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Kevin C. Klatt, PhD, RD Profile picture
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May 16 • 3 tweets • 3 min read
New publication 🚨 Our RCT + isotope tracing detailing a significant nutrient-nutrient interaction during pregnancy between choline and docosahexaenoic acid (DHA; omega 3) is now online @AJCNutrition. A thread ⬇️
academic.oup.com/ajcn/advance-a… #RDchat #Metabolism #Obgyn #obstetrics
Nice write up of our study from @CornellNews! @CornellNutri @CornellCALS @CornellCHE
Nice write up of our trial from @NutraUSA! nutraingredients-usa.com/Article/2022/0…

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More from @KCKlatt

Kevin C. Klatt, PhD, RD Profile picture
May 23
With more discourse about postdocs and how to 'fix' them, think we need more broad imaginative restructuring of the research workforce, incl a gov funded 'research scientist' career option. We should retain scientists in academia thru non-8yr postdoc /TT prof mechanisms.
the supply/demand is so whacked for the PhD stud -> postdoc -> prof pipeline and oscillates every decade. Academia hemorrhages talent that just wants to do research & is trapped in postdoc purgatory hoping to land a TT prof position even tho they dont want to be managers/teachers
We put so much money into training a scientific workforce, and its great a bunch go to industry!, but the lack of options for retaining some of this in academia is so so so bad for science, the quality of research & training, i can't overstate this enough.
Read 4 tweets
Kevin C. Klatt, PhD, RD Profile picture
Nov 18, 2020
Tons of chatter about the new prescription omega 3 data coming forth. Lots of takes about the study designs, n3 formulations, differences across populations, variation in comparator groups. All important ?- but I think there's a bigger 🐘in the room. #cardiotwitter #lipids #AHA20
Intervening with n3 fatty acids is unlike other drugs bc they are a nutrient. There is no placebo for n3s in the sense that:

1) you have questions about what is the ideal comparator; typically isocaloric oil.

2) you don't have an unexposed group - there are endogenous levels.
There are numerous reasons for n3 enthusiasm, but playing by evidence hierarchy, the top reason is that meta-analyses of cohorts demonstrate that higher blood levels of n3s result in reduced risk of fatal CHD jamanetwork.com/journals/jamai…
Read 18 tweets
Kevin C. Klatt, PhD, RD Profile picture
Sep 11, 2020
preprint servers are a gem. Giving inpatients your brother's company's magical nutrient cocktail, stating informed consent but no mention of IRB approval/oversight. Called a retrospective case series? Sounds about 2020.
Cc @MicrobiomDigest
papers.ssrn.com/sol3/papers.cf…
I cannot imagine going bedside and doing this
And the preprint is down
Read 4 tweets
Kevin C. Klatt, PhD, RD Profile picture
Mar 24, 2020
Folks keep citing this BMJ analysis to push for #vitaminD supps right now. It's not unreasonable to think about VitD but there's very imprecise language going around that "Vitamin D deficiency" is very widespread. This is hotly debated .bmj.com/content/356/bm…
Most folks are citing that many individuals are below 30ng/mL which is the threshold that @TheEndoSociety rec'd in 2011 following the 2010 @NASEM_Health report. There aren't trials treating folks with low -> 30+ng/mL to support the rec,it's mostly epi work and basic bio rationale
The BMJ paper comes in cause folks are saying that it supports a role for VitaminD suppvto reduce respiratory tract infections and may be useful against corona, and there's a high prevalence of VitD deficiency in the population. Makes sense?
Read 8 tweets
Kevin C. Klatt, PhD, RD Profile picture
Jan 17, 2020
What a fear-mongering headline. The treatments didn't cause genetic changes; they caused changes in the way the genes are expressed in the brain. This isn't too surprising given that the 2 soy diets (high PUFA; high oleic) significantly ⬆️weight, worsened glucose tolerance.
it's also been known for quite a while that coconut oil high fat diets don't induce MetS in rodents. There is something weird about them. this was a major area of exploration for my dissertation work ( clinicaltrials.gov/ct2/show/NCT03…). Headline cld easily be "Coconut Oil is Special"
can go back to 2006 and find data that CO and high fish oil diets don't do what high lard and high olive oil diets do for inducing insulin resistance in rats.
ncbi.nlm.nih.gov/pubmed/16720718
Read 8 tweets

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