Thread by @firefoxx66

📡#Enterovirus #D68 #EVD68 builds on @nextstrain are now updated 📡

You can check out the VP1 (single-gene) build (nextstrain.org/enterovirus/d6…) & full-genome builds (nextstrain.org/enterovirus/d6…).

I'll give a brief overview of a few things of interest...

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https://twitter.com/firefoxx66/status/1565721872234340352

The VP1 #EVD68 build lets us include the most sequences, so I'll focus on that here - though full-genome has many other advantages!

No 2022 seqs yet (got my 👁️peeled!), but there are some from 2021 - from Europe & N America. These stem from the B3 & A2 clades.

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And more specifically, are related to seq clusters that circulated in 2018/2019.

Huge thanks to @HopkinsMedicine @AmaryFaln @NIBSC_MHRA Javier Martin, Alison Tedcastle @UKL_Leipzig Mario Hönemann @CHUDijon Alexis de Rougemont, Isabelle Schuffenecker & more for these seqs!

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Through @ENPEN_ESCV there will also be more sequences from across Europe from 2021 coming in - letting us get a good picture of pre-pandemic #Enterovirus #D68 #EVD68 & circulation last autumn in Europe.

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A lovely surprise was picking up #EVD68 sequences from #Australia in 2018/19. Particularly interesting as they mostly fall Feb-May 2019 - *after* the EU/N America autumn-winter outbreak pattern, & in Southern Hemisphere summer-autumn 🤔
They clearly link to EU/N America.

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This sparks interesting thoughts about the role of seasonality, schools/end-of-holidays, & international travel for #EVD68.
Another reason why equitable global data is so critical - otherwise, we are only seeing part of the picture! 🌏🌍🌎

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Huge thanks to @unsw @DrSachaSB @DrMarkFerson William Rawlinson et al. for these sequences - read their whole paper here (& double-thanks for providing ages & symptoms, which I've incorporated! 🙏🏻)
sciencedirect.com/science/articl…

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