Your regular reminder that dietary guidelines are heavily based on, and constrained by, experimental nutrition data. The idea that it's all observational sata is misguided, & often stated by folks who are ignorant of the history of nutrition and not acting in good faith💲💰.
Are there loud people in the field who primarily generate and argue from prospective cohort studies? Absolutely.
Doesn't change that most guidelines are based on nutritional adequacy (predominantly experimental data) & chron dz prevention (mix of exp data & observ data).
May 23, 2022 • 4 tweets • 1 min read
With more discourse about postdocs and how to 'fix' them, think we need more broad imaginative restructuring of the research workforce, incl a gov funded 'research scientist' career option. We should retain scientists in academia thru non-8yr postdoc /TT prof mechanisms.
the supply/demand is so whacked for the PhD stud -> postdoc -> prof pipeline and oscillates every decade. Academia hemorrhages talent that just wants to do research & is trapped in postdoc purgatory hoping to land a TT prof position even tho they dont want to be managers/teachers
Nov 18, 2020 • 18 tweets • 6 min read
Tons of chatter about the new prescription omega 3 data coming forth. Lots of takes about the study designs, n3 formulations, differences across populations, variation in comparator groups. All important ?- but I think there's a bigger 🐘in the room. #cardiotwitter#lipids#AHA20
Intervening with n3 fatty acids is unlike other drugs bc they are a nutrient. There is no placebo for n3s in the sense that:
1) you have questions about what is the ideal comparator; typically isocaloric oil.
2) you don't have an unexposed group - there are endogenous levels.
Sep 11, 2020 • 4 tweets • 1 min read
preprint servers are a gem. Giving inpatients your brother's company's magical nutrient cocktail, stating informed consent but no mention of IRB approval/oversight. Called a retrospective case series? Sounds about 2020.
Cc @MicrobiomDigest papers.ssrn.com/sol3/papers.cf…
I cannot imagine going bedside and doing this
Mar 24, 2020 • 8 tweets • 3 min read
Folks keep citing this BMJ analysis to push for #vitaminD supps right now. It's not unreasonable to think about VitD but there's very imprecise language going around that "Vitamin D deficiency" is very widespread. This is hotly debated .bmj.com/content/356/bm…
Most folks are citing that many individuals are below 30ng/mL which is the threshold that @TheEndoSociety rec'd in 2011 following the 2010 @NASEM_Health report. There aren't trials treating folks with low -> 30+ng/mL to support the rec,it's mostly epi work and basic bio rationale
Jan 17, 2020 • 8 tweets • 3 min read
What a fear-mongering headline. The treatments didn't cause genetic changes; they caused changes in the way the genes are expressed in the brain. This isn't too surprising given that the 2 soy diets (high PUFA; high oleic) significantly ⬆️weight, worsened glucose tolerance.
it's also been known for quite a while that coconut oil high fat diets don't induce MetS in rodents. There is something weird about them. this was a major area of exploration for my dissertation work ( clinicaltrials.gov/ct2/show/NCT03…). Headline cld easily be "Coconut Oil is Special"
