In #biotech #stocks news, no opening to the US market today due to Labor Day holiday, which is a perfect time to discuss the only stock in the list of #biotech companies that I track, which is not listed in the US stock market: $ONT.L Oxford @nanopore
ONT decided to IPO in the UK rather than the NASDAQ, with two main consequences to the stock price: (1) many of the retail broker apps with a US Dollar account won't trade it as easily as US stocks, and (2) the value of the stock will correlate with the value of GBP vs USD.
The later can be seen when looking at $ONT.L Oxford @nanopore stock versus the GBPUSD trend line (yellow): when the GBP loses value to the US Dollar, seemingly ONT loses value, being traded in GBP. And vice versa, for a large pharma company such as $AZN Astrazeneca ...
... which is also headquartered in the UK but brings in most of their revenue in US Dollars, when the USD gains value over GBP, Astrazeneca UK share price seemingly increases in value (orange line). But we can also see the Astrazeneca ADR ticker in purple, which in the last ...
... 12 months has gone down in an offset of about 10% compared to the UK ticker (orange). The difference can be explained by the one year change in value of GBP over USD, and partly also by the relative interest in US broker account on the stock over ex-US (UK accounts).
This is thus a way to compare two companies with markedly different levels of revenues that they bring in as either US Dollars or other denominations, and how they correlate or anti-correlate with the relative value of the GB Pound compared to the US Dollar.
So when evaluating any non-US traded companies, we need to do a bit more work other than bringing up their trend line on Google or Yahoo Finance, and instead take into account the currency of the revenues and the stock where they trade.
$ONT.L Oxford @nanopore is expected to describe year revenues in September 2022, which compared to companies that give lots of details on a quarterly basis, means it'll be one of the most important inflection points for the trade value. Compared to the other #longreads company...
... out there, $PACB @PacBio which trades in the NASDAQ, we can see how the later in purple has had more markedly drops in the last year, particularly the Q4 2021 revenues drop which brought it down from -30% to -60% in a matter of days.
So, as a summary, all the companies in the #biotech #stocks list that I follow are down in the last 12-18 month window, but some more than others, and the tempo of the drops and increases in value is affected by the timings of their earnings reports and currency fluctuations.

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More from @AlbertVilella

Sep 6
Chris Seymour at $ONT.L Oxford @nanopore tweets about Apple Silicon's AMX instruction set. A mysterious set of instructions now beginning to be mapped out by a group of volunteer developers. So what does Apple Silicon mean for #Bioinformatics?
As many will know, $AAPL Apple came up with their own silicon a few years ago, a branch off the @Arm 64-bit designs, of which they've been diverging ever since. The Apple M1 and M2 cores have been thoroughly reviewed in social media, but less from the optics of #Bioinformatics. Image
First of all, what reason did @Apple have to design their own silicon? Could they not just have adopted an @Arm design and stick to it? Well, the history of the company is full of examples of Apple wanting to do "their own thing" rather than integrating someone else's silicon... Image
Read 10 tweets
Aug 25
Another twitter profile of one of the #biotech #stocks that I track, this time it's $TWST TwistBio. The company is a DNA Write company, currently applying their tech to #SynthBio, #NGS and #AntibodyDiscovery Image
The different segments are easy to explain, and in many cases we can draw analogies to $ILMN Illumina in #NGS: they provide products and services to different segments as a 'tools' provider. Now on to Twist Biopharma, here is were things get complicated.
Twist Biopharma is by all intends an purposes just another branch that concentrates on the antibody side of things. Part of what they offer is just more 'products and services', like they would do with NGS or SynthBio. The complicated part is their intention to also engage...
Read 8 tweets
Aug 25
In #biotech #stocks, another market opening, another tough readjustement of expectations for $NVTA Invitae at -7% opening.
The 5-day chart shows a seesawing pattern, with peaks coming from the 1-2 initial hours of market, which quickly deflate either within the day's trade value or the next day. As mentioned before in this twitter account, the shape of these can sometimes be indicative of a large...
... institutional fund loading up, submitting orders at a certain tick for a certain period of time, and adjusting the rate of buys to the response from the rest of the market. $NVTA Invitae's top institutional holders are well spread, with @ARKInvest on top at 12.5%
Read 5 tweets
Aug 25
The field of #NGS is heating up and new contenders are now shipping their new instruments out there. MGI Tech is heading to both the US and the main European markets, whereas Element Bio, Singular and Ultima Genomics are starting in the US first, aiming at outside US the in 2023.
There are other companies with new tech out there that want to use to displace $ILMN Illumina's market share, including $PACB PacBio which is giving an update on their new tech in October, and $ONT.L Oxford @nanopore that has been shipping Kit14 for the last couple of months now.
$ILMN Illumina themselves are pencilled for their Chemistry X update, but for the noises they've made so far, it seems this will be a platform update, meaning the now 1000s of NovaSeqs and NextSeqs out there will need to be replaced. Think multi-year wave of stock update.
Read 5 tweets
Aug 24
In #biotech #stocks news, $TXG @10xGenomics is opening upwards +4% in today's trading. The company is down more than 75% in the 52-wk window. They peaked in Q1 2021 and have since then declined at a similar pace as other $XBI stocks out there.
$TXG is in the #Singlecell and #Spatial biology field. They've recently made their pivot into Spatial Biology apparent, and have both an #NGS Next-Generation Sequencing and #InSitu imaging play on it, with their #Visium and #Xenium lines respectively.
The $TXG top institutional holders include Morgan Stanley with less than 10%, followed by 3 of the heavy hitters in #biotech: UK's Baillie Gifford, Vanguard Group, and Black Rock.
Read 5 tweets
Aug 24
An article describing the "45 is the new 50" change in guidelines in the US for #ColorectalCancer #Screening. Slightly biased towards $EXAS Exact Sciences Cologuard. ache.org/blog/2022/upda…
$EXAS Exact Sciences is one of the companies I track, in many ways a pioneer in the #LiquidBiopsy #CancerScreening field although with a low-tech method compared to other players in this field such as $ILMN Illumina (via @GrailBio), and what other companies are planning ...
Read 6 tweets

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