3/ To be sure, I'd echo @NutritionMadeS3's qualifier in the video that this is expected at a population level. So the exceptions don't prove the rule (in either direction).
Hence the enormous importance of studying those with extremely high LDL/ApoB at a population level...
1/ I'd love to take an opportunity to expand on this important topic, and if I may, suggest something important to watch for with some newly emerging data.
Design a VLC diet that is low in fiber with the goal toward reaching a low respiratory exchange ratio on a cohort of lean, fit athletes (but no other exercise confounding like resistance training or diet confounding like meds/sups, etc).
Full disclosure - @DrNadolsky and I took to some of this discussion via direct texting. However, it did lead me to a good question that I decided to turn into a poll out of curiosity...
1/2 Another great prop bet @DrNadolsky and I were discussing:
He proposed he could emulate the #LMHR phenotype by consuming a lot of butter and coconut oil while not keto and fat-adapted (thus, high RER). I'd predict the opposite.
1/ Two weeks ago we released our paper on the #LipidEnergyModel (#LEM) along with our video abstract for it. I'm pleased to say it has led to many great connections and expanded discussion.
I'm going to recap on a lot of these in this thread. 𧡠...
2/ First and foremost, thanks to everyone for their extraordinary support in retweeting our announcement, sharing our paper, and letting researchers know of this model.
3/ As we state many times (including within the video abstract), this model doesn't describe all possible influences on cholesterol levels. For example, other things can impact LDL-C such as M/PUFA-to-saturated fat composition, fiber, genetics, medication, etc.
FWIW, I think I've figured out the perfect experiment via weight loss alone.
If I were to lose, say, 10-15lbs but keep diet composition as identical as possible (thus no increase in sat fat), the LEM would predict increased LDL/ApoB independently
2/ This is a great design given there are now other food items that would change other than possibly a net reduction in overall calories to maintain at the lower weight (but if anything, that would mean less sat fat in the overall, ofc).
3/ Given how strikingly different each model would predict the outcome, it seems like a given I'm going to need to do this experiment.
There's even a chance I line it up before the fiber experiment. (Working out scheduling right now...)
1/ Listening to @theproof's podcast with @NutritionMadeS3 as I work. I'm really enjoying it thus far and I again commend Gil on his ability for distilling complex scientific discussion effectively in his YouTube videos.
2/ I just got through the part at 47:51 that had me stopping to write a couple thoughts... (the queued spot in the video linked hereπ)
@theproof brings up one's individual need to want to feel a "part of a community" (very big deal in the diet space)...
3/ ... And that "...it can challenge our identity if we come across information that is directly challenging one of these very strongly held views from within that community that our fellow community members also hold..."