First of all, I have no COIs with any makers of sunscreen! Even so, I'm going to avoid talking about any brands. Instead, we'll focus on the different factors you should consider when picking your favorite.
What is your current preference for sun protection (if any)?
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There's debate in the field right now about whether everyone even needs sunscreen. For this #tweetorial, I'm going to focus on those who've decided they need sun protection.
So 1st rec: The best sunscreen is one you'll actually put on. Doesn't matter if you won't use it!
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Ok, let's get into it. What is SPF?! Here's a nice website from the @US_FDA about what it is. In short, it's a measure of how MUCH UV your skin can take before it burns (compared to unprotected skin), NOT a measure of how long you can have UV exposure. 4/
Remember though that sunscreens are tested in ideal lab settings. That means that if you don't put enough of it on, you aren't getting to the same level of protection as "proven" in laboratory testing.
So while yes, SPF effect plateaus after 30, that was done in the lab! 5/
So how do we use this in the real world?
1) Pick a higher spf! I say minimum spf 50 b/c that way if you don't put enough on or don't reapply enough, you perhaps are getting to at least an spf30 equivalent.
2) Put enough on! One shotglass full with each application. 6/
So SPF blocks UVB, but what about UVA? We don't have a clear number to shoot for in terms of blocking UVA, so the best advice I can give is to make sure you pick a sunscreen that has "broadband" protection across the whole UV spectrum.
Remember
uvB ➡️ Burns
uvA ➡️ Aging
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But what about physical vs. chemical blockers?!
Physical blockers are the sunscreens whose main ingredient includes Zinc or Titanium.
Chemical blockers include ingredients that sound like they're in an orgo textbook😬
Both work as well as their SPF would suggest! 8/
The main drawback of physical blockers is how they look/feel when they go on. They are (usually) the ones that go on super white and can't be rubbed into the skin as easily.
In the article, the authors measured plasma levels after sunscreen use and found that the chemicals were absorbed at higher levels than previously thought. Importantly, they don't delve into downstream consequences, but this understandably made many nervous! 10/
So what does that mean? I'll just share that in our family, we make sure to use physical blockers on the kids, but my partner and I still use chemical blockers.
But I'm sure others of #dermtwitter have their own opinions! 11/
Okay, what about spray on versus smear on?
Tbh, I don't think there's a huge difference except real world outcomes. Those that use spray on often apply too little, and you can't as easily tell what areas you've missed. So be sure to apply enough if that's your preference! 12/
There was another sunscreen scare where a bunch of spray-on sunscreens were recalled because benzene (a known carcinogen) was found in them.
BUT, the concentrations were super low, and it wasn't a problem with the spray on sunscreen per se, but rather how it was made.
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And how should we actually apply it? I already went over how much to use, but the UV protection only lasts for ~2-3 hours, even shorter if it's when the UV index is super high!
So I advise my patients to apply every 2 hours, or more frequently if they are sweating/swimming! 14/
Finally - don't forget there are SO many ways other than sunscreen to protect yourself.
✅ Sun protective clothing that's well UPF rated.
✅ Avoiding sun between 10 am and 2pm.
✅ Using wide-brimmed hats that cover the ears! 15/
SUNSCREEN RECAP:
👉SPF is from ideal lab conditions. Use higher SPF and enough sunscreen (1 oz per application).
👉Use broadband protection to include UVA.
👉Physical blockers less likely to be absorbed, but downstream effects of chemical absorption unknown.
👉Avoid benzene!
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But at the end of the day, what does this mean for me and my family?
For us👇
Kids: Smear on physical blocker, at least SPF 50, applied every 2 hours, or more frequently with high UV, sweating, swimming.
My partner and I: Same as above, but okay with chemical blockers. 16/
Hope this #dermtwitter#tweetorial is helpful not just for counseling your patients, but also for you and your loved ones.
Hi #medtwitter and #dermtwitter! Since I'm giving a talk at the upcoming @SocietyHospMed Converge meeting, I thought I'd put together a brief #tweetorial on:
DIFFERENTIATING PEMPHIGUS AND PEMPHIGOID!
Follow along for a reminder on how to tell them apart! 1/
Reminder that Pemphigus is from an antibody targeting the Desmosome - which holds skin cells (keratinocytes) together.
Pemphigoid is from an antibody targeting the Hemidesmosome, which holds keratinocytes to the basement membrane.
pc: 2/ bookdown.org/jcog196013/BS2…
So to remember:
pemphiguS (S for Superficial/higher up)
pemphigoiD (D for Deep/lower down)
This also means the clinical exam is different. Since Pemphigoid is deeper, these bullae stand tall and proud and don't droop over (see pic)! We call these TENSE bullae. 3/
If everyone could just humor me for a little, here's a #dermtwitter/#medtwitter/#pharmtwitter #tweetorial on...
AZATHIOPRINE
Did you know that dermatologists use this medication too? Read on to see all the ins and outs of safety and dosing, from a #dermatology point of view! 1/
Did you notice those two rings above? That's how it works.
Azathioprine is a purine (see figure) analogue, so it gets in the way of RNA/DNA synthesis (making transcription and replication and all that downstream goodness more difficult). 2/
And as you might imagine, cells that are rapidly dividing (like your immune cells) would be affected more by this purine disruption.
But it's not azathioprine itself that does all the work. It has to be broken down into active metabolites and that's where it gets interesting. 3/
The spirochete Borrelia burgdorferi is the most common cause. It is transmitted via tick bite, and so, certain areas of the country have higher rates based on endemicity of the organism.
What tick classically transmits lyme?
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Ixodes tick is the classic vector for B burgdorferi. But remember:
The tick usually has to be attached to the patient for >36 hours to transmit and cause Lyme disease.
Can you identify all these types of ticks and pick out which one is Ixodes?
We're seeing more consult questions for this, and it's also garnering national attention, so let's take a brief moment in #tweetorial format to talk about:
What is Xylazine? It was created in the 70s as a veterinary anesthetic. As an analog of clonidine, it has similar effects as an alpha-2 agonist, leading to sedation, anesthesia, and euphoria in the CNS. 2/
Recently, Xylazine has entered the drug supply, moreso in certain cities, but increasingly everywhere. It is often mixed with fentanyl as a cutting agent, and can also be used on its own. It may be called Tranq, Zombie Drug, or anestesia de caballo (horse anesthetic).
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Let's go back to the basics. Syphilis is from an infection by the bacterium Treponema pallidum. Usually spread by sexual means, syphilis has three main stages of disease.
Primary infection usually presents as a papule that turns into a painless ulcer called a chancre. 2/
Time from inoculation to chancre usually is 10-90 days (21 days is most typical).
There is a rare variant where the patient can get many smaller ulcerations, which is called Follman balanitis. 3/
Let’s spend some time in this #tweetorial on the dermatologic manifestations of this potentially paraneoplastic disease!
First, a question: What is necessary to make a diagnosis of DM?
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None of the above! DM is a clinical diagnosis, which is why getting the exam right is super important! That said a biopsy CAN help with getting to a diagnosis, but it’s not necessary.
So let’s start! Heliotrope rash! This poikilodermatous erythema occurs around the eyes. 2/
Remember though that exams are different across skin tone. Heliotrope can look a lot more subtle in someone with more melanated skin. That rash can also include the rest of the face! 3/