Thread by @realDaveFeldman

1/ 🚨New N=1 Experiment: #IsItSaturatedFat🚨
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Yes, I'm doing a new N=1 -- and it's going to be a biggie!

My good friend and colleague, @DrNadolsky completed his recent #MakingLMHR experiment concluding the added 2 sticks of butter as the reason for his LDL increase.

2/ He's already conceded he's left out all the context on aiming for #LMHR profile, the relevance of RER, and the #LEM (so no need for people to keep pinging me on the IG video). I've chatted with him privately and we'll leave it at that. 👍

https://twitter.com/realDaveFeldman/status/1533182314640834560?s=20&t=rh5U-XklTUBGAR6o88hWVQ

3/ However -- this actually affords us a huge new opportunity.

@DrNadolsky's claim isn't just his own, it's just about everyone else's outside the low carb community.

Simply stated: high #LDL #cholesterol seen in #LMHRs is predominantly due to high consumption of saturated fat.

4/ Conversely, myself (and #LEM coauthors) posit it is more predominantly the Lipid Energy Model that explains higher #LDL in this context.*

This is why the RER readings were integral to the experiment when we first started talking about...

(*See mdpi.com/2218-1989/12/5…)

5/ Using these #LEM principles, I'd hypothesize I could consume the same proportion of calories from butter @DrNadolsky was, yet have a moderate to low LDL-C (keeping total calories at maintenance levels).

I'll have the write up for this experiment released soon, but for now...

6/ What do you think - can this really be demonstrated through dietary intervention alone using principles as detailed in the Lipid Energy Model?

Can I consume that much butter per day and demonstrate a moderate to even low #LDL #Cholesterol?