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Jun 9 • 4 tweets • 4 min read
Today is a BFD triumph in life science—solving the 3D structure at near atomic level resolution, one of the world's hardest, giant jigsaw puzzles—the nuclear pore complex—the largest molecular machine in human cells, with structure-based AI prediction
@ScienceMagazine
Extraordinary work and perseverance by multiple groups
science.org/doi/10.1126/sc…
This wouldn't have happened without #AI #AlphaFold
More NPC stuff
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
In case you are not familiar with the nuclear pore complex, it is in every cell of your body (that has a nucleus), comprised of >1,000 proteins, and connects everything from cytoplasm to nucleus, bidirectionally
nature.com/articles/d4158… by @ewencallaway @Nature

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More from @EricTopol

Eric Topol Profile picture
Jun 11
BA.4/5 is on the rise to become dominant in the US and UK. It hit South Africa and Portugal first. Note the difference in impact for those 2 countries in deaths Image
US cases are still rising, 7% increase week-to-week, >146,000 confirmed yesterday, current 7-day avg 112,000+, only a small fraction of the actual infections.
Hospitalizations closing in on 30,000 charts.medriva.com/us
UK cases & hospitalizations are starting to increase again ImageImage
Yet public officials in the US have apparently given up
washingtonpost.com/business/have-… by @fayeflam
Read 8 tweets
Eric Topol Profile picture
Jun 7
The US Omicron subvariant wave is now 62% BA.2.12.1, 5% BA.4 and 8% BA.5
covid.cdc.gov/covid-data-tra…
As BA.4 and BA.5 start to outcompete BA.2.12.1, regional differences
Why is this important?
Read 6 tweets
Eric Topol Profile picture
May 27
American exceptionalism
The United States comprises 4% of the world's population
✓ 16% of the world's Covid confirmed deaths
✓ 40% of world's guns
✓ Only industrialized nation in the world with states making abortion illegal
Confirmed Covid deaths, as of today
US 1,004,121
World 6,284,446
coronavirus.jhu.edu/map.html
"The United States has 46 percent of the world’s civilian-owned guns "
pbs.org/newshour/natio…
That was as of 2018, and has increased since then
Read 7 tweets
Eric Topol Profile picture
May 25
Just out @NatureMedicine
The natural history of post-vaccine breakthrough infections (BTI) in 33,000 people, >13 million controls
nature.com/articles/s4159…
@zalaly @BCBowe @Biostayan @WUSTLmed
—Vaccination protection from #LongCovid ~15%, much less than many other studies (~50%) Image
BTI relative risk and absolute excess burden at 6 months for death, particularly increased for clot-related, lung sequelae Image
Less risk of #LongCovid sequelae with BTI compared with unvaccinated Covid Image
Read 4 tweets
Eric Topol Profile picture
May 22
10 months ago.....
It took only 10 months from sequencing #SARSCoV2 to validation of mRNA vaccines with 95% efficacy in large, placebo-controlled, randomized clinical trials Image
Part of the Capitulation
erictopol.substack.com/p/the-covid-ca…
Read 4 tweets
Eric Topol Profile picture
May 17
The "Delta" (L452R) mutation found in both the BA.2.12.1 and BA.4/BA.5 variants is key to both immune escape and enhanced cell fusion (not present in BA.1 or BA.2). And people with prior Delta infections have better neutralization to these variants biorxiv.org/content/10.110…
The mutation map I attached (not in the preprint) was made from outbreak.info so if there are any questions, here is the link outbreak.info/compare-lineag…
Interesting new @NEJM report by same group, @ShanLuLiu1 and team @OhioState,
for Deltacron's (no L452R mutation, recombinant Omicron w/ Delta) substantial immune evasion with no enhanced sensitivity to serum from Delta wave nejm.org/doi/full/10.10…
Read 4 tweets

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