Further evidence of persisting SARS-CoV-2 spike protein in #PASC #LongCovid patients, now if we can just #TreatLongCovid !
@harvardmed
medrxiv.org/content/10.110…
@harvardmed
medrxiv.org/content/10.110…
”In conclusion,
the presence of circulating spike in PASC patients up to 12 months post-diagnosis strongly suggests that SARS-CoV-2 viral reservoirs persist in the body…”
the presence of circulating spike in PASC patients up to 12 months post-diagnosis strongly suggests that SARS-CoV-2 viral reservoirs persist in the body…”
”Additionally,
the detection of spike in a majority of individuals included in our PASC cohort
provides strong support for the use of spike as a biomarker for PASC.”
the detection of spike in a majority of individuals included in our PASC cohort
provides strong support for the use of spike as a biomarker for PASC.”
”We were able to detect either S1, spike or N in approximately
65% of the patients diagnosed with PASC at any given time point, several months after infection. Most notably, we
detected circulating SARS-CoV-2 spike in the majority of PASC patients, but in none of the COVID-19”
65% of the patients diagnosed with PASC at any given time point, several months after infection. Most notably, we
detected circulating SARS-CoV-2 spike in the majority of PASC patients, but in none of the COVID-19”
”The presence of
circulating spike
supports the hypothesis that
a reservoir of active
virus persists in the body”
circulating spike
supports the hypothesis that
a reservoir of active
virus persists in the body”
”Persistent viral reservoirs are a
likely cause of PASC symptoms, but circulating spike may also give rise to
symptoms.”
likely cause of PASC symptoms, but circulating spike may also give rise to
symptoms.”
”Similar to bacterial superantigens, SARS-
CoV-2 spike protein
contains structural motifs that strongly interact with T cell receptors, creating
an imbalance in the T cell receptor repertoire.”
CoV-2 spike protein
contains structural motifs that strongly interact with T cell receptors, creating
an imbalance in the T cell receptor repertoire.”
”Unique to SARS-
CoV-2, it is thought
that the superantigen-
like motif may account for the hyperinflammatory response observed in severe COVID-19 and MIS-C patients.”
CoV-2, it is thought
that the superantigen-
like motif may account for the hyperinflammatory response observed in severe COVID-19 and MIS-C patients.”
”Although spike does not instigate a
cytokine storm in PASC…it could act through other mechanisms that interfere with normal cellular function…
spike alone was shown to disrupt signaling
pathways & induce dysfunction in pericytes, vascular endothelial cells, & the BBB”
cytokine storm in PASC…it could act through other mechanisms that interfere with normal cellular function…
spike alone was shown to disrupt signaling
pathways & induce dysfunction in pericytes, vascular endothelial cells, & the BBB”
”Alternatively,
PASC may manifest as cellular exhaustion or the induction of refractory inflammatory response but with persistent tissue localized dysfunction.”
PASC may manifest as cellular exhaustion or the induction of refractory inflammatory response but with persistent tissue localized dysfunction.”
”If PASC is the result of persistent viral replication in tissues outside the lung, it may
also explain why changes in circulating
inflammatory markers may be subtle when
measured in blood, although they may be elevated within a given tissue.”
also explain why changes in circulating
inflammatory markers may be subtle when
measured in blood, although they may be elevated within a given tissue.”
@surf4children @microbeminded2 @amibanerjee1 @PutrinoLab @DaveLeeERMD @VirusesImmunity @loscharlos @ChahindaGhoss @KunstJonas @dbkell @AMannanBaig @ShaneyWright @FreitasABR @TomasoAntonacci @elisaperego78 @resiapretorius @zalaly @MBVanElzakker @DonEford @ahandvanish @fearnley_k
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