasmaTherapy
medrxiv.org/content/10.110… So what was wrong with previous attempts at Plasma therapy?
1) Reliable assays for Neutralising Antibodies werent widely available earlier
2) We did not know what titer was high enough
3) Most studies were done in serious ill hospitalised patients 2/n
Jan 6, 2022 • 5 tweets • 3 min read
Pointless bureaucratic torture “endless meetings where you know nothing would get done” forces @SpaceXStarlink India chief to quit, in huge setback to the image of India as a business friendly destination. @SpaceX @NITIAayog #StarLink
republicworld.com/india-news/gen… Image
Jul 28, 2021 • 8 tweets • 6 min read
Shielding Strategy where high risk individuals in UK were told to "shield" themselves from #COVID19 a huge failure in Scotland as the shielded subjects contracted severe covid at higher rates. @dgurdasani1 @PaulNuki @pash22 #shielding #SARSCovid2
bmcmedicine.biomedcentral.com/articles/10.11… High Risk Individuals eligible for shielding had higher exposure to hospitals.
bmcmedicine.biomedcentral.com/articles/10.11…
Jul 27, 2021 • 4 tweets • 3 min read
What has been the true extant of the COVID19 pandemic in United states after accounting for underdiagnosis and misreporting? The pandemic still has a long way to run its course. #COVID19
pnas.org/content/118/31… Has United States reached sufficient levels of Immunity to prevent another wave. While 80% of the popultion may have some immunity, this is subject to R0
R0 started at 6, and the virus has become 2.5 times more infective. Probably higher levels needed.
pnas.org/content/118/31…
May 6, 2021 • 9 tweets • 4 min read
"Social Distancing" is a term coined by (math inclined) epidemic modellers and misunderstood by public & even by most public health "experts"
So what does it mean. 1/n
Lets start with the factors affecting R0 (Basic Reproductive Rate) that critically determines an outbreak... R0 (Basic Reproductive Rate)
= (Avge number of people one meets in a day) * (Probability of Transmission) * (Number of Infective days)
Thus R0 is not a fixed number but influenced & modified by behaviour.
Meeting & interacting with fewer people reduces R0 (Social Distancing) 2/n
Jan 24, 2021 • 5 tweets • 2 min read
Bats are diverse. There exists 1423 known species, with considerable sequence variation in viral receptors (eg DPP4 and ACE2) increasing the likelihood that mere exists a coronavirus variant that spilling into humans. DPP4 is the receptor for MERS while ACE2 is the receptor for SARS. The variation in these receptors among bats greater than that between humans and other species of mammals. We still don't know the identity of bat species from which COVID19 came.
Jan 22, 2021 • 12 tweets • 3 min read
Here is a thread on what people with heart disease should consider before taking vaccine 1/n
People with heart disease are at increased risk from COVID19 not only due to heart disease but also from diabetes & hypertension. Thus benefits of vaccination are greater. Now the nuance Reports of sudden deaths following vaccination have received widespread coverage, mostly in the old (Norway) as well as young (Karnataka, India & Portugal) attributed to Cardiac events. This has to be seen against millions vaccinated. Risk of COVID19 death above 70 is 14% 2/n
Jan 5, 2021 • 14 tweets • 13 min read
BirdFlu outbreak in India #BirdFlu #H5N8 #H5N1 #BirdFlu2020 #HPAI #AvianFlu
Are we dealing with one outbreak or two separate outbreaks of H5N8 and H5N1 strains?
This is a thread on the BirdFlu Outbreak, analysing what we know so far and potential risk 1/n
timesnownews.com/india/article/… Here is an excellent compilation of BirdDeath events across India. @birdcountindia affiliated with eBird.org is a science project promoting cataloging BirdRecords in India. You would find lists of events with links here 2/n #BirdFlu
birdcount.in/dead-or-dying-…
Nov 29, 2020 • 4 tweets • 3 min read
Reliance Jio Customer Torture Service is the worst customer outreach program in existence.
My big mistake porting my mobile number from BSNL (another Jio success story in turning a great public facility to dust) to Reliance Jio network. @reliancejio @reliancegroup #Jio 1/n I got an SMS on a Saturday afternoon before an extended weekend informing me that there was small unbilled amount with my previous service provider BSNL & hence Jio is disconnecting my services. Immediately my phone lost signal & network. Not even SMS or OTP possible 2/n Image
Aug 26, 2020 • 7 tweets • 3 min read
Germinal Centre defects in severe COVID19 patients who died cripples effective antibody response. It probably explains why it takes upto 4-5 weeks (incubation upto 2, then 2-3) for antibodies to form. 10% produce no antibodies at all. #CovidImmunity
sciencemag.org/news/2020/08/c… Short lived nature of the antibody response after COVID19 infection makes dreams of Herd immunity from natural infections a mirage if ever it was even a thing. OTOH, vaccines "may" produce long lived antibodies, particularly with the RNA vaccines.
sciencemag.org/news/2020/08/s…
May 14, 2020 • 10 tweets • 7 min read
Asians & others with darker skin living in Northern latitudes are prone to Vitamin D Deficiency? Severe COVID19 males had lower vitamin D levels. (Females take more supplements) Vitamin D plays key roles in cardiovascular & immune systems 1/n #VitaminD
blogs.scientificamerican.com/observations/a… Vitamin D regulates the expression of PLC-γ1 in naive T cells & is key to T cell responsiveness in humans. Poor primary T cell response can affect immune responses to viral infections including influenza & coronaviruses. 2/n @Ms_Aflatoon #VitaminD
nature.com/articles/ni.18…
Apr 20, 2020 • 7 tweets • 4 min read
@nntaleb There are sufficient mechanistic studies to believe there could be a synergy between Zinc and Hydroxychloroquine.
Zinc has activity against multiple virus families including coronavirus.
Hydroxychloroquine is a Zinc chelator and potentiates Zinc effects. Will post references 1/n @nntaleb Zn2+ Inhibits Coronavirus and Arterivirus RdRP RNA dependent RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture 2/n
journals.plos.org/plospathogens/…
Mar 18, 2020 • 4 tweets • 4 min read
This is a thread on use of drugs for #COVID19
Hydroxychloroquine (Lupus, RA) Lopinavir/Ritonavir (HIV/AIDS) Remdisivir and Favipiravir (Ebola) and Camostat (Pancreatitis, Japan) are drugs that seem to have activity against SARSCov2
Some of these are used on Emergency Basis. 1/n Image Potent nucleoside antiviral drug from Emory University shows broad spectrum activity against corona viruses including Remdisivir resistant strains. Acts by targeting RdRp to increase RNA mutation rates. @EmoryUniversity #EIDD2801 #COVID19
#coronavirus 1/n
news.emory.edu/stories/2020/0… ImageImage